CRCGN017_MCF10A.WT.HP_24H:A23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ammonium-perfluorocaprylate 32.99 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

180 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:A23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 10.0
AGR2 anterior gradient 2 5.86375
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.24302
NANOS3 nanos homolog 3 (Drosophila) 5.0
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.5902
SQOR sulfide quinone oxidoreductase 4.5761
CNRIP1 cannabinoid receptor interacting protein 1 3.9873
WASF3 WAS protein family, member 3 3.8098
STMN2 stathmin 2 3.65887
CHEK1 checkpoint kinase 1 3.62103
STAP2 signal transducing adaptor family member 2 3.46945
NSG2 neuronal vesicle trafficking associated 2 3.34435
TAC1 tachykinin, precursor 1 3.32465
SYN1 synapsin I 3.22705
SNAP91 synaptosomal-associated protein, 91kDa 3.19405
SLC75A1 solute carrier family 75 member 1 3.1655
SYT1 synaptotagmin I 3.13625
MRFAP1L1 Morf4 family associated protein 1-like 1 3.00235
MAMLD1 mastermind-like domain containing 1 2.9055
GUF1 GUF1 GTPase homolog (S. cerevisiae) 2.82795
TSPAN6 tetraspanin 6 2.80623
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.75745
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.7288
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.6513
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.59355
RGS7 regulator of G-protein signaling 7 2.5934
RNF4 ring finger protein 4 2.5444
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.52405
NOP14 NOP14 nucleolar protein 2.50555
DCTN4 dynactin 4 (p62) 2.49415
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.48975
RCOR3 REST corepressor 3 2.46585
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.45465
METTL18 methyltransferase like 18 2.4422
SMYD3 SET and MYND domain containing 3 2.42045
TEFM transcription elongation factor, mitochondrial 2.4155
LGI1 leucine-rich, glioma inactivated 1 2.39345
VSNL1 visinin-like 1 2.39185
SNX19 sorting nexin 19 2.37675
MGST3 microsomal glutathione S-transferase 3 2.3659
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.3547
OBI1 ORC ubiquitin ligase 1 2.3479
SDHAF3 succinate dehydrogenase complex assembly factor 3 2.3434
NAV3 neuron navigator 3 2.3417
MTMR6 myotubularin related protein 6 2.3068
THAP1 THAP domain containing, apoptosis associated protein 1 2.29635
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.29445
GRAMD1B GRAM domain containing 1B 2.29145
APLNR apelin receptor 2.28865
IGFBP4 insulin-like growth factor binding protein 4 2.28795
ZBTB38 zinc finger and BTB domain containing 38 2.28655
TSC22D4 TSC22 domain family, member 4 2.28105
ADD1 adducin 1 (alpha) 2.24563
PPCS phosphopantothenoylcysteine synthetase 2.238
PUS3 pseudouridylate synthase 3 2.23745
NEK4 NIMA-related kinase 4 2.2363
SCG3 secretogranin III 2.2354
APLP2 amyloid beta (A4) precursor-like protein 2 2.23372
TMEM185B transmembrane protein 185B 2.2161
IRX5 iroquois homeobox 5 2.2016
TRPM4 transient receptor potential cation channel, subfamily M, member 4 2.1912
TMEM267 transmembrane protein 267 2.1907
SV2B synaptic vesicle glycoprotein 2B 2.18485
MAEA macrophage erythroblast attacher 2.18475
BATF3 basic leucine zipper transcription factor, ATF-like 3 2.1836
BEX2 brain expressed X-linked 2 2.1832
COQ8A coenzyme Q8A 2.1572
FADD Fas (TNFRSF6)-associated via death domain 2.1564
ADGRB3 adhesion G protein-coupled receptor B3 2.15375
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 2.15142
ZNF586 zinc finger protein 586 2.14515
RUNDC3B RUN domain containing 3B 2.14235
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 2.14128
FKTN fukutin 2.1399
SLC26A2 solute carrier family 26 (anion exchanger), member 2 2.1295
ZNF510 zinc finger protein 510 2.1253
FBXL4 F-box and leucine-rich repeat protein 4 2.11665
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.11525
ZNF189 zinc finger protein 189 2.11105
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1 2.1106
KDM2A lysine (K)-specific demethylase 2A 2.09785
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.0972
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.0938
MCRS1 microspherule protein 1 2.0934
CALCB calcitonin-related polypeptide beta 2.08225
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.0804
PALS1 protein associated with LIN7 1, MAGUK p55 family member 2.0798
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.07865
CH25H cholesterol 25-hydroxylase 2.076
ZNF443 zinc finger protein 443 2.0709
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 2.05975
CEP15 centrosomal protein 15 2.05955
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 2.05825
FBXL5 F-box and leucine-rich repeat protein 5 2.04428
SAMM50 SAMM50 sorting and assembly machinery component 2.04165
SPA17 sperm autoantigenic protein 17 2.0217
REPS2 RALBP1 associated Eps domain containing 2 2.019
KANSL1 KAT8 regulatory NSL complex subunit 1 2.01705
TBC1D12 TBC1 domain family, member 12 2.01685
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 2.0163
STARD13 StAR-related lipid transfer (START) domain containing 13 2.0088

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.538
KRT14 keratin 14, type I -5.0
S100A8 S100 calcium binding protein A8 -5.0
SGK1 serum/glucocorticoid regulated kinase 1 -4.86915
PCNA proliferating cell nuclear antigen -4.81085
YME1L1 YME1-like 1 ATPase -4.78055
CCNB2 cyclin B2 -4.7206
FKBP4 FK506 binding protein 4, 59kDa -3.5819
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) -3.52115
DDRGK1 DDRGK domain containing 1 -3.2162
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.1775
XPO7 exportin 7 -3.10238
TENT4A terminal nucleotidyltransferase 4A -3.0305
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -2.86985
CD79B CD79b molecule, immunoglobulin-associated beta -2.77985
EFNA4 ephrin-A4 -2.73555
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 -2.6909
ACAA1 acetyl-CoA acyltransferase 1 -2.66715
CD53 CD53 molecule -2.66405
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -2.59536
PANK2 pantothenate kinase 2 -2.5421
DCN decorin -2.51076
ADGRG6 adhesion G protein-coupled receptor G6 -2.48135
FCN3 ficolin (collagen/fibrinogen domain containing) 3 -2.47865
STAP1 signal transducing adaptor family member 1 -2.47825
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.4312
LOC102724428 serine/threonine-protein kinase SIK1 -2.41395
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.40467
WASHC4 WASH complex subunit 4 -2.36848
LYZ lysozyme -2.34795
ZNF91 zinc finger protein 91 -2.3403
PPIB peptidylprolyl isomerase B (cyclophilin B) -2.31865
TMEM45A transmembrane protein 45A -2.31465
OSBPL10 oxysterol binding protein-like 10 -2.2644
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.2507
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.22883
AKR1C4 aldo-keto reductase family 1, member C4 -2.2254
TMEM230 transmembrane protein 230 -2.2241
GDF5 growth differentiation factor 5 -2.188
MAVS mitochondrial antiviral signaling protein -2.1852
NSFL1C NSFL1 (p97) cofactor (p47) -2.17618
ZNF750 zinc finger protein 750 -2.1746
RNF111 ring finger protein 111 -2.17235
BDKRB1 bradykinin receptor B1 -2.17115
HBG1 hemoglobin, gamma A -2.1682
PRRX1 paired related homeobox 1 -2.1643
ACAN aggrecan -2.15617
TLCD3A TLC domain containing 3A -2.1532
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -2.1307
MOXD1 monooxygenase, DBH-like 1 -2.1302
CXCL9 chemokine (C-X-C motif) ligand 9 -2.12875
SH2D4A SH2 domain containing 4A -2.1131
GBP2 guanylate binding protein 2, interferon-inducible -2.11275
ALOX5 arachidonate 5-lipoxygenase -2.10215
GCH1 GTP cyclohydrolase 1 -2.10015
PRRX2 paired related homeobox 2 -2.0898
MARCO macrophage receptor with collagenous structure -2.0882
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -2.0855
MACO1 macoilin 1 -2.07985
WFDC1 WAP four-disulfide core domain 1 -2.074
TMEM140 transmembrane protein 140 -2.0728
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 -2.0715
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 -2.06885
GJA8 gap junction protein, alpha 8, 50kDa -2.06775
ADM adrenomedullin -2.05765
RHAG Rh-associated glycoprotein -2.0564
ABI1 abl-interactor 1 -2.05282
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) -2.03505
ALDOB aldolase B, fructose-bisphosphate -2.02898
SDC1 syndecan 1 -2.02875
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2 -2.02812
HGD homogentisate 1,2-dioxygenase -2.02168
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 -2.0189
EPHX2 epoxide hydrolase 2, cytoplasmic -2.01695
G6PC1 glucose-6-phosphatase catalytic subunit 1 -2.0136
VPREB3 pre-B lymphocyte 3 -2.00915
CSPG4 chondroitin sulfate proteoglycan 4 -2.00795
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 -2.00403
BLNK B-cell linker -2.00105