CRCGN017_MCF10A.WT.HP_24H:D17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorpropamide 33.49 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:D17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PROS1 protein S (alpha) 5.4261
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 4.54523
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.48
TPD52L2 tumor protein D52-like 2 3.6364
ADRB2 adrenoceptor beta 2, surface 3.58415
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.93275
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.6787
DENND2D DENN/MADD domain containing 2D 2.5465
SESN1 sestrin 1 2.45975
ZMIZ1 zinc finger, MIZ-type containing 1 2.0486
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.0339

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -6.15775
TNIP1 TNFAIP3 interacting protein 1 -5.3069
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -4.7655
PUF60 poly-U binding splicing factor 60KDa -4.60065
ARID4B AT rich interactive domain 4B (RBP1-like) -3.3858
NLRP4 NLR family, pyrin domain containing 4 -3.1252
SCRIB scribbled planar cell polarity protein -2.80675
CORO1A coronin, actin binding protein, 1A -2.6244
CREG1 cellular repressor of E1A-stimulated genes 1 -2.54745
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 -2.399
REXO2 RNA exonuclease 2 -2.38969
BPI bactericidal/permeability-increasing protein -2.2923
FBXL6 F-box and leucine-rich repeat protein 6 -2.2583
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.25475
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.23885
RGS2 regulator of G-protein signaling 2 -2.21325
MMP8 matrix metallopeptidase 8 -2.16845
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.13665
FBXO21 F-box protein 21 -2.13225
PYCR3 pyrroline-5-carboxylate reductase 3 -2.1252
RETN resistin -2.0865
SAP30L SAP30-like -2.0388
GALR3 galanin receptor 3 -2.01155
POMC proopiomelanocortin -2.00745