CRCGN017_MCF10A.WT.HP_24H:E02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phosphonium sulfate 33.99 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:E02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 3.949
WFS1 Wolfram syndrome 1 (wolframin) 3.93319
NUCB2 nucleobindin 2 3.72618
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.17542
KLHL9 kelch-like family member 9 3.16924
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.16466
ANO1 anoctamin 1, calcium activated chloride channel 3.15151
HBB hemoglobin, beta 3.13392
TXNRD1 thioredoxin reductase 1 2.99298
ZW10 zw10 kinetochore protein 2.88406
METRN meteorin, glial cell differentiation regulator 2.80961
FKBP14 FK506 binding protein 14, 22 kDa 2.77902
HBA1 hemoglobin, alpha 1 2.7505
ACAA1 acetyl-CoA acyltransferase 1 2.55113
FGFR4 fibroblast growth factor receptor 4 2.40629
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.31176
CBR1 carbonyl reductase 1 2.26901
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.15343
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.0152

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -7.53434
PFN1 profilin 1 -4.21218
CD81 CD81 molecule -3.53962
MSMO1 methylsterol monooxygenase 1 -3.45443
MRPS2 mitochondrial ribosomal protein S2 -3.40009
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.17934
VAT1 vesicle amine transport 1 -2.92045
CANT1 calcium activated nucleotidase 1 -2.90015
RALGDS ral guanine nucleotide dissociation stimulator -2.1996
TOPBP1 topoisomerase (DNA) II binding protein 1 -2.07242
CDC20 cell division cycle 20 -2.03656
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.03113