CRCGN017_MCF10A.WT.HP_24H:E01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phosphonium sulfate 101.98 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

564 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:E01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 7.53607
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 6.67511
TXNRD1 thioredoxin reductase 1 5.70453
TLR4 toll-like receptor 4 5.50282
RAP1GAP RAP1 GTPase activating protein 5.27356
GLRX glutaredoxin (thioltransferase) 5.24975
LRP10 low density lipoprotein receptor-related protein 10 5.17544
CNRIP1 cannabinoid receptor interacting protein 1 5.05592
MVP major vault protein 4.54354
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 4.42174
ABHD4 abhydrolase domain containing 4 4.02152
SLC35B1 solute carrier family 35, member B1 3.92739
CDPF1 cysteine-rich, DPF motif domain containing 1 3.88181
WFS1 Wolfram syndrome 1 (wolframin) 3.69991
NIT1 nitrilase 1 3.47944
STX4 syntaxin 4 3.46499
CXCR4 chemokine (C-X-C motif) receptor 4 3.46213
HMOX1 heme oxygenase 1 3.35962
DUSP14 dual specificity phosphatase 14 3.30075
TIMP2 TIMP metallopeptidase inhibitor 2 3.28536
PLA2G15 phospholipase A2, group XV 3.1959
HYOU1 hypoxia up-regulated 1 3.16983
CARMIL1 capping protein regulator and myosin 1 linker 1 3.08896
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.08632
AGR2 anterior gradient 2 3.07361
CANT1 calcium activated nucleotidase 1 3.01419
IGHMBP2 immunoglobulin mu binding protein 2 3.01133
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.99942
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.99898
NCSTN nicastrin 2.99159
MISP mitotic spindle positioning 2.97352
STXBP1 syntaxin binding protein 1 2.94326
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.93142
N4BP3 NEDD4 binding protein 3 2.87407
TNIP1 TNFAIP3 interacting protein 1 2.8694
SYNE2 spectrin repeat containing, nuclear envelope 2 2.85419
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.82058
MAP7 microtubule-associated protein 7 2.81838
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.79946
DOK7 docking protein 7 2.79648
CRELD2 cysteine-rich with EGF-like domains 2 2.77742
PGPEP1 pyroglutamyl-peptidase I 2.76414
RBKS ribokinase 2.7574
ARSA arylsulfatase A 2.74906
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.73241
CLTC clathrin, heavy chain (Hc) 2.7291
WASHC5 WASH complex subunit 5 2.6983
TCEA2 transcription elongation factor A (SII), 2 2.69459
FOXO4 forkhead box O4 2.68546
HPSE heparanase 2.68128
DGKD diacylglycerol kinase, delta 130kDa 2.65861
MOGS mannosyl-oligosaccharide glucosidase 2.64892
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.64314
TBXA2R thromboxane A2 receptor 2.63338
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1 2.62998
FOSL2 FOS-like antigen 2 2.62799
CALCOCO1 calcium binding and coiled-coil domain 1 2.60131
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 2.59613
LOXL1 lysyl oxidase-like 1 2.58308
KRT8 keratin 8, type II 2.55699
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 2.52814
ZC3H12A zinc finger CCCH-type containing 12A 2.52665
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.52411
TM4SF20 transmembrane 4 L six family member 20 2.52401
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.51984
LTB lymphotoxin beta (TNF superfamily, member 3) 2.51687
DNAH2 dynein, axonemal, heavy chain 2 2.50799
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.49985
MINDY1 MINDY lysine 48 deubiquitinase 1 2.49283
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.49046
PSG2 pregnancy specific beta-1-glycoprotein 2 2.48697
WNT11 wingless-type MMTV integration site family, member 11 2.48068
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.47695
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 2.46518
SPATA20 spermatogenesis associated 20 2.45955
ERBB2 erb-b2 receptor tyrosine kinase 2 2.44159
IDUA iduronidase, alpha-L- 2.43531
TMEM94 transmembrane protein 94 2.43366
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 2.43321
MAP3K7CL MAP3K7 C-terminal like 2.43111
GSDMB gasdermin B 2.43035
HBB hemoglobin, beta 2.42438
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.42241
OSGIN1 oxidative stress induced growth inhibitor 1 2.41623
PRSS8 protease, serine, 8 2.41202
TUFT1 tuftelin 1 2.41041
TP53I3 tumor protein p53 inducible protein 3 2.406
MYH9 myosin, heavy chain 9, non-muscle 2.3998
FURIN furin (paired basic amino acid cleaving enzyme) 2.39504
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 2.39245
CD22 CD22 molecule 2.39131
C2CD2 C2 calcium-dependent domain containing 2 2.36985
ACAA1 acetyl-CoA acyltransferase 1 2.36459
PDGFD platelet derived growth factor D 2.35737
DHX32 DEAH (Asp-Glu-Ala-His) box polypeptide 32 2.35434
CCS copper chaperone for superoxide dismutase 2.35246
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 2.34219
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 2.34144
KIAA0319 KIAA0319 2.34106
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.33812
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.33151
DES desmin 2.32987
APOA4 apolipoprotein A-IV 2.32044
GPX2 glutathione peroxidase 2 2.31883
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 2.3072
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 2.30486
PRAMEF10 PRAME family member 10 2.30232
TMEM53 transmembrane protein 53 2.29773
SCRN1 secernin 1 2.29608
BLVRB biliverdin reductase B 2.29487
MUC13 mucin 13, cell surface associated 2.29249
PPOX protoporphyrinogen oxidase 2.29055
KRT18 keratin 18, type I 2.2892
TSNAXIP1 translin-associated factor X interacting protein 1 2.28772
EZR ezrin 2.28558
DNAH3 dynein, axonemal, heavy chain 3 2.28538
KDM6B lysine (K)-specific demethylase 6B 2.27713
ACADVL acyl-CoA dehydrogenase, very long chain 2.27691
CRYGB crystallin, gamma B 2.27428
EPHA3 EPH receptor A3 2.27404
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 2.27383
GSTM2 glutathione S-transferase mu 2 (muscle) 2.27017
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.26909
ARSD arylsulfatase D 2.26708
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 2.26671
GRM6 glutamate receptor, metabotropic 6 2.26366
ISG20 interferon stimulated exonuclease gene 20kDa 2.25821
SQSTM1 sequestosome 1 2.25539
CRELD1 cysteine-rich with EGF-like domains 1 2.25393
KIAA1614 KIAA1614 2.25333
LOC102724428 serine/threonine-protein kinase SIK1 2.2519
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2.24899
CTSA cathepsin A 2.24484
GASK1B golgi associated kinase 1B 2.24236
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 2.24151
TSGA10 testis specific, 10 2.23696
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.23451
KIF3C kinesin family member 3C 2.23359
SLC67A1 solute carrier family 67 member 1 2.23258
ACTL8 actin-like 8 2.22419
EMILIN2 elastin microfibril interfacer 2 2.22086
TMEM127 transmembrane protein 127 2.22075
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 2.21885
CCDC186 coiled-coil domain containing 186 2.21821
DMPK dystrophia myotonica-protein kinase 2.2068
ZNF507 zinc finger protein 507 2.19958
RIPOR2 RHO family interacting cell polarization regulator 2 2.19895
LIPF lipase, gastric 2.19873
PSEN2 presenilin 2 2.19687
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 2.19662
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.18803
GPC1 glypican 1 2.18724
KRT12 keratin 12, type I 2.18655
HLA-F major histocompatibility complex, class I, F 2.18363
DCTN1 dynactin 1 2.1805
LNPEP leucyl/cystinyl aminopeptidase 2.17499
SPATA2L spermatogenesis associated 2-like 2.17488
FBXL8 F-box and leucine-rich repeat protein 8 2.16992
TMEM184B transmembrane protein 184B 2.16915
PERP PERP, TP53 apoptosis effector 2.16624
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 2.1627
PHTF1 putative homeodomain transcription factor 1 2.16028
MSX2 msh homeobox 2 2.16011
DSG2 desmoglein 2 2.1548
DNAI4 dynein axonemal intermediate chain 4 2.14889
GCLC glutamate-cysteine ligase, catalytic subunit 2.14519
JUP junction plakoglobin 2.13953
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 2.13848
KLHDC2 kelch domain containing 2 2.13193
RAB17 RAB17, member RAS oncogene family 2.13063
FBN2 fibrillin 2 2.13044
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 2.12922
FGF3 fibroblast growth factor 3 2.12661
PRAMEF13 PRAME family member 13 2.12434
H2BC21 H2B clustered histone 21 2.12086
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.11534
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.11312
PTPRJ protein tyrosine phosphatase, receptor type, J 2.11299
LZTR1 leucine-zipper-like transcription regulator 1 2.11285
CPA2 carboxypeptidase A2 (pancreatic) 2.11209
TMPRSS15 transmembrane protease, serine 15 2.1096
ANO2 anoctamin 2, calcium activated chloride channel 2.10859
F11R F11 receptor 2.10668
STIM1 stromal interaction molecule 1 2.10466
ZC2HC1C zinc finger, C2HC-type containing 1C 2.1027
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.10192
CCPG1 cell cycle progression 1 2.10164
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.10014
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 2.09842
RAB30 RAB30, member RAS oncogene family 2.09787
SH2D2A SH2 domain containing 2A 2.09211
WDTC1 WD and tetratricopeptide repeats 1 2.09071
CETN1 centrin, EF-hand protein, 1 2.08626
HHIPL2 HHIP-like 2 2.08352
PGAP3 post-GPI attachment to proteins 3 2.08253
EGLN3 egl-9 family hypoxia-inducible factor 3 2.07977
IRF9 interferon regulatory factor 9 2.07954
PGRMC1 progesterone receptor membrane component 1 2.07792
ERVMER34-1 endogenous retrovirus group MER34, member 1 2.07783
TXNL4B thioredoxin-like 4B 2.07693
ADRA2B adrenoceptor alpha 2B 2.07682
MYO1D myosin ID 2.07681
HOXB2 homeobox B2 2.07669
ADAM21 ADAM metallopeptidase domain 21 2.07613
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 2.07031
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 2.06754
HOXC13 homeobox C13 2.06354
VPS9D1 VPS9 domain containing 1 2.06352
MARCHF6 membrane associated ring-CH-type finger 6 2.06119
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 2.05922
BDKRB2 bradykinin receptor B2 2.05915
TAS2R1 taste receptor, type 2, member 1 2.05911
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 2.05782
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 2.05246
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.05211
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.05151
RAB26 RAB26, member RAS oncogene family 2.05082
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 2.04989
SNN stannin 2.0477
FSTL4 follistatin-like 4 2.04563
CST5 cystatin D 2.0456
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 2.0454
PSG5 pregnancy specific beta-1-glycoprotein 5 2.04439
PLPP2 phospholipid phosphatase 2 2.04202
TEC tec protein tyrosine kinase 2.04164
TACR2 tachykinin receptor 2 2.04163
MYL9 myosin, light chain 9, regulatory 2.04044
FHL2 four and a half LIM domains 2 2.03993
OLFML1 olfactomedin-like 1 2.03903
FAM90A1 family with sequence similarity 90, member A1 2.03848
KRTAP5-3 keratin associated protein 5-3 2.03774
WDR13 WD repeat domain 13 2.03541
MAGEA8 melanoma antigen family A8 2.0352
POF1B premature ovarian failure, 1B 2.03432
TNF tumor necrosis factor 2.03372
TRIM13 tripartite motif containing 13 2.03259
NALF1 NALCN channel auxiliary factor 1 2.03232
RFPL3 ret finger protein-like 3 2.03124
AKR1C1 aldo-keto reductase family 1, member C1 2.03114
GPR75 G protein-coupled receptor 75 2.03018
ULBP1 UL16 binding protein 1 2.0286
AUP1 ancient ubiquitous protein 1 2.02319
EFCAB6 EF-hand calcium binding domain 6 2.01554
BCORL1 BCL6 corepressor-like 1 2.01311
PRSS53 protease, serine, 53 2.01216
ADAP1 ArfGAP with dual PH domains 1 2.01118
SFRP5 secreted frizzled-related protein 5 2.00973
G6PC2 glucose-6-phosphatase, catalytic, 2 2.00901
ZFHX3 zinc finger homeobox 3 2.00713
PI3 peptidase inhibitor 3, skin-derived 2.00695
DAAM2 dishevelled associated activator of morphogenesis 2 2.00554
S100A14 S100 calcium binding protein A14 2.00367
FGF9 fibroblast growth factor 9 2.00118
RCE1 Ras converting CAAX endopeptidase 1 2.00087
CLN3 ceroid-lipofuscinosis, neuronal 3 2.00009

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -9.62311
PLK1 polo-like kinase 1 -9.22484
UBE2C ubiquitin-conjugating enzyme E2C -8.8319
KIF14 kinesin family member 14 -7.92953
KIF20A kinesin family member 20A -7.45931
PSRC1 proline/serine-rich coiled-coil 1 -7.26682
TOP2A topoisomerase (DNA) II alpha 170kDa -7.20706
CCNB2 cyclin B2 -7.14706
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -6.83911
CD320 CD320 molecule -5.73717
CCNA2 cyclin A2 -5.60446
DCK deoxycytidine kinase -5.51767
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -5.50657
CDK1 cyclin-dependent kinase 1 -5.34513
CDC45 cell division cycle 45 -5.30149
HMMR hyaluronan-mediated motility receptor (RHAMM) -4.92973
KIF15 kinesin family member 15 -4.81687
VDAC1 voltage-dependent anion channel 1 -4.80964
PCNA proliferating cell nuclear antigen -4.77933
HJURP Holliday junction recognition protein -4.72977
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.69997
FABP5 fatty acid binding protein 5 (psoriasis-associated) -4.62022
BIRC5 baculoviral IAP repeat containing 5 -4.58088
STMN1 stathmin 1 -4.55776
AURKA aurora kinase A -4.53283
HADH hydroxyacyl-CoA dehydrogenase -4.38632
KIFBP kinesin family binding protein -4.36868
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -4.23873
SLC35F2 solute carrier family 35, member F2 -4.2365
DEPDC1 DEP domain containing 1 -4.18371
KIF11 kinesin family member 11 -4.17843
KIF4A kinesin family member 4A -4.15986
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -4.11931
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -4.11814
CDCA8 cell division cycle associated 8 -4.11694
BID BH3 interacting domain death agonist -4.1133
LBR lamin B receptor -4.07938
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.07708
PARP2 poly (ADP-ribose) polymerase 2 -4.05794
C2CD5 C2 calcium-dependent domain containing 5 -3.95368
TRAP1 TNF receptor-associated protein 1 -3.92919
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.92442
SMC4 structural maintenance of chromosomes 4 -3.92373
NUP85 nucleoporin 85kDa -3.8554
EXO1 exonuclease 1 -3.85008
DSN1 DSN1, MIS12 kinetochore complex component -3.8375
CDK4 cyclin-dependent kinase 4 -3.7915
NCAPG2 non-SMC condensin II complex, subunit G2 -3.78663
VRK1 vaccinia related kinase 1 -3.752
SPAG5 sperm associated antigen 5 -3.72836
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.70259
MIS18A MIS18 kinetochore protein A -3.69518
RFWD3 ring finger and WD repeat domain 3 -3.69366
DBF4 DBF4 zinc finger -3.68632
CETN3 centrin, EF-hand protein, 3 -3.67626
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.66821
CENPA centromere protein A -3.65882
FBXO5 F-box protein 5 -3.65608
ASF1B anti-silencing function 1B histone chaperone -3.63431
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -3.62791
SHCBP1 SHC SH2-domain binding protein 1 -3.62273
PTTG1 pituitary tumor-transforming 1 -3.60179
ZDHHC6 zinc finger, DHHC-type containing 6 -3.59278
SUMF2 sulfatase modifying factor 2 -3.5508
HMGB2 high mobility group box 2 -3.54425
NEK2 NIMA-related kinase 2 -3.54147
TROAP trophinin associated protein -3.52558
EBNA1BP2 EBNA1 binding protein 2 -3.50155
SPDL1 spindle apparatus coiled-coil protein 1 -3.49953
BORA bora, aurora kinase A activator -3.46442
NDC80 NDC80 kinetochore complex component -3.44039
USP1 ubiquitin specific peptidase 1 -3.42337
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.38639
ATF5 activating transcription factor 5 -3.3841
CCNF cyclin F -3.37015
NUSAP1 nucleolar and spindle associated protein 1 -3.36535
KIF18A kinesin family member 18A -3.3587
CKAP2 cytoskeleton associated protein 2 -3.35282
TPX2 TPX2, microtubule-associated -3.34551
NEIL3 nei endonuclease VIII-like 3 (E. coli) -3.34294
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.33072
PIMREG PICALM interacting mitotic regulator -3.32039
NUP93 nucleoporin 93kDa -3.31914
KIF23 kinesin family member 23 -3.30694
SPC25 SPC25, NDC80 kinetochore complex component -3.29451
TACC3 transforming, acidic coiled-coil containing protein 3 -3.29331
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -3.29011
CENPE centromere protein E, 312kDa -3.28495
SKA1 spindle and kinetochore associated complex subunit 1 -3.27691
FIRRM FIGNL1 interacting regulator of recombination and mitosis -3.2375
CYCS cytochrome c, somatic -3.22719
SCYL3 SCY1-like 3 (S. cerevisiae) -3.20606
NCAPH non-SMC condensin I complex, subunit H -3.20187
HSPD1 heat shock 60kDa protein 1 (chaperonin) -3.18893
CDCA4 cell division cycle associated 4 -3.17029
FOXM1 forkhead box M1 -3.15906
AURKB aurora kinase B -3.10673
UBE2S ubiquitin-conjugating enzyme E2S -3.10006
OIP5 Opa interacting protein 5 -3.09887
ERCC6L excision repair cross-complementation group 6-like -3.09885
YEATS4 YEATS domain containing 4 -3.09662
TIPIN TIMELESS interacting protein -3.0905
PSIP1 PC4 and SFRS1 interacting protein 1 -3.04673
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -3.04137
RACGAP1 Rac GTPase activating protein 1 -3.02807
ATAD2 ATPase family, AAA domain containing 2 -3.01822
CDCA3 cell division cycle associated 3 -3.01724
CDC6 cell division cycle 6 -3.01515
GEMIN2 gem (nuclear organelle) associated protein 2 -2.97917
MKI67 marker of proliferation Ki-67 -2.97705
ZWILCH zwilch kinetochore protein -2.96192
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.95787
BRCA1 breast cancer 1, early onset -2.94989
ZNF83 zinc finger protein 83 -2.93304
EXOSC9 exosome component 9 -2.9317
FANCI Fanconi anemia, complementation group I -2.9211
CDC25C cell division cycle 25C -2.919
GGCT gamma-glutamylcyclotransferase -2.91024
EXOSC8 exosome component 8 -2.88049
RFC2 replication factor C (activator 1) 2, 40kDa -2.87483
TTK TTK protein kinase -2.86963
RPL39L ribosomal protein L39-like -2.8632
CDKN3 cyclin-dependent kinase inhibitor 3 -2.85951
BZW2 basic leucine zipper and W2 domains 2 -2.85013
NUP205 nucleoporin 205kDa -2.84841
RFC3 replication factor C (activator 1) 3, 38kDa -2.84605
PRPF4 pre-mRNA processing factor 4 -2.84167
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.83202
PBK PDZ binding kinase -2.81589
TRIP13 thyroid hormone receptor interactor 13 -2.79633
TEX30 testis expressed 30 -2.79439
DHFR dihydrofolate reductase -2.76018
NCAPG non-SMC condensin I complex, subunit G -2.75489
C1QBP complement component 1, q subcomponent binding protein -2.75486
ARHGAP19 Rho GTPase activating protein 19 -2.75283
OXCT1 3-oxoacid CoA transferase 1 -2.74931
RPIA ribose 5-phosphate isomerase A -2.74674
GTSE1 G-2 and S-phase expressed 1 -2.74355
TBP TATA box binding protein -2.73843
TMEM38B transmembrane protein 38B -2.73139
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.73025
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.72504
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.71067
NUP54 nucleoporin 54kDa -2.70769
HMGB1 high mobility group box 1 -2.69112
RUVBL1 RuvB-like AAA ATPase 1 -2.68601
CEP55 centrosomal protein 55kDa -2.67203
KIF18B kinesin family member 18B -2.66623
TBPL1 TBP-like 1 -2.65917
CEP76 centrosomal protein 76kDa -2.65819
METTL18 methyltransferase like 18 -2.65561
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.65422
PARPBP PARP1 binding protein -2.65249
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.64764
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.63205
BARD1 BRCA1 associated RING domain 1 -2.62915
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -2.62741
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.62566
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.62446
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.62026
CDT1 chromatin licensing and DNA replication factor 1 -2.61762
DONSON downstream neighbor of SON -2.61198
LIPT1 lipoyltransferase 1 -2.57643
PALB2 partner and localizer of BRCA2 -2.57218
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.5645
TOMM34 translocase of outer mitochondrial membrane 34 -2.55835
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -2.54847
CEP63 centrosomal protein 63kDa -2.54702
DCP2 decapping mRNA 2 -2.54091
MTERF3 mitochondrial transcription termination factor 3 -2.53058
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.52458
AK4 adenylate kinase 4 -2.50884
TRIM28 tripartite motif containing 28 -2.5059
MPHOSPH9 M-phase phosphoprotein 9 -2.50194
RBBP8 retinoblastoma binding protein 8 -2.49239
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -2.49066
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.49013
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.48689
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.48461
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) -2.48411
CASP8AP2 caspase 8 associated protein 2 -2.47902
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.47446
TTF1 transcription termination factor, RNA polymerase I -2.46974
INTS14 integrator complex subunit 14 -2.46791
PRC1 protein regulator of cytokinesis 1 -2.46017
TMPO thymopoietin -2.45843
CENPN centromere protein N -2.44679
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.43776
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.43481
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -2.4284
ZNF551 zinc finger protein 551 -2.42414
ZW10 zw10 kinetochore protein -2.42071
COASY CoA synthase -2.41645
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 -2.41558
HELLS helicase, lymphoid-specific -2.40245
LMNB1 lamin B1 -2.39851
XPO7 exportin 7 -2.39601
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -2.39141
WDHD1 WD repeat and HMG-box DNA binding protein 1 -2.38227
TRMT5 tRNA methyltransferase 5 -2.38161
CRYZ crystallin, zeta (quinone reductase) -2.37846
DCTD dCMP deaminase -2.37598
CD81 CD81 molecule -2.37406
CENPU centromere protein U -2.3725
CENPS-CORT CENPS-CORT readthrough -2.36958
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.35864
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -2.35771
RMI1 RecQ mediated genome instability 1 -2.35696
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -2.33707
RNASE7 ribonuclease, RNase A family, 7 -2.32849
ELP4 elongator acetyltransferase complex subunit 4 -2.32832
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.30863
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 -2.30768
HAT1 histone acetyltransferase 1 -2.3061
BACE2 beta-site APP-cleaving enzyme 2 -2.30494
MAT2B methionine adenosyltransferase II, beta -2.29883
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae) -2.29573
RXYLT1 ribitol xylosyltransferase 1 -2.29561
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.29449
CCNB1 cyclin B1 -2.29436
PSMC3IP PSMC3 interacting protein -2.29133
LIAS lipoic acid synthetase -2.28962
IGFBP4 insulin-like growth factor binding protein 4 -2.28733
ZMYM1 zinc finger, MYM-type 1 -2.27669
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.27354
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -2.26466
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.25916
LAP3 leucine aminopeptidase 3 -2.25815
RFC4 replication factor C (activator 1) 4, 37kDa -2.25746
LARP7 La ribonucleoprotein domain family, member 7 -2.25385
CENPC centromere protein C -2.24203
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.23566
PRMT1 protein arginine methyltransferase 1 -2.23408
SAE1 SUMO1 activating enzyme subunit 1 -2.23121
TFAM transcription factor A, mitochondrial -2.22827
KATNA1 katanin p60 (ATPase containing) subunit A 1 -2.21212
MCM10 minichromosome maintenance complex component 10 -2.20919
THYN1 thymocyte nuclear protein 1 -2.20612
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -2.20388
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.20125
FN3KRP fructosamine 3 kinase related protein -2.19764
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.19682
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.19593
CKS2 CDC28 protein kinase regulatory subunit 2 -2.19403
MED28 mediator complex subunit 28 -2.1906
RCN3 reticulocalbin 3, EF-hand calcium binding domain -2.19041
UFSP2 UFM1-specific peptidase 2 -2.18864
VBP1 von Hippel-Lindau binding protein 1 -2.1875
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -2.18606
SNUPN snurportin 1 -2.18514
ZNF274 zinc finger protein 274 -2.18088
PNRC2 proline-rich nuclear receptor coactivator 2 -2.17775
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -2.17004
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.16853
NCAPD2 non-SMC condensin I complex, subunit D2 -2.16125
MCM6 minichromosome maintenance complex component 6 -2.16062
CD58 CD58 molecule -2.14782
RPA3 replication protein A3, 14kDa -2.14058
MRPS16 mitochondrial ribosomal protein S16 -2.13721
PRPF39 pre-mRNA processing factor 39 -2.13615
TRA2B transformer 2 beta homolog (Drosophila) -2.13495
MRFAP1L1 Morf4 family associated protein 1-like 1 -2.13186
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -2.13059
HMGN1 high mobility group nucleosome binding domain 1 -2.12997
U2SURP U2 snRNP-associated SURP domain containing -2.12723
CENPF centromere protein F, 350/400kDa -2.12696
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -2.12489
NR1D2 nuclear receptor subfamily 1, group D, member 2 -2.12348
MOCS2 molybdenum cofactor synthesis 2 -2.12201
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -2.12018
ORC6 origin recognition complex, subunit 6 -2.12017
ERAP2 endoplasmic reticulum aminopeptidase 2 -2.11432
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.11345
CCDC59 coiled-coil domain containing 59 -2.11264
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.11229
FXN frataxin -2.1118
PROSER1 proline and serine rich 1 -2.10397
PARP1 poly (ADP-ribose) polymerase 1 -2.10035
ASDURF ASNSD1 upstream open reading frame -2.09676
OBI1 ORC ubiquitin ligase 1 -2.0949
RBMX2 RNA binding motif protein, X-linked 2 -2.09355
CCNE2 cyclin E2 -2.08397
MKKS McKusick-Kaufman syndrome -2.0827
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.08141
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.07478
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.07446
CCNT1 cyclin T1 -2.06641
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.06521
AP2S1 adaptor-related protein complex 2, sigma 1 subunit -2.06393
CHEK2 checkpoint kinase 2 -2.06296
DNM1L dynamin 1-like -2.05065
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.04905
DSCC1 DNA replication and sister chromatid cohesion 1 -2.04735
GPHN gephyrin -2.04524
MRPL39 mitochondrial ribosomal protein L39 -2.04489
GARRE1 granule associated Rac and RHOG effector 1 -2.03763
GPN3 GPN-loop GTPase 3 -2.03388
SEH1L SEH1-like (S. cerevisiae) -2.03317
GTPBP8 GTP-binding protein 8 (putative) -2.03138
HMGN2 high mobility group nucleosomal binding domain 2 -2.02493
RPL26L1 ribosomal protein L26-like 1 -2.01898
POLR2G polymerase (RNA) II (DNA directed) polypeptide G -2.01857
STIL SCL/TAL1 interrupting locus -2.01278
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.01094
PA2G4 proliferation-associated 2G4, 38kDa -2.01044
BUB3 BUB3 mitotic checkpoint protein -2.00903
LARS1 leucyl-tRNA synthetase 1 -2.00252
FAM111A family with sequence similarity 111, member A -2.0022
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -2.00081