CRCGN017_MCF10A.WT.HP_24H:C04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description leflunomide 100.0 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

153 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:C04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STX1A syntaxin 1A (brain) 5.33851
EGR1 early growth response 1 4.71725
HMGA2 high mobility group AT-hook 2 4.69316
DHRS2 dehydrogenase/reductase (SDR family) member 2 4.39685
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 4.31706
WIF1 WNT inhibitory factor 1 4.21653
PPARG peroxisome proliferator-activated receptor gamma 4.18183
FKBP14 FK506 binding protein 14, 22 kDa 4.11916
ANO1 anoctamin 1, calcium activated chloride channel 4.01504
ACAA1 acetyl-CoA acyltransferase 1 3.97764
SNAP25 synaptosomal-associated protein, 25kDa 3.73114
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.47171
FOSL1 FOS-like antigen 1 3.33168
EGR3 early growth response 3 3.12864
NT5E 5'-nucleotidase, ecto (CD73) 2.90142
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.90098
PNKP polynucleotide kinase 3'-phosphatase 2.89235
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.84866
CHIC2 cysteine-rich hydrophobic domain 2 2.80312
FHL2 four and a half LIM domains 2 2.79017
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2.7486
DUSP6 dual specificity phosphatase 6 2.73737
BCL10 B-cell CLL/lymphoma 10 2.72205
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.70799
TRIB1 tribbles pseudokinase 1 2.65951
CEP170 centrosomal protein 170kDa 2.65397
INPP1 inositol polyphosphate-1-phosphatase 2.64863
EAPP E2F-associated phosphoprotein 2.64392
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.59215
STEAP1B STEAP family member 1B 2.52687
PHC2 polyhomeotic homolog 2 (Drosophila) 2.5211
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 2.5112
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 2.50122
LIF leukemia inhibitory factor 2.49336
NRIP1 nuclear receptor interacting protein 1 2.47928
HJURP Holliday junction recognition protein 2.47171
FZD7 frizzled class receptor 7 2.45928
PLS1 plastin 1 2.44359
IL1B interleukin 1, beta 2.43726
FOS FBJ murine osteosarcoma viral oncogene homolog 2.43056
CAB39 calcium binding protein 39 2.42422
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 2.41664
IER3 immediate early response 3 2.39728
SPRY2 sprouty homolog 2 (Drosophila) 2.39363
KIF14 kinesin family member 14 2.35631
LAMC2 laminin, gamma 2 2.3435
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.33662
ZFP36 ZFP36 ring finger protein 2.32714
RAI14 retinoic acid induced 14 2.28025
BCAR3 breast cancer anti-estrogen resistance 3 2.27796
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.27226
ITPRID2 ITPR interacting domain containing 2 2.21107
OSMR oncostatin M receptor 2.19291
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.17201
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 2.15139
CDCP1 CUB domain containing protein 1 2.14281
TFB1M transcription factor B1, mitochondrial 2.14023
TRIOBP TRIO and F-actin binding protein 2.12576
LAMB1 laminin, beta 1 2.10764
EPHA2 EPH receptor A2 2.08877
CEMIP2 cell migration inducing hyaluronidase 2 2.06059
GLRX glutaredoxin (thioltransferase) 2.05927
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.05802
SMAD3 SMAD family member 3 2.05034
SDC4 syndecan 4 2.03529
SPRY4 sprouty homolog 4 (Drosophila) 2.01714
SOWAHC sosondowah ankyrin repeat domain family member C 2.00344

decreased expression

Symbol Name Standardized Value
CD81 CD81 molecule -4.25296
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -3.8496
SKIC8 SKI8 subunit of superkiller complex -3.6224
PRR15L proline rich 15-like -3.44141
CDPF1 cysteine-rich, DPF motif domain containing 1 -3.35364
CREG1 cellular repressor of E1A-stimulated genes 1 -3.20845
ATF5 activating transcription factor 5 -3.04268
FAIM Fas apoptotic inhibitory molecule -2.99094
MSMO1 methylsterol monooxygenase 1 -2.97801
TUBA4A tubulin, alpha 4a -2.95247
SOAT2 sterol O-acyltransferase 2 -2.94711
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.90244
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.86814
PFN1 profilin 1 -2.85779
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.80047
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.79502
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.7804
GADD45B growth arrest and DNA-damage-inducible, beta -2.77122
PCCB propionyl CoA carboxylase, beta polypeptide -2.72922
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.69097
HSPB2 heat shock 27kDa protein 2 -2.61433
AMDHD2 amidohydrolase domain containing 2 -2.55796
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.55727
NUSAP1 nucleolar and spindle associated protein 1 -2.5538
BAD BCL2-associated agonist of cell death -2.49817
CIRBP cold inducible RNA binding protein -2.48552
HSPB1 heat shock 27kDa protein 1 -2.45253
BCL2L10 BCL2-like 10 (apoptosis facilitator) -2.43457
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.42007
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) -2.41665
PARD6A par-6 family cell polarity regulator alpha -2.4117
MATN4 matrilin 4 -2.40258
NOTCH1 notch 1 -2.38637
RAB1B RAB1B, member RAS oncogene family -2.37413
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 -2.37092
EVX1 even-skipped homeobox 1 -2.35652
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) -2.34949
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 -2.33992
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.33833
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 -2.32608
FUT2 fucosyltransferase 2 (secretor status included) -2.30901
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein -2.30578
SGK1 serum/glucocorticoid regulated kinase 1 -2.2835
NME5 NME/NM23 family member 5 -2.27679
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -2.27639
CLBA1 clathrin binding box of aftiphilin containing 1 -2.26377
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.26085
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.25891
TMEM9B TMEM9 domain family, member B -2.25355
RALGDS ral guanine nucleotide dissociation stimulator -2.25319
TSC22D3 TSC22 domain family, member 3 -2.23532
FABP3 fatty acid binding protein 3, muscle and heart -2.22008
PRCP prolylcarboxypeptidase (angiotensinase C) -2.20638
SCARB1 scavenger receptor class B, member 1 -2.20512
NFIL3 nuclear factor, interleukin 3 regulated -2.19527
MVK mevalonate kinase -2.1836
DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 -2.18283
ZDHHC6 zinc finger, DHHC-type containing 6 -2.17566
LGALS7B lectin, galactoside-binding, soluble, 7B -2.16281
MYNN myoneurin -2.15214
GADD45G growth arrest and DNA-damage-inducible, gamma -2.15213
FADS2 fatty acid desaturase 2 -2.15194
CRYBB1 crystallin, beta B1 -2.14772
ADGRB1 adhesion G protein-coupled receptor B1 -2.12644
CGRRF1 cell growth regulator with ring finger domain 1 -2.11596
TMCO1 transmembrane and coiled-coil domains 1 -2.11062
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) -2.09246
TUBA4B tubulin, alpha 4b -2.08828
MVP major vault protein -2.08393
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 -2.08334
BIRC7 baculoviral IAP repeat containing 7 -2.08178
TCEA2 transcription elongation factor A (SII), 2 -2.07874
ZNF268 zinc finger protein 268 -2.07265
WASHC4 WASH complex subunit 4 -2.062
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like -2.05496
ATRIP ATR interacting protein -2.05239
TMEM109 transmembrane protein 109 -2.0459
WNT4 wingless-type MMTV integration site family, member 4 -2.03519
CYB5R1 cytochrome b5 reductase 1 -2.03176
ZNF787 zinc finger protein 787 -2.02545
BLVRB biliverdin reductase B -2.02199
CERS4 ceramide synthase 4 -2.0202
WDR45B WD repeat domain 45B -2.01728
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 -2.01468
ZNF35 zinc finger protein 35 -2.00304
MVD mevalonate (diphospho) decarboxylase -2.00195