CRCGN017_MCF10A.WT.HP_24H:D02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description omeprazole 33.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

81 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:D02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.24654
ABHD6 abhydrolase domain containing 6 4.1486
MCOLN1 mucolipin 1 3.29693
COL11A1 collagen, type XI, alpha 1 3.23316
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.08897
WASHC5 WASH complex subunit 5 3.0386
CIAO3 cytosolic iron-sulfur assembly component 3 2.97223
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.95793
MEF2C myocyte enhancer factor 2C 2.91829
MMP2 matrix metallopeptidase 2 2.74565
TENT4A terminal nucleotidyltransferase 4A 2.66857
HYOU1 hypoxia up-regulated 1 2.60403
BRD9 bromodomain containing 9 2.52573
RPP38 ribonuclease P/MRP 38kDa subunit 2.38955
PRCC papillary renal cell carcinoma (translocation-associated) 2.38785
PMM2 phosphomannomutase 2 2.38688
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.34363
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 2.32482
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 2.31141
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.30752
SPRED2 sprouty-related, EVH1 domain containing 2 2.26593
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.22283
SERHL2 serine hydrolase-like 2 2.20597
ZNF557 zinc finger protein 557 2.19958
E2F5 E2F transcription factor 5, p130-binding 2.19702
ALAS1 5'-aminolevulinate synthase 1 2.17746
DNAAF5 dynein, axonemal, assembly factor 5 2.16535
CDH12 cadherin 12, type 2 (N-cadherin 2) 2.16502
PPOX protoporphyrinogen oxidase 2.16184
SIRT3 sirtuin 3 2.10735
SCARF1 scavenger receptor class F, member 1 2.0982
GIMAP6 GTPase, IMAP family member 6 2.0942
TRIM46 tripartite motif containing 46 2.09322
FCHSD2 FCH and double SH3 domains 2 2.08535
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.08053
AIRE autoimmune regulator 2.08024
SOCS2 suppressor of cytokine signaling 2 2.08012
TESK1 testis-specific kinase 1 2.0712
SCAMP5 secretory carrier membrane protein 5 2.06792
RNF31 ring finger protein 31 2.06683
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 2.0586
EMCN endomucin 2.04787
APOL5 apolipoprotein L, 5 2.03865
FBXL12 F-box and leucine-rich repeat protein 12 2.03325
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.02919
ANGPTL2 angiopoietin-like 2 2.02493
ACVRL1 activin A receptor type II-like 1 2.02327
PRDM1 PR domain containing 1, with ZNF domain 2.01307
TAS2R16 taste receptor, type 2, member 16 2.00623
IL10 interleukin 10 2.00463
TIMP2 TIMP metallopeptidase inhibitor 2 2.00177
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.00162

decreased expression

Symbol Name Standardized Value
CD81 CD81 molecule -4.71119
BASP1 brain abundant, membrane attached signal protein 1 -4.08127
DSG2 desmoglein 2 -3.74828
HSPA8 heat shock 70kDa protein 8 -3.2004
MPC2 mitochondrial pyruvate carrier 2 -3.14435
TM9SF3 transmembrane 9 superfamily member 3 -2.67307
OXA1L oxidase (cytochrome c) assembly 1-like -2.64852
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.50942
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.5069
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.44019
MRPS2 mitochondrial ribosomal protein S2 -2.37533
CST3 cystatin C -2.35651
TLCD3A TLC domain containing 3A -2.34315
CORO1A coronin, actin binding protein, 1A -2.3226
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.31455
PRCP prolylcarboxypeptidase (angiotensinase C) -2.28746
SNX6 sorting nexin 6 -2.26361
UFM1 ubiquitin-fold modifier 1 -2.25492
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.23953
CMTM6 CKLF-like MARVEL transmembrane domain containing 6 -2.15999
REPS2 RALBP1 associated Eps domain containing 2 -2.15033
WASHC4 WASH complex subunit 4 -2.12595
HSPA1A heat shock 70kDa protein 1A -2.12421
TSPYL1 TSPY-like 1 -2.12029
CYBA cytochrome b-245, alpha polypeptide -2.04415
TMSB4X thymosin beta 4, X-linked -2.04263
EDF1 endothelial differentiation-related factor 1 -2.02877
MRPS33 mitochondrial ribosomal protein S33 -2.01833
TFF3 trefoil factor 3 (intestinal) -2.0011