CRCGN017_MCF10A.WT.HP_24H:C05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description leflunomide 33.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:C05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.00233
ANO1 anoctamin 1, calcium activated chloride channel 3.8385
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.65997
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.37951
KLHL21 kelch-like family member 21 3.30439
WIF1 WNT inhibitory factor 1 3.07767
GPER1 G protein-coupled estrogen receptor 1 2.94709
HMGA2 high mobility group AT-hook 2 2.82972
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.71805
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.54536
MYLK myosin light chain kinase 2.41944
ECD ecdysoneless homolog (Drosophila) 2.32652
SSBP2 single-stranded DNA binding protein 2 2.28464
EREG epiregulin 2.27613
MSRA methionine sulfoxide reductase A 2.25896
SUMF2 sulfatase modifying factor 2 2.23212
SNAP25 synaptosomal-associated protein, 25kDa 2.14774
SPRY2 sprouty homolog 2 (Drosophila) 2.14335
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.13245
REV1 REV1, polymerase (DNA directed) 2.12059
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.11984
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 2.11718
SFRP1 secreted frizzled-related protein 1 2.10826
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 2.10731
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 2.10425
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 2.08766
ACAA1 acetyl-CoA acyltransferase 1 2.05734
OSMR oncostatin M receptor 2.04321
CEP170 centrosomal protein 170kDa 2.02474
EMC2 ER membrane protein complex subunit 2 2.02158

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.9745
CYCS cytochrome c, somatic -3.90423
GADD45B growth arrest and DNA-damage-inducible, beta -3.70814
GNAS GNAS complex locus -3.61178
MRPS16 mitochondrial ribosomal protein S16 -3.33441
SORBS3 sorbin and SH3 domain containing 3 -3.28909
ETFB electron-transfer-flavoprotein, beta polypeptide -3.2856
ATF5 activating transcription factor 5 -3.21769
PCCB propionyl CoA carboxylase, beta polypeptide -3.11224
PRPF4 pre-mRNA processing factor 4 -3.09012
S100A8 S100 calcium binding protein A8 -3.00534
VDAC1 voltage-dependent anion channel 1 -2.8379
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.63993
MSMO1 methylsterol monooxygenase 1 -2.63063
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.58173
RALGDS ral guanine nucleotide dissociation stimulator -2.5348
ANXA2 annexin A2 -2.51473
ATP5F1E ATP synthase F1 subunit epsilon -2.47028
RPL38 ribosomal protein L38 -2.3532
SGK1 serum/glucocorticoid regulated kinase 1 -2.31646
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 -2.29387
TES testin LIM domain protein -2.25818
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.20339
EMC3 ER membrane protein complex subunit 3 -2.19556
HSPA8 heat shock 70kDa protein 8 -2.16782
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 -2.16545
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.1631
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.16261
TTLL1 tubulin tyrosine ligase-like family member 1 -2.15
RFXANK regulatory factor X-associated ankyrin-containing protein -2.1433
USB1 U6 snRNA biogenesis 1 -2.10012
SSR4 signal sequence receptor, delta -2.09975
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 -2.09321
ADGRE5 adhesion G protein-coupled receptor E5 -2.08491
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.08447
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.07281
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.0497
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.03402
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) -2.00073