CRCGN017_MCF10A.WT.HP_24H:B12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-ethyl-n-nitrosourea 11.96 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

18 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:B12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.66275
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.64345
ACAA1 acetyl-CoA acyltransferase 1 3.34315
WIF1 WNT inhibitory factor 1 2.8944
OLFML2B olfactomedin-like 2B 2.72825
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.53295
BTK Bruton agammaglobulinemia tyrosine kinase 2.30685
HBA1 hemoglobin, alpha 1 2.06192
CBX1 chromobox homolog 1 2.0186

decreased expression

Symbol Name Standardized Value
GOLT1B golgi transport 1B -5.05675
UBE3C ubiquitin protein ligase E3C -4.33585
KRT14 keratin 14, type I -4.3157
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.79855
WASHC4 WASH complex subunit 4 -2.70165
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.55263
WDR7 WD repeat domain 7 -2.31755
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.17833
GDF15 growth differentiation factor 15 -2.10305