CRCGN017_MCF10A.WT.HP_24H:B09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5,7-dichloro-4-(4-fluorophenoxy)quinoline 11.43 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

42 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:B09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCR4 chemokine (C-X-C motif) receptor 4 5.11332
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.1113
STK10 serine/threonine kinase 10 4.72835
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 4.51523
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.7503
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.93105
PDLIM1 PDZ and LIM domain 1 2.92935
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.78535
HOXA5 homeobox A5 2.4434
HDAC3 histone deacetylase 3 2.1999
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.1665
MBIP MAP3K12 binding inhibitory protein 1 2.0711

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -5.46485
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.0324
DNM1L dynamin 1-like -5.00995
YME1L1 YME1-like 1 ATPase -4.86605
SNCA synuclein, alpha (non A4 component of amyloid precursor) -4.04694
BID BH3 interacting domain death agonist -3.9262
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -3.84975
TKT transketolase -3.44375
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.1833
NLRP4 NLR family, pyrin domain containing 4 -3.07325
MTPAP mitochondrial poly(A) polymerase -2.78285
WASHC4 WASH complex subunit 4 -2.58535
IGFBP7 insulin-like growth factor binding protein 7 -2.55715
ABI1 abl-interactor 1 -2.48495
CYB561 cytochrome b561 -2.39858
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) -2.35515
TMPRSS2 transmembrane protease, serine 2 -2.32778
XPO7 exportin 7 -2.32008
RASAL2 RAS protein activator like 2 -2.17225
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.1583
FOS FBJ murine osteosarcoma viral oncogene homolog -2.14225
FAM110D family with sequence similarity 110, member D -2.12685
CD81 CD81 molecule -2.09335
WAC WW domain containing adaptor with coiled-coil -2.05958
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1 -2.05325
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) -2.04445
EFS embryonal Fyn-associated substrate -2.04327
PHOX2B paired-like homeobox 2b -2.0359
S100A8 S100 calcium binding protein A8 -2.01675
TEAD3 TEA domain family member 3 -2.0081