CRCGN017_MCF10A.WT.HP_24H:C06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description leflunomide 11.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:C06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCP110 centriolar coiled coil protein 110kDa 4.13993
CERK ceramide kinase 4.10586
CIAO3 cytosolic iron-sulfur assembly component 3 3.73716
SNAP25 synaptosomal-associated protein, 25kDa 3.69584
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.67316
BZW2 basic leucine zipper and W2 domains 2 3.31488
SPAG4 sperm associated antigen 4 3.30257
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 3.01348
ABHD6 abhydrolase domain containing 6 3.00893
STK10 serine/threonine kinase 10 2.93559
SSBP2 single-stranded DNA binding protein 2 2.77732
ACAA1 acetyl-CoA acyltransferase 1 2.15514
MTA2 metastasis associated 1 family, member 2 2.04648
TIAM1 T-cell lymphoma invasion and metastasis 1 2.03398

decreased expression

Symbol Name Standardized Value
LRP10 low density lipoprotein receptor-related protein 10 -4.42053
WASHC5 WASH complex subunit 5 -3.61434
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.43457
KIF14 kinesin family member 14 -3.36973
CHIC2 cysteine-rich hydrophobic domain 2 -3.36362
RNF167 ring finger protein 167 -3.31125
TRAPPC3 trafficking protein particle complex 3 -3.21271
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.18317
MSN moesin -2.89317
KRT14 keratin 14, type I -2.85663
PARP2 poly (ADP-ribose) polymerase 2 -2.66338
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.59238
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.52725
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.37686
RPA3 replication protein A3, 14kDa -2.29661
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 -2.14331
ANXA2 annexin A2 -2.07934
VAT1 vesicle amine transport 1 -2.07531
PFN1 profilin 1 -2.06507
CD81 CD81 molecule -2.06027
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -2.0006