CRCGN017_MCF10A.WT.HP_24H:D22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethoxybenzidine.2hcl 96.28 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

80 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:D22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 5.2019
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.0
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.8194
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.70885
INSIG1 insulin induced gene 1 4.12295
PRAF2 PRA1 domain family, member 2 3.2733
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.1917
FBXO7 F-box protein 7 3.1514
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.03805
FGFR4 fibroblast growth factor receptor 4 2.88905
NPY1R neuropeptide Y receptor Y1 2.6879
HOXA5 homeobox A5 2.63115
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.5431
ACLY ATP citrate lyase 2.46698
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 2.44905
CBR1 carbonyl reductase 1 2.3238
VAT1 vesicle amine transport 1 2.2904
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.26918
TCIM transcriptional and immune response regulator 2.2147
MYL5 myosin, light chain 5, regulatory 2.21305
CSNK1A1 casein kinase 1, alpha 1 2.2038
IFI30 interferon, gamma-inducible protein 30 2.1783
HHAT hedgehog acyltransferase 2.16235
ORAI3 ORAI calcium release-activated calcium modulator 3 2.15375
NPY5R neuropeptide Y receptor Y5 2.14165
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.1301
GLRX glutaredoxin (thioltransferase) 2.09758
TBXA2R thromboxane A2 receptor 2.08421
S100A4 S100 calcium binding protein A4 2.0654
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.046
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.0317
HLA-DRA major histocompatibility complex, class II, DR alpha 2.0304
MAGED2 melanoma antigen family D2 2.0156
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 2.0042

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -8.4689
DERA deoxyribose-phosphate aldolase (putative) -5.3302
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -5.29425
RPIA ribose 5-phosphate isomerase A -5.08015
OXA1L oxidase (cytochrome c) assembly 1-like -4.81125
PMM2 phosphomannomutase 2 -4.2116
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.0978
CLTB clathrin, light chain B -3.78127
IGFBP7 insulin-like growth factor binding protein 7 -3.68375
LYPLA1 lysophospholipase I -3.6542
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.3722
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.83992
ACAA1 acetyl-CoA acyltransferase 1 -2.82382
ANXA8L1 annexin A8-like 1 -2.6401
PHKA1 phosphorylase kinase, alpha 1 (muscle) -2.54
ZNF586 zinc finger protein 586 -2.5387
S100A8 S100 calcium binding protein A8 -2.53
KLK11 kallikrein-related peptidase 11 -2.515
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.48005
PRKX protein kinase, X-linked -2.47528
MRTO4 mRNA turnover 4 homolog (S. cerevisiae) -2.4197
CDC45 cell division cycle 45 -2.393
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -2.3696
ISLR immunoglobulin superfamily containing leucine-rich repeat -2.36085
ADRB2 adrenoceptor beta 2, surface -2.3577
KLK8 kallikrein-related peptidase 8 -2.29155
LINC02762 long intergenic non-protein coding RNA 2762 -2.28277
ZNF551 zinc finger protein 551 -2.24605
RABGGTB Rab geranylgeranyltransferase, beta subunit -2.22977
RBMS2 RNA binding motif, single stranded interacting protein 2 -2.1237
FXN frataxin -2.1217
LAMP5 lysosomal-associated membrane protein family, member 5 -2.11735
MRPL15 mitochondrial ribosomal protein L15 -2.1075
FLG filaggrin -2.10615
HRAS Harvey rat sarcoma viral oncogene homolog -2.10335
POLR1F RNA polymerase I subunit F -2.0966
TRIM5 tripartite motif containing 5 -2.0951
PPDPF pancreatic progenitor cell differentiation and proliferation factor -2.08175
LGI1 leucine-rich, glioma inactivated 1 -2.0809
KLK10 kallikrein-related peptidase 10 -2.07908
TEDC2 tubulin epsilon and delta complex 2 -2.0719
EVI2B ecotropic viral integration site 2B -2.0618
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 -2.0495
PLSCR1 phospholipid scramblase 1 -2.0495
SNCAIP synuclein, alpha interacting protein -2.02675
KLK13 kallikrein-related peptidase 13 -2.02658