CRCGN017_MCF10A.WT.HP_24H:B13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description indole 100.0 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:B13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 5.42835
SPAG4 sperm associated antigen 4 5.24195
STAP2 signal transducing adaptor family member 2 5.2067
CCP110 centriolar coiled coil protein 110kDa 4.80965
CCL2 chemokine (C-C motif) ligand 2 3.5649
WIF1 WNT inhibitory factor 1 3.27075
TBX2 T-box 2 3.1241
ACAA1 acetyl-CoA acyltransferase 1 3.08002
TIMP2 TIMP metallopeptidase inhibitor 2 2.9566
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.2301
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 2.16705
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.1372
OLFML2B olfactomedin-like 2B 2.1041
FZD6 frizzled class receptor 6 2.08915
TFRC transferrin receptor 2.04725

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.22165
PCCB propionyl CoA carboxylase, beta polypeptide -5.04025
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.6661
CCDC86 coiled-coil domain containing 86 -4.4865
GDF15 growth differentiation factor 15 -3.9783
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.70303
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.6958
NT5DC2 5'-nucleotidase domain containing 2 -3.5546
HEATR1 HEAT repeat containing 1 -2.99565
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.92855
CREB1 cAMP responsive element binding protein 1 -2.81184
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -2.796
RPS5 ribosomal protein S5 -2.67705
AGO1 argonaute RISC catalytic component 1 -2.5548
CETN2 centrin, EF-hand protein, 2 -2.38925
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -2.2628
TFF1 trefoil factor 1 -2.1828
GNL1 guanine nucleotide binding protein-like 1 -2.14995
TKFC triokinase/FMN cyclase -2.1087
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 -2.0799
DENND4C DENN/MADD domain containing 4C -2.00695
BCL6 B-cell CLL/lymphoma 6 -2.00688