CRCGN017_MCF10A.WT.HP_24H:D03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description omeprazole 11.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

132 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:D03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.75024
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 4.55203
IFNAR1 interferon (alpha, beta and omega) receptor 1 4.2654
MYLK myosin light chain kinase 3.36945
FAM20B family with sequence similarity 20, member B 3.28734
NCAPD2 non-SMC condensin I complex, subunit D2 3.27926
RTN2 reticulon 2 3.25703
STK10 serine/threonine kinase 10 3.21596
SSBP2 single-stranded DNA binding protein 2 2.97692
LYN LYN proto-oncogene, Src family tyrosine kinase 2.90601
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.64602
RASIP1 Ras interacting protein 1 2.58806
SPRED2 sprouty-related, EVH1 domain containing 2 2.56443
PPOX protoporphyrinogen oxidase 2.5093
ANGPT2 angiopoietin 2 2.4863
FOLR3 folate receptor 3 (gamma) 2.47547
DOC2B double C2-like domains, beta 2.43639
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.43374
HMGA1 high mobility group AT-hook 1 2.39367
PRSS23 protease, serine, 23 2.38769
VEGFB vascular endothelial growth factor B 2.37319
ZNF43 zinc finger protein 43 2.35264
RAB21 RAB21, member RAS oncogene family 2.34799
EPHB2 EPH receptor B2 2.33604
ALX4 ALX homeobox 4 2.31213
H2BC3 H2B clustered histone 3 2.30311
ZNF345 zinc finger protein 345 2.30137
FSD1 fibronectin type III and SPRY domain containing 1 2.29
VAC14 Vac14 homolog (S. cerevisiae) 2.27742
HBB hemoglobin, beta 2.27179
ANGPTL8 angiopoietin like 8 2.27106
CIAO3 cytosolic iron-sulfur assembly component 3 2.26086
STON1 stonin 1 2.25861
TP73 tumor protein p73 2.24555
CRELD2 cysteine-rich with EGF-like domains 2 2.2328
TMEM143 transmembrane protein 143 2.22374
NTF3 neurotrophin 3 2.204
DEFA5 defensin, alpha 5, Paneth cell-specific 2.20097
GATA1 GATA binding protein 1 (globin transcription factor 1) 2.19183
FCGBP Fc fragment of IgG binding protein 2.18981
THOC6 THO complex 6 2.18266
FGFR4 fibroblast growth factor receptor 4 2.17841
FANCG Fanconi anemia, complementation group G 2.17464
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 2.17459
BRME1 break repair meiotic recombinase recruitment factor 1 2.17452
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.16918
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.16804
NPDC1 neural proliferation, differentiation and control, 1 2.16601
PDGFD platelet derived growth factor D 2.16396
TRAPPC6A trafficking protein particle complex 6A 2.15813
FRMPD1 FERM and PDZ domain containing 1 2.15485
SNN stannin 2.15091
H2BC17 H2B clustered histone 17 2.13837
RAI14 retinoic acid induced 14 2.13521
TERT telomerase reverse transcriptase 2.13495
H1-4 H1.4 linker histone, cluster member 2.134
MMP15 matrix metallopeptidase 15 (membrane-inserted) 2.13064
MAP3K11 mitogen-activated protein kinase kinase kinase 11 2.12635
PRR14L proline rich 14-like 2.12402
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 2.11796
H2BC14 H2B clustered histone 14 2.11454
GFI1B growth factor independent 1B transcription repressor 2.10812
PPP6R2 protein phosphatase 6, regulatory subunit 2 2.10326
TRABD TraB domain containing 2.09775
ZNF253 zinc finger protein 253 2.0857
KIF13A kinesin family member 13A 2.0841
PCDH12 protocadherin 12 2.08335
CREB3L4 cAMP responsive element binding protein 3-like 4 2.07472
NOTCH4 notch 4 2.07248
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.06743
REG1B regenerating islet-derived 1 beta 2.06044
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 2.05815
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.05627
CXCR4 chemokine (C-X-C motif) receptor 4 2.05254
P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4 2.05103
ARL4C ADP-ribosylation factor-like 4C 2.04806
ADAM11 ADAM metallopeptidase domain 11 2.04751
H1-3 H1.3 linker histone, cluster member 2.03862
TESK1 testis-specific kinase 1 2.03774
H1-5 H1.5 linker histone, cluster member 2.03496
SCN2A sodium channel, voltage gated, type II alpha subunit 2.02148
EPHB1 EPH receptor B1 2.01574
ZNF835 zinc finger protein 835 2.01382
IGFBP3 insulin-like growth factor binding protein 3 2.01184
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 2.0111
PALMD palmdelphin 2.00882
STARD5 StAR-related lipid transfer (START) domain containing 5 2.00849
IL12RB1 interleukin 12 receptor, beta 1 2.00847
DUSP21 dual specificity phosphatase 21 2.00791
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 2.00547
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) 2.00382

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -4.59877
HSPA8 heat shock 70kDa protein 8 -4.09818
CHIC2 cysteine-rich hydrophobic domain 2 -4.0434
BAG3 BCL2-associated athanogene 3 -3.86777
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.56024
CCNB2 cyclin B2 -3.44946
CAB39 calcium binding protein 39 -3.44877
CCNB1 cyclin B1 -3.25026
GTPBP8 GTP-binding protein 8 (putative) -3.24628
TUBB6 tubulin, beta 6 class V -3.16124
ANXA2 annexin A2 -2.88078
MRPS2 mitochondrial ribosomal protein S2 -2.7389
SACS sacsin molecular chaperone -2.71734
SLC35B1 solute carrier family 35, member B1 -2.69673
TRIP12 thyroid hormone receptor interactor 12 -2.45284
GOLGA7 golgin A7 -2.44914
HSPA1A heat shock 70kDa protein 1A -2.43654
WASHC4 WASH complex subunit 4 -2.42189
MCOLN1 mucolipin 1 -2.40254
CD81 CD81 molecule -2.36035
NPC2 Niemann-Pick disease, type C2 -2.35944
SARAF store-operated calcium entry-associated regulatory factor -2.24366
CBR3 carbonyl reductase 3 -2.23272
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -2.22186
SNX6 sorting nexin 6 -2.21377
INPP1 inositol polyphosphate-1-phosphatase -2.2104
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.18706
IP6K2 inositol hexakisphosphate kinase 2 -2.1729
S100A11 S100 calcium binding protein A11 -2.16843
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.12382
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.08952
PCDHB16 protocadherin beta 16 -2.06998
TSG101 tumor susceptibility 101 -2.05757
BLVRA biliverdin reductase A -2.05005
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.04306
MLYCD malonyl-CoA decarboxylase -2.03415
THYN1 thymocyte nuclear protein 1 -2.03263
NCOA4 nuclear receptor coactivator 4 -2.01652
CLTC clathrin, heavy chain (Hc) -2.01005
MSMO1 methylsterol monooxygenase 1 -2.00864
MAGED1 melanoma antigen family D1 -2.00249