CRCGN017_MCF10A.WT.HP_24H:B16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description flutamide 100.0 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

211 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:B16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIAM1 T-cell lymphoma invasion and metastasis 1 5.42882
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.7915
CCL2 chemokine (C-C motif) ligand 2 4.0362
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 3.9408
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 3.6595
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.60545
SNCA synuclein, alpha (non A4 component of amyloid precursor) 3.46141
WIF1 WNT inhibitory factor 1 3.3237
PCM1 pericentriolar material 1 3.31047
FURIN furin (paired basic amino acid cleaving enzyme) 3.243
STX1A syntaxin 1A (brain) 3.1313
NRBF2 nuclear receptor binding factor 2 3.10875
CADM1 cell adhesion molecule 1 3.07645
SH2B3 SH2B adaptor protein 3 2.97265
MSRA methionine sulfoxide reductase A 2.9348
HMGA2 high mobility group AT-hook 2 2.91435
EPHA2 EPH receptor A2 2.8871
CDCP1 CUB domain containing protein 1 2.857
GLRX glutaredoxin (thioltransferase) 2.82785
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.81345
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 2.7879
GPATCH8 G patch domain containing 8 2.73525
RABGAP1L RAB GTPase activating protein 1-like 2.7207
AGR2 anterior gradient 2 2.7096
PYCR1 pyrroline-5-carboxylate reductase 1 2.68955
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2.67868
SPRY2 sprouty homolog 2 (Drosophila) 2.6681
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.65045
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.6138
EGR3 early growth response 3 2.5715
PLXNB2 plexin B2 2.5656
NPAS2 neuronal PAS domain protein 2 2.56342
DUSP4 dual specificity phosphatase 4 2.56005
KIF13B kinesin family member 13B 2.55585
FYN FYN proto-oncogene, Src family tyrosine kinase 2.46983
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 2.4677
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 2.46418
MN1 meningioma (disrupted in balanced translocation) 1 2.459
CEP57 centrosomal protein 57kDa 2.44138
CBR4 carbonyl reductase 4 2.43595
ADA2 adenosine deaminase 2 2.4202
RHOBTB2 Rho-related BTB domain containing 2 2.41275
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 2.39787
GID4 GID complex subunit 4 2.38485
INTS3 integrator complex subunit 3 2.382
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.3746
FGD1 FYVE, RhoGEF and PH domain containing 1 2.36945
PHF20L1 PHD finger protein 20-like 1 2.36465
TENT4A terminal nucleotidyltransferase 4A 2.3466
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 2.34517
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.34258
ITGB5 integrin, beta 5 2.33703
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 2.32285
LYN LYN proto-oncogene, Src family tyrosine kinase 2.24767
CHIC2 cysteine-rich hydrophobic domain 2 2.24575
ETV5 ets variant 5 2.23855
VPREB1 pre-B lymphocyte 1 2.2204
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 2.2174
GAS2 growth arrest-specific 2 2.2094
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 2.20423
ISOC1 isochorismatase domain containing 1 2.202
ECM1 extracellular matrix protein 1 2.2006
ZNF451 zinc finger protein 451 2.18938
AKIP1 A kinase (PRKA) interacting protein 1 2.18545
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 2.1843
TRIB3 tribbles pseudokinase 3 2.16405
SLC35F2 solute carrier family 35, member F2 2.1638
CAV3 caveolin 3 2.1618
LUZP1 leucine zipper protein 1 2.1593
RNF44 ring finger protein 44 2.1525
JRKL JRK-like 2.14815
DROSHA drosha, ribonuclease type III 2.13315
NAV2 neuron navigator 2 2.1213
CST2 cystatin SA 2.1177
KIAA0930 KIAA0930 2.11555
DUSP6 dual specificity phosphatase 6 2.1146
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 2.1127
MTMR11 myotubularin related protein 11 2.1053
MORC2 MORC family CW-type zinc finger 2 2.09837
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.0865
IL20RA interleukin 20 receptor, alpha 2.08375
LRRC37A3 leucine rich repeat containing 37, member A3 2.07405
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 2.06647
GDF10 growth differentiation factor 10 2.05285
SH3GLB1 SH3-domain GRB2-like endophilin B1 2.05198
PTPRE protein tyrosine phosphatase, receptor type, E 2.04515
SLCO4A1 solute carrier organic anion transporter family, member 4A1 2.04395
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.03223
LIF leukemia inhibitory factor 2.02815
KLHL7 kelch-like family member 7 2.02352
TRIB1 tribbles pseudokinase 1 2.0174
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.01255
DKK3 dickkopf WNT signaling pathway inhibitor 3 2.01163

decreased expression

Symbol Name Standardized Value
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -6.0332
NUP85 nucleoporin 85kDa -5.58225
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.3653
PUF60 poly-U binding splicing factor 60KDa -5.2673
PPIC peptidylprolyl isomerase C (cyclophilin C) -4.55535
UBE3C ubiquitin protein ligase E3C -4.5511
CANT1 calcium activated nucleotidase 1 -4.53215
MRPS7 mitochondrial ribosomal protein S7 -4.23165
ARID4B AT rich interactive domain 4B (RBP1-like) -4.10645
CREG1 cellular repressor of E1A-stimulated genes 1 -4.08345
LLGL2 lethal giant larvae homolog 2 (Drosophila) -3.82735
RNASE7 ribonuclease, RNase A family, 7 -3.82115
MRPL58 mitochondrial ribosomal protein L58 -3.6495
ADI1 acireductone dioxygenase 1 -3.44875
SH3D19 SH3 domain containing 19 -3.41765
ATF5 activating transcription factor 5 -3.38277
GRB2 growth factor receptor-bound protein 2 -3.3532
S100A8 S100 calcium binding protein A8 -3.34615
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -3.23785
POLDIP2 polymerase (DNA-directed), delta interacting protein 2 -3.15725
NRIP1 nuclear receptor interacting protein 1 -3.15635
DRC9 dynein regulatory complex subunit 9 -3.03405
ADRB2 adrenoceptor beta 2, surface -3.00835
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.9787
SLC25A46 solute carrier family 25, member 46 -2.9304
KCTD2 potassium channel tetramerization domain containing 2 -2.9184
SAP30BP SAP30 binding protein -2.90405
ZDHHC6 zinc finger, DHHC-type containing 6 -2.8383
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.8375
RALGDS ral guanine nucleotide dissociation stimulator -2.76503
ARMC7 armadillo repeat containing 7 -2.7499
POMT1 protein-O-mannosyltransferase 1 -2.73925
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) -2.71235
EIF4A3 eukaryotic translation initiation factor 4A3 -2.65105
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.6477
MSMO1 methylsterol monooxygenase 1 -2.5716
CENPX centromere protein X -2.5432
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.51555
SPOP speckle-type POZ protein -2.50653
NINJ1 ninjurin 1 -2.48755
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.4834
TDG thymine-DNA glycosylase -2.47905
PRCP prolylcarboxypeptidase (angiotensinase C) -2.47155
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 -2.47015
NFIL3 nuclear factor, interleukin 3 regulated -2.4437
GADD45G growth arrest and DNA-damage-inducible, gamma -2.4418
SRSF2 serine/arginine-rich splicing factor 2 -2.44157
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.43405
SIAH2 siah E3 ubiquitin protein ligase 2 -2.43015
FASN fatty acid synthase -2.42916
BAD BCL2-associated agonist of cell death -2.427
NT5C 5', 3'-nucleotidase, cytosolic -2.4072
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -2.40433
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.40163
TMEM94 transmembrane protein 94 -2.38575
TENT5C terminal nucleotidyltransferase 5C -2.3845
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) -2.3718
MVD mevalonate (diphospho) decarboxylase -2.36685
MRPL49 mitochondrial ribosomal protein L49 -2.3605
SYNGR2 synaptogyrin 2 -2.3565
NT5DC2 5'-nucleotidase domain containing 2 -2.3527
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -2.35155
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.3501
TEX10 testis expressed 10 -2.3488
TMEM50A transmembrane protein 50A -2.342
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.3406
RBM4B RNA binding motif protein 4B -2.33965
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.33935
DOLK dolichol kinase -2.29775
JPT1 Jupiter microtubule associated homolog 1 -2.27885
FDXR ferredoxin reductase -2.27665
MRPL11 mitochondrial ribosomal protein L11 -2.27425
ATP5PD ATP synthase peripheral stalk subunit d -2.27375
BPHL biphenyl hydrolase-like (serine hydrolase) -2.27255
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.2662
ARPC4-TTLL3 ARPC4-TTLL3 readthrough -2.24853
WBP1L WW domain binding protein 1-like -2.2398
MCRS1 microspherule protein 1 -2.23955
DOLPP1 dolichyldiphosphatase 1 -2.23795
MSRB1 methionine sulfoxide reductase B1 -2.23365
GLOD4 glyoxalase domain containing 4 -2.2311
SUMO4 small ubiquitin-like modifier 4 -2.20155
TPGS1 tubulin polyglutamylase complex subunit 1 -2.19435
PRR15L proline rich 15-like -2.1924
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.18565
CYBC1 cytochrome b-245 chaperone 1 -2.17825
ZNF747 zinc finger protein 747 -2.17125
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -2.16545
TLCD3A TLC domain containing 3A -2.16545
TXNL1 thioredoxin-like 1 -2.15785
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.14965
CDC42 cell division cycle 42 -2.14904
DENND5B DENN/MADD domain containing 5B -2.1362
TMEM168 transmembrane protein 168 -2.13125
SOAT2 sterol O-acyltransferase 2 -2.1242
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor -2.11888
NGRN neugrin, neurite outgrowth associated -2.11685
SCARB1 scavenger receptor class B, member 1 -2.11637
AKTIP AKT interacting protein -2.0969
CIRBP cold inducible RNA binding protein -2.09425
RTF2 replication termination factor 2 -2.09265
PEPD peptidase D -2.08585
RAB1B RAB1B, member RAS oncogene family -2.07995
EYA2 EYA transcriptional coactivator and phosphatase 2 -2.07215
SFXN1 sideroflexin 1 -2.07185
UBAC1 UBA domain containing 1 -2.0667
UNG uracil-DNA glycosylase -2.0651
FAM50B family with sequence similarity 50, member B -2.0505
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.04735
STX17 syntaxin 17 -2.03735
ZSCAN5A zinc finger and SCAN domain containing 5A -2.0335
SPOUT1 SPOUT domain containing methyltransferase 1 -2.0272
HOXC6 homeobox C6 -2.02715
HACD2 3-hydroxyacyl-CoA dehydratase 2 -2.02215
BAG1 BCL2-associated athanogene -2.01727
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -2.00985
CTSG cathepsin G -2.00545
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 -2.00495