CRCGN017_MCF10A.WT.HP_24H:B03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:B03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.83512
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.86411
PKN1 protein kinase N1 3.09526
RSF1 remodeling and spacing factor 1 2.94694
ACAA1 acetyl-CoA acyltransferase 1 2.87334
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.71691
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.65328
CCL2 chemokine (C-C motif) ligand 2 2.48043
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.33122
PEX11A peroxisomal biogenesis factor 11 alpha 2.32618
RCAN3 RCAN family member 3 2.16563
HBB hemoglobin, beta 2.13168
TFCP2 transcription factor CP2 2.07127
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 2.04591
KLHL9 kelch-like family member 9 2.0103
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 2.00496

decreased expression

Symbol Name Standardized Value
CD58 CD58 molecule -3.34471
EIF5 eukaryotic translation initiation factor 5 -3.04225
CCNB1 cyclin B1 -2.98402
HEATR1 HEAT repeat containing 1 -2.79197
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.68505
MSMO1 methylsterol monooxygenase 1 -2.64586
WASHC4 WASH complex subunit 4 -2.62279
SCYL3 SCY1-like 3 (S. cerevisiae) -2.57236
MT2A metallothionein 2A -2.49446
MOXD1 monooxygenase, DBH-like 1 -2.26946
CD82 CD82 molecule -2.15559
CD81 CD81 molecule -2.13317
DSG2 desmoglein 2 -2.09919
MT1X metallothionein 1X -2.04252
PFN1 profilin 1 -2.04049