CRCGN017_MCF10A.WT.HP_24H:D06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description s26948 1.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:D06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ACAA1 acetyl-CoA acyltransferase 1 5.15055
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.50723
GRB10 growth factor receptor-bound protein 10 3.17772
STK10 serine/threonine kinase 10 2.78925
MAP7 microtubule-associated protein 7 2.4707
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.37143
NUBP2 nucleotide binding protein 2 2.04485

decreased expression

Symbol Name Standardized Value
COG2 component of oligomeric golgi complex 2 -5.32539
PCNA proliferating cell nuclear antigen -5.27421
DHRS7 dehydrogenase/reductase (SDR family) member 7 -5.19749
YME1L1 YME1-like 1 ATPase -4.47943
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) -4.37009
RNF167 ring finger protein 167 -4.35885
ETFB electron-transfer-flavoprotein, beta polypeptide -4.17455
SGK1 serum/glucocorticoid regulated kinase 1 -3.7931
SPRED2 sprouty-related, EVH1 domain containing 2 -3.56674
PFN1 profilin 1 -3.30611
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.80892
MRPS2 mitochondrial ribosomal protein S2 -2.74066
MSMO1 methylsterol monooxygenase 1 -2.66357
HAT1 histone acetyltransferase 1 -2.53092
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.51089
UBE3C ubiquitin protein ligase E3C -2.41599
TM9SF3 transmembrane 9 superfamily member 3 -2.374
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.27504
HMG20B high mobility group 20B -2.25724
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 -2.22228
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -2.16022
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 -2.09354
VDAC1 voltage-dependent anion channel 1 -2.08591
EIF3L eukaryotic translation initiation factor 3, subunit L -2.07766