CRCGN017_MCF10A.WT.HP_24H:D14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description galangin with tcdd perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

84 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:D14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.85
LOXL1 lysyl oxidase-like 1 5.34075
ADAM10 ADAM metallopeptidase domain 10 4.91902
WIF1 WNT inhibitory factor 1 3.1588
DHDDS dehydrodolichyl diphosphate synthase 2.85355
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.8489
GPATCH8 G patch domain containing 8 2.67173
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 2.64225
PARN poly(A)-specific ribonuclease 2.54475
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.437
AGO1 argonaute RISC catalytic component 1 2.37285
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.3699
SLC25A46 solute carrier family 25, member 46 2.28695
AP3M2 adaptor-related protein complex 3, mu 2 subunit 2.0865
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 2.01725
KIF1B kinesin family member 1B 2.0126

decreased expression

Symbol Name Standardized Value
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.11955
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.8335
ISOC1 isochorismatase domain containing 1 -4.6585
SGK1 serum/glucocorticoid regulated kinase 1 -4.6503
KIF20A kinesin family member 20A -4.1722
CANT1 calcium activated nucleotidase 1 -4.0888
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.9781
PSENEN presenilin enhancer gamma secretase subunit -3.08965
GDF15 growth differentiation factor 15 -3.0371
ACAA1 acetyl-CoA acyltransferase 1 -2.95033
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.9228
LIN37 lin-37 DREAM MuvB core complex component -2.8895
NKX2-5 NK2 homeobox 5 -2.86225
HSPA1A heat shock 70kDa protein 1A -2.85125
RNF123 ring finger protein 123 -2.68685
BAD BCL2-associated agonist of cell death -2.67095
CDC20 cell division cycle 20 -2.61835
MYLK3 myosin light chain kinase 3 -2.57395
TCAP titin-cap -2.5024
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 -2.4999
PLK1 polo-like kinase 1 -2.4829
OSGIN2 oxidative stress induced growth inhibitor family member 2 -2.47085
DES desmin -2.45858
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 -2.4317
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.42095
GAMT guanidinoacetate N-methyltransferase -2.39825
PRLH prolactin releasing hormone -2.36435
FOXL2 forkhead box L2 -2.3488
RAB40C RAB40C, member RAS oncogene family -2.3437
MYL2 myosin, light chain 2, regulatory, cardiac, slow -2.34095
DYNLT1 dynein, light chain, Tctex-type 1 -2.33865
CKM creatine kinase, muscle -2.3099
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -2.3098
IL18R1 interleukin 18 receptor 1 -2.2971
HPS6 Hermansky-Pudlak syndrome 6 -2.27735
ZNF516 zinc finger protein 516 -2.26855
LDB3 LIM domain binding 3 -2.21537
NKG7 natural killer cell granule protein 7 -2.20805
TNNC2 troponin C type 2 (fast) -2.20225
ITGA9 integrin, alpha 9 -2.19055
TBCB tubulin folding cofactor B -2.18055
GDF7 growth differentiation factor 7 -2.1787
GSTA1 glutathione S-transferase alpha 1 -2.1698
KLHL41 kelch-like family member 41 -2.15205
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -2.15175
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 -2.13995
CCDC198 coiled-coil domain containing 198 -2.12915
FKRP fukutin related protein -2.12095
ART3 ADP-ribosyltransferase 3 -2.1188
HCRT hypocretin (orexin) neuropeptide precursor -2.1181
HAPLN2 hyaluronan and proteoglycan link protein 2 -2.11765
MYL11 myosin light chain 11 -2.10445
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.1037
SEC14L4 SEC14-like 4 (S. cerevisiae) -2.08795
TNNI1 troponin I type 1 (skeletal, slow) -2.08355
CSF2 colony stimulating factor 2 (granulocyte-macrophage) -2.0799
MYH7 myosin, heavy chain 7, cardiac muscle, beta -2.07105
KMT2B lysine (K)-specific methyltransferase 2B -2.07008
CUBN cubilin (intrinsic factor-cobalamin receptor) -2.0693
MYL1 myosin, light chain 1, alkali; skeletal, fast -2.06535
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -2.0636
SYNPO2L synaptopodin 2-like -2.06105
RNF32 ring finger protein 32 -2.04385
HIRA histone cell cycle regulator -2.0395
LOC122539214 Zinc finger protein LOC122539214 -2.03325
A1CF APOBEC1 complementation factor -2.0233
UPB1 ureidopropionase, beta -2.0135
H1-3 H1.3 linker histone, cluster member -2.00625