CRCGN017_MCF10A.WT.HP_24H:C08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sr1664 3.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

140 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:C08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 5.03687
ABHD4 abhydrolase domain containing 4 4.9268
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.83432
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.5248
RSF1 remodeling and spacing factor 1 3.44125
WASF3 WAS protein family, member 3 3.424
CLNS1A chloride channel, nucleotide-sensitive, 1A 3.4036
FZD7 frizzled class receptor 7 3.2844
ACAA1 acetyl-CoA acyltransferase 1 3.14437
NRBF2 nuclear receptor binding factor 2 3.07675
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 3.07275
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 3.0103
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.8993
ECD ecdysoneless homolog (Drosophila) 2.7876
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.77755
CHEK2 checkpoint kinase 2 2.76273
DROSHA drosha, ribonuclease type III 2.6684
WAPL WAPL cohesin release factor 2.44265
NUP42 nucleoporin 42 2.4242
FLT3 fms-related tyrosine kinase 3 2.3983
ERCC6 excision repair cross-complementation group 6 2.3743
MYH9 myosin, heavy chain 9, non-muscle 2.33335
UGDH UDP-glucose 6-dehydrogenase 2.30435
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 2.2441
INTS6 integrator complex subunit 6 2.1994
PKN1 protein kinase N1 2.18132
BRIX1 BRX1, biogenesis of ribosomes 2.17025
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 2.1457
ZNF143 zinc finger protein 143 2.11855
FAM193A family with sequence similarity 193, member A 2.1025
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.10095
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.09835
ZBTB35 zinc finger and BTB domain containing 35 2.08875
STK26 serine/threonine protein kinase 26 2.08215
GSPT2 G1 to S phase transition 2 2.0769
MAGEB2 melanoma antigen family B2 2.07275
ZWILCH zwilch kinetochore protein 2.06205
SKA1 spindle and kinetochore associated complex subunit 1 2.0442
HJURP Holliday junction recognition protein 2.04345
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 2.04208
RAB13 RAB13, member RAS oncogene family 2.0355
SAV1 salvador family WW domain containing protein 1 2.03495
GIN1 gypsy retrotransposon integrase 1 2.02685
NUP205 nucleoporin 205kDa 2.01745
DLC1 DLC1 Rho GTPase activating protein 2.01341
BLTP3B bridge-like lipid transfer protein family member 3B 2.01195
RIOK2 RIO kinase 2 2.0028

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -10.0
PCCB propionyl CoA carboxylase, beta polypeptide -4.73715
ATF5 activating transcription factor 5 -4.51155
UBE3C ubiquitin protein ligase E3C -4.36315
LORICRIN loricrin cornified envelope precursor protein -4.33155
GDF15 growth differentiation factor 15 -4.32755
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.2713
CLTB clathrin, light chain B -4.06321
PFN1 profilin 1 -3.6561
CANT1 calcium activated nucleotidase 1 -3.60945
KRT2 keratin 2, type II -3.59445
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.57845
FAIM Fas apoptotic inhibitory molecule -3.56195
KRT1 keratin 1, type II -3.2275
RGS2 regulator of G-protein signaling 2 -3.1562
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.0013
RALGDS ral guanine nucleotide dissociation stimulator -2.95653
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1 -2.95615
KCNK7 potassium channel, two pore domain subfamily K, member 7 -2.9083
NGRN neugrin, neurite outgrowth associated -2.83955
ESRP2 epithelial splicing regulatory protein 2 -2.76265
CALML5 calmodulin-like 5 -2.7375
LY6D lymphocyte antigen 6 complex, locus D -2.7365
OAT ornithine aminotransferase -2.7145
BAD BCL2-associated agonist of cell death -2.68257
CMTR1 cap methyltransferase 1 -2.67485
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.65062
DSG1 desmoglein 1 -2.62625
ABHD14A abhydrolase domain containing 14A -2.5996
LCE2B late cornified envelope 2B -2.5665
KRT31 keratin 31, type I -2.566
CCL27 chemokine (C-C motif) ligand 27 -2.5603
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa -2.53985
FLG filaggrin -2.50355
KRT33A keratin 33A, type I -2.5031
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -2.4937
AQP3 aquaporin 3 (Gill blood group) -2.45598
SLURP1 secreted LY6/PLAUR domain containing 1 -2.44925
LGALS7B lectin, galactoside-binding, soluble, 7B -2.4322
TFCP2L1 transcription factor CP2-like 1 -2.43045
ZNF76 zinc finger protein 76 -2.35295
PLPPR4 phospholipid phosphatase related 4 -2.3233
PERP PERP, TP53 apoptosis effector -2.3188
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa -2.3112
S100A14 S100 calcium binding protein A14 -2.2899
KLHDC8A kelch domain containing 8A -2.28295
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 -2.27905
SPINK5 serine peptidase inhibitor, Kazal type 5 -2.27745
CEP70 centrosomal protein 70kDa -2.2713
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.2596
IGFBP5 insulin-like growth factor binding protein 5 -2.24818
FAM3A family with sequence similarity 3, member A -2.2189
SMIM10L1 small integral membrane protein 10 like 1 -2.2074
TRIM39-RPP21 TRIM39-RPP21 readthrough -2.1996
ARID4B AT rich interactive domain 4B (RBP1-like) -2.1986
ZNF688 zinc finger protein 688 -2.19812
CDHR1 cadherin-related family member 1 -2.19485
POF1B premature ovarian failure, 1B -2.179
MEA1 male-enhanced antigen 1 -2.17625
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 -2.17355
CXCL14 chemokine (C-X-C motif) ligand 14 -2.1664
KRT9 keratin 9, type I -2.15205
XKR8 XK, Kell blood group complex subunit-related family, member 8 -2.13805
KAT2A K(lysine) acetyltransferase 2A -2.1333
PHF1 PHD finger protein 1 -2.12965
MNX1 motor neuron and pancreas homeobox 1 -2.1293
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.12795
EMC3 ER membrane protein complex subunit 3 -2.1161
SNRPC small nuclear ribonucleoprotein polypeptide C -2.1087
ARMC7 armadillo repeat containing 7 -2.1078
FCGBP Fc fragment of IgG binding protein -2.1054
EIF2D eukaryotic translation initiation factor 2D -2.1029
TYRP1 tyrosinase-related protein 1 -2.1016
SPINK4 serine peptidase inhibitor, Kazal type 4 -2.0985
NDRG4 NDRG family member 4 -2.09415
KLK1 kallikrein 1 -2.0927
ANGPT1 angiopoietin 1 -2.09153
CHP2 calcineurin-like EF-hand protein 2 -2.09115
IBSP integrin-binding sialoprotein -2.08835
CREG1 cellular repressor of E1A-stimulated genes 1 -2.0811
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -2.06995
INSM1 insulinoma-associated 1 -2.0679
KDM3A lysine (K)-specific demethylase 3A -2.0663
PROX1 prospero homeobox 1 -2.04905
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 -2.04618
GJD2 gap junction protein, delta 2, 36kDa -2.0406
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.03875
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 -2.02475
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 -2.02385
PDGFD platelet derived growth factor D -2.02265
TREM1 triggering receptor expressed on myeloid cells 1 -2.01405
FGFBP1 fibroblast growth factor binding protein 1 -2.0119
EPHX3 epoxide hydrolase 3 -2.0086