CRCGN017_MCF10A.WT.HP_24H:D20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-aminofluorene 33.05 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

22 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:D20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.32015
ZBTB35 zinc finger and BTB domain containing 35 4.276
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.06605
HMOX1 heme oxygenase 1 4.02835
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.95435
STAP2 signal transducing adaptor family member 2 3.09865
ZW10 zw10 kinetochore protein 3.0628
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.9984
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.11505

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -7.8241
TM9SF3 transmembrane 9 superfamily member 3 -5.55245
KIF14 kinesin family member 14 -5.22515
WASHC4 WASH complex subunit 4 -3.22672
CD81 CD81 molecule -3.20625
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.86405
ACAA1 acetyl-CoA acyltransferase 1 -2.5529
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.47005
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.39057
NT5DC2 5'-nucleotidase domain containing 2 -2.3766
BAD BCL2-associated agonist of cell death -2.2938
PRCP prolylcarboxypeptidase (angiotensinase C) -2.06445
RGS2 regulator of G-protein signaling 2 -2.01785