CRCGN017_MCF10A.WT.HP_24H:B19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-nitropyrene 99.1 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:B19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GET1 guided entry of tail-anchored proteins factor 1 4.45405
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.92895
KIF5C kinesin family member 5C 3.79822
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.7593
SESN1 sestrin 1 3.01305
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.6718
NES nestin 2.6145
CDPF1 cysteine-rich, DPF motif domain containing 1 2.52695
FAM193A family with sequence similarity 193, member A 2.19315
SNX7 sorting nexin 7 2.17945
ZMIZ1 zinc finger, MIZ-type containing 1 2.10315
PELI1 pellino E3 ubiquitin protein ligase 1 2.07725
RTN1 reticulon 1 2.06575
ISOC1 isochorismatase domain containing 1 2.05715
AHNAK2 AHNAK nucleoprotein 2 2.0098

decreased expression

Symbol Name Standardized Value
ETFB electron-transfer-flavoprotein, beta polypeptide -4.96005
TSPAN4 tetraspanin 4 -4.88065
PCNA proliferating cell nuclear antigen -4.66275
MT2A metallothionein 2A -4.523
STXBP2 syntaxin binding protein 2 -4.3473
MBOAT7 membrane bound O-acyltransferase domain containing 7 -3.82535
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.71327
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.52745
COPS7A COP9 signalosome subunit 7A -3.10615
TSEN34 TSEN34 tRNA splicing endonuclease subunit -3.10395
MT1X metallothionein 1X -3.0018
ACAA1 acetyl-CoA acyltransferase 1 -2.88975
DDRGK1 DDRGK domain containing 1 -2.78695
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.6625
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.66155
PANK2 pantothenate kinase 2 -2.37955
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 -2.28685
BASP1 brain abundant, membrane attached signal protein 1 -2.25895
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.22775
PRDX1 peroxiredoxin 1 -2.2148
UBE2C ubiquitin-conjugating enzyme E2C -2.1917
FKBP1C FK506 binding protein 1C -2.179
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.17375
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.17085
LPCAT3 lysophosphatidylcholine acyltransferase 3 -2.16385
PRCP prolylcarboxypeptidase (angiotensinase C) -2.06625
RPS5 ribosomal protein S5 -2.04385
RALY RALY heterogeneous nuclear ribonucleoprotein -2.0249
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 -2.00002