CRCGN017_MCF10A.WT.HP_24H:D18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorpropamide 11.16 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:D18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.5096
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.9923
WIF1 WNT inhibitory factor 1 4.8329
VAV3 vav 3 guanine nucleotide exchange factor 3.59062
KIF5C kinesin family member 5C 3.2206
HBB hemoglobin, beta 2.83807
TPD52L2 tumor protein D52-like 2 2.68745
OLFML2B olfactomedin-like 2B 2.2862
FBXO11 F-box protein 11 2.10605
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 2.0396

decreased expression

Symbol Name Standardized Value
GOLT1B golgi transport 1B -5.1662
TUBB6 tubulin, beta 6 class V -4.9546
MAPK13 mitogen-activated protein kinase 13 -4.78658
CCDC86 coiled-coil domain containing 86 -4.6457
TLCD3A TLC domain containing 3A -4.54665
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.50842
CD44 CD44 molecule (Indian blood group) -4.21223
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.68695
NGRN neugrin, neurite outgrowth associated -3.54085
PHKA1 phosphorylase kinase, alpha 1 (muscle) -3.382
ARID4B AT rich interactive domain 4B (RBP1-like) -3.1182
MUL1 mitochondrial E3 ubiquitin protein ligase 1 -2.6454
ANXA2 annexin A2 -2.54165
ANGPTL4 angiopoietin-like 4 -2.51445
LINC02762 long intergenic non-protein coding RNA 2762 -2.4077
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.35765
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.32675
MT2A metallothionein 2A -2.28525
ZFPM1 zinc finger protein, FOG family member 1 -2.2763
WASHC4 WASH complex subunit 4 -2.26387
GDF15 growth differentiation factor 15 -2.1588
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -2.12827
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -2.1147
MAN1C1 mannosidase, alpha, class 1C, member 1 -2.08833
VEGFB vascular endothelial growth factor B -2.0233
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 -2.00895
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.0019