CRCGN017_MCF10A.WT.HP_24H:C12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description lg100268 1.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

38 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:C12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TATDN2 TatD DNase domain containing 2 5.56775
ABHD4 abhydrolase domain containing 4 5.15835
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 4.55585
TBPL1 TBP-like 1 3.7073
RSU1 Ras suppressor protein 1 3.0095
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.73415
TCEA2 transcription elongation factor A (SII), 2 2.5777
SNX11 sorting nexin 11 2.41777
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.33455
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.17875
NUP37 nucleoporin 37kDa 2.162
TEX10 testis expressed 10 2.1028
CCNF cyclin F 2.10133
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 2.0624
FCHO1 FCH domain only 1 2.0551
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 2.0441
HOXA10 homeobox A10 2.04047
ATP5F1C ATP synthase F1 subunit gamma 2.03237
CBX1 chromobox homolog 1 2.02725
CNRIP1 cannabinoid receptor interacting protein 1 2.02075
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 2.0139

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -5.0
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.94995
KIF14 kinesin family member 14 -4.81675
TES testin LIM domain protein -4.63013
CD44 CD44 molecule (Indian blood group) -4.47979
SGK1 serum/glucocorticoid regulated kinase 1 -3.7714
LYPLA1 lysophospholipase I -3.30743
MT2A metallothionein 2A -3.13205
CTNND1 catenin (cadherin-associated protein), delta 1 -3.0894
IGFBP7 insulin-like growth factor binding protein 7 -2.90258
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.85965
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.78723
MT1X metallothionein 1X -2.45622
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.3333
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.10735
KRT14 keratin 14, type I -2.07
NGRN neugrin, neurite outgrowth associated -2.00865