CRCGN017_MCF10A.WT.HP_24H:B07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5,7-dichloro-4-(4-fluorophenoxy)quinoline 102.9 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

60 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:B07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 5.3681
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 4.91265
TBP TATA box binding protein 4.8647
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 4.77358
KIF5C kinesin family member 5C 4.23403
NUCB2 nucleobindin 2 3.80795
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.8289
TCEA2 transcription elongation factor A (SII), 2 2.55305
GLRX glutaredoxin (thioltransferase) 2.5232
HMOX1 heme oxygenase 1 2.52155
CDC7 cell division cycle 7 2.4622
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 2.38755
DZIP3 DAZ interacting zinc finger protein 3 2.19718
REV1 REV1, polymerase (DNA directed) 2.19365
ZNF514 zinc finger protein 514 2.1468
CXCL3 chemokine (C-X-C motif) ligand 3 2.14155
HOXA5 homeobox A5 2.0912
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 2.08825
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 2.07485
SEC24B SEC24 family member B 2.0626
DUSP2 dual specificity phosphatase 2 2.0382
UCMA upper zone of growth plate and cartilage matrix associated 2.0344
COQ8A coenzyme Q8A 2.01495

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -5.01835
CD81 CD81 molecule -4.498
ADRB2 adrenoceptor beta 2, surface -4.3129
PMM2 phosphomannomutase 2 -3.93765
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.87715
GADD45B growth arrest and DNA-damage-inducible, beta -3.2916
LTA4H leukotriene A4 hydrolase -2.61005
CASZ1 castor zinc finger 1 -2.6093
PFN1 profilin 1 -2.53205
RBM34 RNA binding motif protein 34 -2.53042
HOXC11 homeobox C11 -2.5055
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.3583
C1QBP complement component 1, q subcomponent binding protein -2.3474
HOXC10 homeobox C10 -2.33605
AGER advanced glycosylation end product-specific receptor -2.30713
MSMO1 methylsterol monooxygenase 1 -2.30115
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.2926
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase -2.2864
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.2768
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) -2.27265
XAB2 XPA binding protein 2 -2.2148
CLIC3 chloride intracellular channel 3 -2.1742
ULBP2 UL16 binding protein 2 -2.17025
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 -2.1597
NBEAL2 neurobeachin-like 2 -2.1379
NOSIP nitric oxide synthase interacting protein -2.1214
EMP2 epithelial membrane protein 2 -2.11575
ALDOC aldolase C, fructose-bisphosphate -2.09015
GPRC5A G protein-coupled receptor, class C, group 5, member A -2.0788
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.06585
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.04888
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.04685
RPS5 ribosomal protein S5 -2.0413
TLE5 TLE family member 5, transcriptional modulator -2.039
CLDN4 claudin 4 -2.02835
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough -2.0257
METRN meteorin, glial cell differentiation regulator -2.00585