CRCGN017_MCF10A.WT.HP_24H:B08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5,7-dichloro-4-(4-fluorophenoxy)quinoline 34.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:B08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.76358
SPAG4 sperm associated antigen 4 4.50705
SQOR sulfide quinone oxidoreductase 4.23255
AXIN1 axin 1 3.53335
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 3.26255
TENT4A terminal nucleotidyltransferase 4A 2.76325
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.17085
TRAPPC4 trafficking protein particle complex 4 2.10608
MMP2 matrix metallopeptidase 2 2.06075

decreased expression

Symbol Name Standardized Value
SLC25A46 solute carrier family 25, member 46 -5.3757
MSMO1 methylsterol monooxygenase 1 -4.58075
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.4632
VAT1 vesicle amine transport 1 -4.34565
PPIC peptidylprolyl isomerase C (cyclophilin C) -4.06833
SGK1 serum/glucocorticoid regulated kinase 1 -3.35695
CD81 CD81 molecule -3.32355
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.00649
MSN moesin -2.90765
S100A8 S100 calcium binding protein A8 -2.90165
RALGDS ral guanine nucleotide dissociation stimulator -2.84407
COPS7A COP9 signalosome subunit 7A -2.779
ADRB2 adrenoceptor beta 2, surface -2.72775
RPS5 ribosomal protein S5 -2.38565
RPS8 ribosomal protein S8 -2.2699
MVD mevalonate (diphospho) decarboxylase -2.26745
NOP53 NOP53 ribosome biogenesis factor -2.215
MAPK3 mitogen-activated protein kinase 3 -2.1412
PFN1 profilin 1 -2.0366
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.0363