CRCGN017_MCF10A.WT.HP_24H:C17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acrolein 34.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:C17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 6.7427
TLR4 toll-like receptor 4 5.08085
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.8194
ACAA1 acetyl-CoA acyltransferase 1 3.50952
IGHMBP2 immunoglobulin mu binding protein 2 3.20392
WIF1 WNT inhibitory factor 1 2.81175
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.6872
KCTD5 potassium channel tetramerization domain containing 5 2.6228
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.5665
HMGN3 high mobility group nucleosomal binding domain 3 2.5229
ALKBH4 alkB, alkylation repair homolog 4 (E. coli) 2.4376
SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1 2.29732
INPP5J inositol polyphosphate-5-phosphatase J 2.11555
CBR1 carbonyl reductase 1 2.1095
CDK6 cyclin-dependent kinase 6 2.09305
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12) 2.07295
BMS1 BMS1 ribosome biogenesis factor 2.0673
CT55 cancer/testis antigen 55 2.04145
ZGPAT zinc finger, CCCH-type with G patch domain 2.02128

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -4.79625
TES testin LIM domain protein -4.7704
NPDC1 neural proliferation, differentiation and control, 1 -4.69935
TNIP1 TNFAIP3 interacting protein 1 -4.6537
CANT1 calcium activated nucleotidase 1 -3.76752
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.75938
IFRD2 interferon-related developmental regulator 2 -3.40968
KRT14 keratin 14, type I -3.32995
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.6226
HSPA1A heat shock 70kDa protein 1A -2.3024
CETN2 centrin, EF-hand protein, 2 -2.25265
WASHC4 WASH complex subunit 4 -2.1125
GDF15 growth differentiation factor 15 -2.0862