CRCGN017_MCF10A.WT.HP_24H:B20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-nitropyrene 33.03 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

114 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:B20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WFS1 Wolfram syndrome 1 (wolframin) 5.5517
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.5446
LAGE3 L antigen family, member 3 5.45705
STK10 serine/threonine kinase 10 5.15365
C2CD2 C2 calcium-dependent domain containing 2 4.88745
AMDHD2 amidohydrolase domain containing 2 4.77155
KIF5C kinesin family member 5C 3.88905
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.86637
NOTCH1 notch 1 3.45065
AMZ2 archaelysin family metallopeptidase 2 3.147
SIRT3 sirtuin 3 2.91652
SESN1 sestrin 1 2.80325
CDPF1 cysteine-rich, DPF motif domain containing 1 2.70825
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 2.51185
BIRC7 baculoviral IAP repeat containing 7 2.50085
SIN3B SIN3 transcription regulator family member B 2.49215
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.4849
ERI2 ERI1 exoribonuclease family member 2 2.45985
SAP130 Sin3A-associated protein, 130kDa 2.4289
BOLA1 bolA family member 1 2.4047
THUMPD1 THUMP domain containing 1 2.31207
PTPRE protein tyrosine phosphatase, receptor type, E 2.30675
QTRT2 queuine tRNA-ribosyltransferase accessory subunit 2 2.28975
ZNF787 zinc finger protein 787 2.2799
AGR2 anterior gradient 2 2.2572
NME3 NME/NM23 nucleoside diphosphate kinase 3 2.25675
TMEM186 transmembrane protein 186 2.2289
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 2.22725
SUCO SUN domain containing ossification factor 2.1808
TIGAR TP53 induced glycolysis regulatory phosphatase 2.17275
TRIM37 tripartite motif containing 37 2.1673
GUCY2C guanylate cyclase 2C 2.1598
CARD8 caspase recruitment domain family, member 8 2.15185
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.12125
PRX periaxin 2.1182
CARMIL1 capping protein regulator and myosin 1 linker 1 2.1154
RBM22 RNA binding motif protein 22 2.1101
GSTT1 glutathione S-transferase theta 1 2.08245
MAEA macrophage erythroblast attacher 2.04355
APTX aprataxin 2.0298
L1TD1 LINE-1 type transposase domain containing 1 2.0274
OXCT2 3-oxoacid CoA transferase 2 2.01935
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.0172
CSNK1A1 casein kinase 1, alpha 1 2.01535
RYR1 ryanodine receptor 1 (skeletal) 2.00765
FAM110A family with sequence similarity 110, member A 2.0012

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -5.0
PRPF4 pre-mRNA processing factor 4 -4.97382
TKT transketolase -4.77252
MT2A metallothionein 2A -4.24055
MSMO1 methylsterol monooxygenase 1 -3.52275
BASP1 brain abundant, membrane attached signal protein 1 -3.45785
HIPK3 homeodomain interacting protein kinase 3 -3.34383
KCTD20 potassium channel tetramerization domain containing 20 -3.25285
AFF4 AF4/FMR2 family, member 4 -3.17125
LYPLA1 lysophospholipase I -3.07973
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit -3.07745
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -3.06895
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -3.0183
SCYL2 SCY1-like 2 (S. cerevisiae) -2.9834
NKRF NFKB repressing factor -2.84745
ACAA1 acetyl-CoA acyltransferase 1 -2.83248
LMAN1 lectin, mannose-binding, 1 -2.82608
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.79405
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -2.70305
FPGS folylpolyglutamate synthase -2.6902
BSPRY B-box and SPRY domain containing -2.6508
SLC25A40 solute carrier family 25, member 40 -2.6357
PTBP3 polypyrimidine tract binding protein 3 -2.63317
TMOD3 tropomodulin 3 (ubiquitous) -2.6156
GFUS GDP-L-fucose synthase -2.61042
EML4 echinoderm microtubule associated protein like 4 -2.57615
OSMR oncostatin M receptor -2.4864
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.4762
DAND5 DAN domain family member 5, BMP antagonist -2.43135
ATL2 atlastin GTPase 2 -2.4093
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.39795
PRKCD protein kinase C, delta -2.39785
SKAP2 src kinase associated phosphoprotein 2 -2.38877
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -2.3827
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.37755
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.35905
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -2.3459
IGFBP7 insulin-like growth factor binding protein 7 -2.3317
NMD3 NMD3 ribosome export adaptor -2.3087
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.2993
HOXA5 homeobox A5 -2.29815
RAB23 RAB23, member RAS oncogene family -2.29335
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -2.2832
DKK1 dickkopf WNT signaling pathway inhibitor 1 -2.27855
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.2749
MT1X metallothionein 1X -2.2634
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.26058
POLR1F RNA polymerase I subunit F -2.25195
CXCL8 chemokine (C-X-C motif) ligand 8 -2.24425
YAF2 YY1 associated factor 2 -2.24135
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -2.2245
TMED3 transmembrane emp24 protein transport domain containing 3 -2.2159
CDK6 cyclin-dependent kinase 6 -2.21165
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -2.14645
OXA1L oxidase (cytochrome c) assembly 1-like -2.14135
CALR calreticulin -2.1291
BAG4 BCL2-associated athanogene 4 -2.09935
UPK1B uroplakin 1B -2.07382
MTUS1 microtubule associated tumor suppressor 1 -2.07002
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -2.0675
TAGLN2 transgelin 2 -2.05837
NIPAL2 NIPA-like domain containing 2 -2.0569
RLIM ring finger protein, LIM domain interacting -2.05155
BCAT1 branched chain amino-acid transaminase 1, cytosolic -2.04948
TGFBR1 transforming growth factor, beta receptor 1 -2.04835
MEGF9 multiple EGF-like-domains 9 -2.04128
CUL4B cullin 4B -2.03965
FRS2 fibroblast growth factor receptor substrate 2 -2.0017