CRCGN017_MCF10A.WT.HP_24H:D08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tretinoin 3.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:D08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HOXA5 homeobox A5 6.47765
MAMLD1 mastermind-like domain containing 1 4.8781
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.8676
TCEA2 transcription elongation factor A (SII), 2 3.7212
HBB hemoglobin, beta 3.47373
BAG3 BCL2-associated athanogene 3 3.3645
FHL2 four and a half LIM domains 2 3.2862
NOSIP nitric oxide synthase interacting protein 2.97755
PLS1 plastin 1 2.95985
HBA1 hemoglobin, alpha 1 2.94635
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.70215
CCDC59 coiled-coil domain containing 59 2.56275
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.5187
TSPAN6 tetraspanin 6 2.4925
MICALL1 MICAL-like 1 2.3803
CCL2 chemokine (C-C motif) ligand 2 2.32475
ADGRE5 adhesion G protein-coupled receptor E5 2.32465
NRIP1 nuclear receptor interacting protein 1 2.31737
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 2.27965
MCUR1 mitochondrial calcium uniporter regulator 1 2.25675
HIGD1A HIG1 hypoxia inducible domain family, member 1A 2.22787
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.22073
TSC22D1 TSC22 domain family, member 1 2.1823
HOXA1 homeobox A1 2.1706
STAMBP STAM binding protein 2.1255
PLAT plasminogen activator, tissue 2.12265
PLSCR1 phospholipid scramblase 1 2.1053
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 2.10295
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.1027
ITK IL2-inducible T-cell kinase 2.0696
IL1B interleukin 1, beta 2.06052
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 2.01575
MPHOSPH6 M-phase phosphoprotein 6 2.00175

decreased expression

Symbol Name Standardized Value
S100A8 S100 calcium binding protein A8 -5.0
NUP85 nucleoporin 85kDa -4.8257
PCNA proliferating cell nuclear antigen -4.81085
YME1L1 YME1-like 1 ATPase -4.74125
LLGL2 lethal giant larvae homolog 2 (Drosophila) -3.5209
CDR2L cerebellar degeneration-related protein 2-like -3.46635
TMEM94 transmembrane protein 94 -3.34935
KCTD2 potassium channel tetramerization domain containing 2 -3.14003
SLC38A12 solute carrier family 38 member 12 -2.7152
CASKIN2 CASK interacting protein 2 -2.57233
ATG3 autophagy related 3 -2.52185
FDXR ferredoxin reductase -2.50095
GRB2 growth factor receptor-bound protein 2 -2.46515
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.4592
ABI1 abl-interactor 1 -2.4558
S100A4 S100 calcium binding protein A4 -2.43555
SAP30BP SAP30 binding protein -2.4305
BASP1 brain abundant, membrane attached signal protein 1 -2.3327
FAT1 FAT atypical cadherin 1 -2.26225
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.25643
CYBC1 cytochrome b-245 chaperone 1 -2.19045
MEGF8 multiple EGF-like-domains 8 -2.17865
TMEM80 transmembrane protein 80 -2.16447
PDGFRB platelet-derived growth factor receptor, beta polypeptide -2.13065
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 -2.11325
SUMO4 small ubiquitin-like modifier 4 -2.09925
GPRC5C G protein-coupled receptor, class C, group 5, member C -2.0945
ALG12 ALG12, alpha-1,6-mannosyltransferase -2.0905
EXPH5 exophilin 5 -2.05687
HDAC5 histone deacetylase 5 -2.04825
MAVS mitochondrial antiviral signaling protein -2.0474
CTC1 CTS telomere maintenance complex component 1 -2.0464
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.04065
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.0319
ELOVL4 ELOVL fatty acid elongase 4 -2.02095
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.0123
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial -2.0085