CRCGN017_MCF10A.WT.HP_24H:C03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-diindolylmethane 11.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:C03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 5.04448
ACAA1 acetyl-CoA acyltransferase 1 4.89284
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.85947
E2F2 E2F transcription factor 2 3.7424
HBA1 hemoglobin, alpha 1 3.63438
GPER1 G protein-coupled estrogen receptor 1 3.58175
PPARG peroxisome proliferator-activated receptor gamma 3.39131
ANO1 anoctamin 1, calcium activated chloride channel 3.07177
CD40 CD40 molecule, TNF receptor superfamily member 5 2.49731
HBB hemoglobin, beta 2.47861
MOK MOK protein kinase 2.44035
CHN1 chimerin 1 2.43125
SNAP25 synaptosomal-associated protein, 25kDa 2.30547
STAP2 signal transducing adaptor family member 2 2.08992
MSRA methionine sulfoxide reductase A 2.0508
NGRN neugrin, neurite outgrowth associated 2.04589
LOC102724652 alpha-crystallin A chain 2.02597

decreased expression

Symbol Name Standardized Value
HOXA5 homeobox A5 -5.13031
CD81 CD81 molecule -4.49451
TUBB6 tubulin, beta 6 class V -4.39311
TXNDC9 thioredoxin domain containing 9 -3.98701
UBE3C ubiquitin protein ligase E3C -3.45863
RALGDS ral guanine nucleotide dissociation stimulator -3.11134
CANT1 calcium activated nucleotidase 1 -3.03199
NRIP1 nuclear receptor interacting protein 1 -2.67505
THAP11 THAP domain containing 11 -2.27891
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.19565
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.19094
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.16246
ANXA2 annexin A2 -2.15157
CAMLG calcium modulating ligand -2.11859
COPS7A COP9 signalosome subunit 7A -2.03793