CRCGN017_MCF10A.WT.HP_24H:D09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tretinoin 1.11 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:D09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HOXA5 homeobox A5 5.98515
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 5.53805
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.1113
TCEA2 transcription elongation factor A (SII), 2 4.1117
SSBP2 single-stranded DNA binding protein 2 3.55212
BAG3 BCL2-associated athanogene 3 3.1098
ACAA1 acetyl-CoA acyltransferase 1 2.70965
TENT4A terminal nucleotidyltransferase 4A 2.64365
EDNRB endothelin receptor type B 2.55622
FHL2 four and a half LIM domains 2 2.5059
HBB hemoglobin, beta 2.45513
NRIP1 nuclear receptor interacting protein 1 2.36832
ELOVL6 ELOVL fatty acid elongase 6 2.22085
SMAD3 SMAD family member 3 2.21312
IL13RA1 interleukin 13 receptor, alpha 1 2.20123
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.17095
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.10795
TSPAN6 tetraspanin 6 2.07853
PLSCR1 phospholipid scramblase 1 2.06557
CGRRF1 cell growth regulator with ring finger domain 1 2.017
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A 2.00545

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -5.45145
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -4.6502
TLCD3A TLC domain containing 3A -4.14955
PMM2 phosphomannomutase 2 -3.9197
PHKA1 phosphorylase kinase, alpha 1 (muscle) -3.7689
MSN moesin -3.32675
HS1BP3 HCLS1 binding protein 3 -2.8508
ERGIC2 ERGIC and golgi 2 -2.83355
KRT14 keratin 14, type I -2.73105
WASHC4 WASH complex subunit 4 -2.55857
NCAPD2 non-SMC condensin I complex, subunit D2 -2.5437
INTS13 integrator complex subunit 13 -2.53185
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -2.4886
S100A4 S100 calcium binding protein A4 -2.39935
SDK2 sidekick cell adhesion molecule 2 -2.3568
TMEM186 transmembrane protein 186 -2.3555
CAPRIN2 caprin family member 2 -2.257
PSORS1C2 psoriasis susceptibility 1 candidate 2 -2.22315
OXA1L oxidase (cytochrome c) assembly 1-like -2.2222
DUSP14 dual specificity phosphatase 14 -2.2013
RPS5 ribosomal protein S5 -2.1867
RESF1 retroelement silencing factor 1 -2.1558
TPPP tubulin polymerization promoting protein -2.127
HSPA1A heat shock 70kDa protein 1A -2.0909
DNTT DNA nucleotidylexotransferase -2.0891
TM9SF2 transmembrane 9 superfamily member 2 -2.08545
TKT transketolase -2.0799
PLCB4 phospholipase C, beta 4 -2.06997
DMTN dematin actin binding protein -2.06525
RGS2 regulator of G-protein signaling 2 -2.0571
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.0336
CTSV cathepsin V -2.02975
HPS4 Hermansky-Pudlak syndrome 4 -2.00155