CRCGN017_MCF10A.WT.HP_24H:B18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description flutamide 11.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:B18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.81333
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.6242
FCHO1 FCH domain only 1 3.55855
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 3.3006
GPATCH8 G patch domain containing 8 3.2301
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 3.1522
ALG8 ALG8, alpha-1,3-glucosyltransferase 3.14565
AURKB aurora kinase B 3.13965
MMP2 matrix metallopeptidase 2 2.8795
RBBP5 retinoblastoma binding protein 5 2.8686
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.8658
WIF1 WNT inhibitory factor 1 2.8435
RSF1 remodeling and spacing factor 1 2.77555
SNX7 sorting nexin 7 2.76095
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.7321
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 2.60578
SH2D4A SH2 domain containing 4A 2.46555
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 2.39717
MDM4 MDM4, p53 regulator 2.38505
NOD1 nucleotide-binding oligomerization domain containing 1 2.3696
KAT6B K(lysine) acetyltransferase 6B 2.34243
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.30395
AAMDC adipogenesis associated, Mth938 domain containing 2.29743
PKN1 protein kinase N1 2.2528
SP140L SP140 nuclear body protein-like 2.22855
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.2283
STRN3 striatin, calmodulin binding protein 3 2.22345
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 2.2211
FSTL1 follistatin-like 1 2.14905
ADA2 adenosine deaminase 2 2.13215
MTA2 metastasis associated 1 family, member 2 2.0783
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.0721
KDM3B lysine (K)-specific demethylase 3B 2.05413
CSNK1A1 casein kinase 1, alpha 1 2.05069
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.0256

decreased expression

Symbol Name Standardized Value
ARID4B AT rich interactive domain 4B (RBP1-like) -5.43615
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.9782
PCCB propionyl CoA carboxylase, beta polypeptide -4.6895
NGRN neugrin, neurite outgrowth associated -4.0932
HSPD1 heat shock 60kDa protein 1 (chaperonin) -3.80527
COPS7A COP9 signalosome subunit 7A -3.4671
ACAA1 acetyl-CoA acyltransferase 1 -3.00192
ATF5 activating transcription factor 5 -2.76262
BPHL biphenyl hydrolase-like (serine hydrolase) -2.69975
TM2D3 TM2 domain containing 3 -2.6567
FAM171A1 family with sequence similarity 171, member A1 -2.40525
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.37103
BASP1 brain abundant, membrane attached signal protein 1 -2.34055
KLHDC4 kelch domain containing 4 -2.33685
CCDC92 coiled-coil domain containing 92 -2.313
PSIP1 PC4 and SFRS1 interacting protein 1 -2.15233
CBR3 carbonyl reductase 3 -2.1445
IFT88 intraflagellar transport 88 -2.14295
HOXC10 homeobox C10 -2.0968
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 -2.0825
TUFM Tu translation elongation factor, mitochondrial -2.0551
ADAM15 ADAM metallopeptidase domain 15 -2.04055