CRCGN017_MCF10A.WT.HP_24H:C02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-diindolylmethane 33.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

359 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:C02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.42205
GLRX glutaredoxin (thioltransferase) 3.87182
SSBP2 single-stranded DNA binding protein 2 3.79269
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.62097
ABHD6 abhydrolase domain containing 6 3.51981
MAMLD1 mastermind-like domain containing 1 3.40116
GARRE1 granule associated Rac and RHOG effector 1 3.3668
CHIC2 cysteine-rich hydrophobic domain 2 3.26738
RAI14 retinoic acid induced 14 3.14636
PPOX protoporphyrinogen oxidase 3.14021
ADGRG1 adhesion G protein-coupled receptor G1 3.07404
RAP1GAP RAP1 GTPase activating protein 3.03558
CRELD2 cysteine-rich with EGF-like domains 2 2.99148
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.80067
MSRA methionine sulfoxide reductase A 2.76249
KLHDC2 kelch domain containing 2 2.70313
WASHC5 WASH complex subunit 5 2.6972
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.6889
COL11A1 collagen, type XI, alpha 1 2.66875
TRIB3 tribbles pseudokinase 3 2.6414
IL4R interleukin 4 receptor 2.63854
RIPPLY3 ripply transcriptional repressor 3 2.63679
SNAP29 synaptosomal-associated protein, 29kDa 2.5938
ETAA1 Ewing tumor-associated antigen 1 2.57288
STX4 syntaxin 4 2.57263
NIT1 nitrilase 1 2.56283
SMIM40 small integral membrane protein 40 2.55534
IL1B interleukin 1, beta 2.54926
TIMP2 TIMP metallopeptidase inhibitor 2 2.52276
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.51873
MGAT4C MGAT4 family, member C 2.50096
PRND prion protein 2 (dublet) 2.49442
ACAA1 acetyl-CoA acyltransferase 1 2.49053
CERK ceramide kinase 2.48457
ZNF492 zinc finger protein 492 2.47038
ZNF493 zinc finger protein 493 2.46603
ARL15 ADP-ribosylation factor-like 15 2.45795
TESK1 testis-specific kinase 1 2.45602
SALL2 spalt-like transcription factor 2 2.45139
MTM1 myotubularin 1 2.44654
MMP2 matrix metallopeptidase 2 2.43039
CNTN5 contactin 5 2.42253
ZNF74 zinc finger protein 74 2.42126
ASGR1 asialoglycoprotein receptor 1 2.42039
PCDHB8 protocadherin beta 8 2.40537
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 2.40022
MYEF2 myelin expression factor 2 2.39748
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.38305
ZBTB3 zinc finger and BTB domain containing 3 2.37042
ZNF682 zinc finger protein 682 2.36327
PPIAL4H peptidylprolyl isomerase A like 4H 2.35756
RGCC regulator of cell cycle 2.34989
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 2.34144
MSTN myostatin 2.33541
GP5 glycoprotein V (platelet) 2.33447
UGDH UDP-glucose 6-dehydrogenase 2.33422
AFAP1 actin filament associated protein 1 2.33373
HMGA2 high mobility group AT-hook 2 2.32833
NKX3-2 NK3 homeobox 2 2.32328
TMEM19 transmembrane protein 19 2.31246
WDR19 WD repeat domain 19 2.31006
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.30782
E2F5 E2F transcription factor 5, p130-binding 2.30562
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit 2.29957
SORCS3 sortilin-related VPS10 domain containing receptor 3 2.29841
SPRED2 sprouty-related, EVH1 domain containing 2 2.29544
SNX13 sorting nexin 13 2.28578
TRMT9B tRNA methyltransferase 9B (putative) 2.28339
RAG2 recombination activating gene 2 2.27676
ZNF214 zinc finger protein 214 2.27086
USH2A Usher syndrome 2A (autosomal recessive, mild) 2.26703
CEP97 centrosomal protein 97kDa 2.26575
TMOD2 tropomodulin 2 (neuronal) 2.26398
FCHO1 FCH domain only 1 2.26376
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.25725
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.25418
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.25097
LY96 lymphocyte antigen 96 2.25065
SSX1 synovial sarcoma, X breakpoint 1 2.2505
TEX12 testis expressed 12 2.24506
IKZF3 IKAROS family zinc finger 3 (Aiolos) 2.24046
FEZF2 FEZ family zinc finger 2 2.24001
TRIM49B tripartite motif containing 49B 2.23477
GPRASP1 G protein-coupled receptor associated sorting protein 1 2.23311
PPEF2 protein phosphatase, EF-hand calcium binding domain 2 2.23142
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.22596
OR2W1 olfactory receptor, family 2, subfamily W, member 1 2.2255
ZNF132 zinc finger protein 132 2.22421
MYL9 myosin, light chain 9, regulatory 2.21669
SCN9A sodium channel, voltage gated, type IX alpha subunit 2.2118
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.21049
RAVER2 ribonucleoprotein, PTB-binding 2 2.21002
ANGPTL8 angiopoietin like 8 2.20995
ARMCX2 armadillo repeat containing, X-linked 2 2.20139
TAS2R8 taste receptor, type 2, member 8 2.20038
ZNF780B zinc finger protein 780B 2.19986
SEMG2 semenogelin II 2.1976
ELOVL4 ELOVL fatty acid elongase 4 2.19512
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.19125
FAM114A1 family with sequence similarity 114, member A1 2.19073
NGRN neugrin, neurite outgrowth associated 2.19066
ZIC3 Zic family member 3 2.18778
RAB31 RAB31, member RAS oncogene family 2.18754
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 2.18664
SOX3 SRY (sex determining region Y)-box 3 2.1839
GEMIN8 gem (nuclear organelle) associated protein 8 2.18379
LINC02854 long intergenic non-protein coding RNA 2854 2.17804
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 2.1768
SLC25A30 solute carrier family 25, member 30 2.17664
OR2B2 olfactory receptor, family 2, subfamily B, member 2 2.17537
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 2.17461
ZNF280D zinc finger protein 280D 2.17355
INHBE inhibin, beta E 2.17331
RHD Rh blood group, D antigen 2.17306
PBOV1 prostate and breast cancer overexpressed 1 2.1729
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.17185
TERT telomerase reverse transcriptase 2.1709
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 2.16725
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide 2.16561
RGS18 regulator of G-protein signaling 18 2.16515
CHN1 chimerin 1 2.15916
DOK5 docking protein 5 2.15719
H1-5 H1.5 linker histone, cluster member 2.15682
GPR22 G protein-coupled receptor 22 2.15681
PURG purine-rich element binding protein G 2.15665
GRB7 growth factor receptor-bound protein 7 2.15649
F2RL2 coagulation factor II (thrombin) receptor-like 2 2.15318
IFNA8 interferon, alpha 8 2.15227
TRPC5 transient receptor potential cation channel, subfamily C, member 5 2.15015
ZNF157 zinc finger protein 157 2.1499
TIGD6 tigger transposable element derived 6 2.14886
FAM13C family with sequence similarity 13, member C 2.14619
FRMPD4 FERM and PDZ domain containing 4 2.14175
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 2.141
GRIK4 glutamate receptor, ionotropic, kainate 4 2.14033
CCDC121 coiled-coil domain containing 121 2.14028
CIAO3 cytosolic iron-sulfur assembly component 3 2.1396
PDE12 phosphodiesterase 12 2.13933
GAGE1 G antigen 1 2.13839
GSDMB gasdermin B 2.13465
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.13453
PTPRB protein tyrosine phosphatase, receptor type, B 2.13363
BICDL1 BICD family like cargo adaptor 1 2.13336
CCDC144A coiled-coil domain containing 144A 2.13107
ZNF674 zinc finger protein 674 2.1297
KRTAP9-9 keratin associated protein 9-9 2.12908
RAB21 RAB21, member RAS oncogene family 2.12762
BCO1 beta-carotene oxygenase 1 2.12675
TRPC3 transient receptor potential cation channel, subfamily C, member 3 2.12665
GPR63 G protein-coupled receptor 63 2.12578
UNC5C unc-5 homolog C (C. elegans) 2.1254
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.12398
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.12388
SCARF1 scavenger receptor class F, member 1 2.12372
RFX4 regulatory factor X, 4 (influences HLA class II expression) 2.12361
RTN1 reticulon 1 2.1231
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.12081
KERA keratocan 2.11068
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2.10741
IFNA16 interferon, alpha 16 2.10704
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 2.10494
DGKE diacylglycerol kinase, epsilon 64kDa 2.10099
NMBR neuromedin B receptor 2.09985
GOLGA6B golgin A6 family, member B 2.09827
GTPBP10 GTP-binding protein 10 (putative) 2.09558
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 2.09526
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 2.09483
VASH1 vasohibin 1 2.09399
CA5B carbonic anhydrase VB, mitochondrial 2.09136
ADGRE3 adhesion G protein-coupled receptor E3 2.09126
GLRA3 glycine receptor, alpha 3 2.09011
SUSD5 sushi domain containing 5 2.08959
TMSB15B thymosin beta 15B 2.08928
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.0889
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.087
KLF8 Kruppel-like factor 8 2.08633
RADX RPA1 related single stranded DNA binding protein, X-linked 2.08577
H2BC17 H2B clustered histone 17 2.08489
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.08454
KRT12 keratin 12, type I 2.08293
JHY junctional cadherin complex regulator 2.08113
PKD2L2 polycystic kidney disease 2-like 2 2.08081
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2.08046
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 2.07871
FRMPD1 FERM and PDZ domain containing 1 2.0786
KMT2D lysine (K)-specific methyltransferase 2D 2.07721
TAS2R10 taste receptor, type 2, member 10 2.07516
IFNAR1 interferon (alpha, beta and omega) receptor 1 2.07456
CNKSR2 connector enhancer of kinase suppressor of Ras 2 2.07436
LPA lipoprotein, Lp(a) 2.07405
ZNF141 zinc finger protein 141 2.07375
MAGEB3 melanoma antigen family B3 2.07339
ZNF80 zinc finger protein 80 2.07331
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 2.0726
PEDS1 plasmanylethanolamine desaturase 1 2.07194
TAS2R13 taste receptor, type 2, member 13 2.07168
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 2.07147
YIPF4 Yip1 domain family, member 4 2.07111
ATP2A3 ATPase, Ca++ transporting, ubiquitous 2.07105
TPST2 tyrosylprotein sulfotransferase 2 2.0701
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.06709
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 2.06425
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.06323
EMILIN2 elastin microfibril interfacer 2 2.06307
MTMR7 myotubularin related protein 7 2.06229
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.06107
TDP2 tyrosyl-DNA phosphodiesterase 2 2.05992
MAGEA8 melanoma antigen family A8 2.0592
POU6F2 POU class 6 homeobox 2 2.05861
ZNF711 zinc finger protein 711 2.05829
GPR50 G protein-coupled receptor 50 2.05827
CTAGE1 cutaneous T-cell lymphoma-associated antigen 1 2.05755
DOCK4 dedicator of cytokinesis 4 2.05733
PF4V1 platelet factor 4 variant 1 2.05301
CFAP43 cilia and flagella associated protein 43 2.05255
ZNF701 zinc finger protein 701 2.05192
ZNF232 zinc finger protein 232 2.05088
TLL1 tolloid-like 1 2.0507
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.04981
CCR9 chemokine (C-C motif) receptor 9 2.04915
PCDHGA8 protocadherin gamma subfamily A, 8 2.04884
KDM4D lysine (K)-specific demethylase 4D 2.04786
GJD3 gap junction protein, delta 3, 31.9kDa 2.04773
PLGLB2 plasminogen-like B2 2.04745
SEMG1 semenogelin I 2.04628
FAM135A family with sequence similarity 135, member A 2.04424
KNL1 kinetochore scaffold 1 2.0428
RPE65 retinal pigment epithelium-specific protein 65kDa 2.04195
TKFC triokinase/FMN cyclase 2.04053
FAM204A family with sequence similarity 204, member A 2.03861
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 2.03783
IL18R1 interleukin 18 receptor 1 2.03756
ZNF81 zinc finger protein 81 2.03747
RING1 ring finger protein 1 2.0359
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 2.03491
PTTG2 pituitary tumor-transforming 2 2.03432
IMPG1 interphotoreceptor matrix proteoglycan 1 2.03417
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 2.03132
ZNF154 zinc finger protein 154 2.03038
TSHR thyroid stimulating hormone receptor 2.02827
PCDH8 protocadherin 8 2.02588
CLEC5A C-type lectin domain family 5, member A 2.0252
TRIM49D2 tripartite motif containing 49D2 2.02505
ZNF549 zinc finger protein 549 2.02375
ARID5B AT rich interactive domain 5B (MRF1-like) 2.02372
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.02245
R3HCC1L R3H domain and coiled-coil containing 1-like 2.0224
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 2.02226
CDK14 cyclin-dependent kinase 14 2.02153
OR11A1 olfactory receptor, family 11, subfamily A, member 1 2.02083
THAP9 THAP domain containing 9 2.01915
PBX1 pre-B-cell leukemia homeobox 1 2.019
FSHR follicle stimulating hormone receptor 2.0185
ANO2 anoctamin 2, calcium activated chloride channel 2.01827
PPARA peroxisome proliferator-activated receptor alpha 2.01641
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 2.0161
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 2.01593
ZNF407 zinc finger protein 407 2.01493
IFNA5 interferon, alpha 5 2.01493
DGKI diacylglycerol kinase, iota 2.01492
ARID3A AT rich interactive domain 3A (BRIGHT-like) 2.01458
ATAD5 ATPase family, AAA domain containing 5 2.01373
CNMD chondromodulin 2.01367
USP27X ubiquitin specific peptidase 27, X-linked 2.01351
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 2.01343
NPHP1 nephronophthisis 1 (juvenile) 2.01167
PPIB peptidylprolyl isomerase B (cyclophilin B) 2.01144
SIGLEC6 sialic acid binding Ig-like lectin 6 2.01097
GAL3ST4 galactose-3-O-sulfotransferase 4 2.01088
LOC102724560 cystathionine beta-synthase 2.01071
RAD21L1 RAD21-like 1 (S. pombe) 2.00991
ZNF440 zinc finger protein 440 2.00921
GREM1 gremlin 1, DAN family BMP antagonist 2.00883
PRDM13 PR domain containing 13 2.00818
INSL5 insulin-like 5 2.0077
OR12D3 olfactory receptor, family 12, subfamily D, member 3 2.00621
NEUROD1 neuronal differentiation 1 2.00336
CYP3A7-CYP3A51P CYP3A7-CYP3A51P readthrough 2.00331
MMP27 matrix metallopeptidase 27 2.00307
NUP62CL nucleoporin 62kDa C-terminal like 2.00129

decreased expression

Symbol Name Standardized Value
CD81 CD81 molecule -5.87338
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.79927
PUF60 poly-U binding splicing factor 60KDa -4.24876
ADRB2 adrenoceptor beta 2, surface -4.06166
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -3.87251
RGS2 regulator of G-protein signaling 2 -3.74036
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.38917
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -3.27875
SORBS3 sorbin and SH3 domain containing 3 -3.25246
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D -3.21862
MT2A metallothionein 2A -3.19895
SLC25A46 solute carrier family 25, member 46 -3.16662
TUBB6 tubulin, beta 6 class V -3.16456
MAPK13 mitogen-activated protein kinase 13 -3.11202
CDC20 cell division cycle 20 -3.10316
BLCAP bladder cancer associated protein -3.07482
STMN1 stathmin 1 -3.07203
HOXA5 homeobox A5 -3.04425
CASC3 cancer susceptibility candidate 3 -2.88543
TEX10 testis expressed 10 -2.84202
FASTKD5 FAST kinase domains 5 -2.80945
SNX6 sorting nexin 6 -2.80346
WASHC4 WASH complex subunit 4 -2.75854
KIF20A kinesin family member 20A -2.74754
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.72515
AURKA aurora kinase A -2.64544
TATDN2 TatD DNase domain containing 2 -2.54178
RNF220 ring finger protein 220 -2.53748
CD320 CD320 molecule -2.52222
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -2.49688
TP53 tumor protein p53 -2.4469
PARL presenilin associated, rhomboid-like -2.44672
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -2.42858
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.34967
RALGDS ral guanine nucleotide dissociation stimulator -2.3338
GLOD4 glyoxalase domain containing 4 -2.32293
EXOSC4 exosome component 4 -2.3194
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.3087
ARHGAP10 Rho GTPase activating protein 10 -2.3082
PRKCD protein kinase C, delta -2.29846
SETD3 SET domain containing 3 -2.29261
PRMT1 protein arginine methyltransferase 1 -2.28833
PARP1 poly (ADP-ribose) polymerase 1 -2.28591
USP19 ubiquitin specific peptidase 19 -2.26647
TSPAN4 tetraspanin 4 -2.26146
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.25334
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -2.23034
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.22919
GYS1 glycogen synthase 1 (muscle) -2.22896
LDHD lactate dehydrogenase D -2.22859
PCCB propionyl CoA carboxylase, beta polypeptide -2.2038
LOC112694756 uncharaterized LOC112694756 -2.19989
BAG3 BCL2-associated athanogene 3 -2.18875
HACD2 3-hydroxyacyl-CoA dehydratase 2 -2.18762
LBR lamin B receptor -2.17711
PDLIM2 PDZ and LIM domain 2 (mystique) -2.17653
NEK7 NIMA-related kinase 7 -2.1632
S100A11 S100 calcium binding protein A11 -2.15986
AKAP11 A kinase (PRKA) anchor protein 11 -2.1586
MICU2 mitochondrial calcium uptake 2 -2.1527
GSTP1 glutathione S-transferase pi 1 -2.15167
SLIRP SRA stem-loop interacting RNA binding protein -2.14924
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -2.1465
UQCRC1 ubiquinol-cytochrome c reductase core protein I -2.14515
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.13281
EBNA1BP2 EBNA1 binding protein 2 -2.12522
TRIM28 tripartite motif containing 28 -2.12357
TOP2A topoisomerase (DNA) II alpha 170kDa -2.10669
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 -2.10164
BACE2 beta-site APP-cleaving enzyme 2 -2.09669
UQCRH ubiquinol-cytochrome c reductase hinge protein -2.09324
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -2.09195
RNASE7 ribonuclease, RNase A family, 7 -2.08007
UFM1 ubiquitin-fold modifier 1 -2.07667
MTPAP mitochondrial poly(A) polymerase -2.05707
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.02619
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -2.01173
ZDHHC6 zinc finger, DHHC-type containing 6 -2.00872
SRSF9 serine/arginine-rich splicing factor 9 -2.00477