CRCGN017_MCF10A.WT.HP_24H:E03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phosphonium sulfate 11.33 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:E03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCL2 chemokine (C-C motif) ligand 2 3.75064
STK10 serine/threonine kinase 10 3.62265
AKT1 v-akt murine thymoma viral oncogene homolog 1 3.24595
ARID5B AT rich interactive domain 5B (MRF1-like) 3.15545
NNT nicotinamide nucleotide transhydrogenase 3.07527
SNAP25 synaptosomal-associated protein, 25kDa 3.00204
CCDC92 coiled-coil domain containing 92 2.99524
ABHD4 abhydrolase domain containing 4 2.86329
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.71231
NUCB2 nucleobindin 2 2.70613
TASOR2 transcription activation suppressor family member 2 2.47447
CXCR4 chemokine (C-X-C motif) receptor 4 2.42309
HBB hemoglobin, beta 2.39486
MYBBP1A MYB binding protein (P160) 1a 2.29921
CRELD2 cysteine-rich with EGF-like domains 2 2.24147
GPR65 G protein-coupled receptor 65 2.16011
SLC68A1 solute carrier family 68 member 1 2.14576
CA3 carbonic anhydrase III 2.10322
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2.09268
RIN3 Ras and Rab interactor 3 2.08482
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 2.07364
IFNG interferon, gamma 2.06901
PODXL2 podocalyxin-like 2 2.05546
BEX2 brain expressed X-linked 2 2.04101
CYTIP cytohesin 1 interacting protein 2.01467
SRBD1 S1 RNA binding domain 1 2.00462

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -10.0
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -6.70136
INTS13 integrator complex subunit 13 -4.01194
MED21 mediator complex subunit 21 -3.81921
DERA deoxyribose-phosphate aldolase (putative) -3.7937
ERGIC2 ERGIC and golgi 2 -3.50711
CAPRIN2 caprin family member 2 -3.50563
TRAPPC3 trafficking protein particle complex 3 -3.49533
MSN moesin -3.45105
LDHB lactate dehydrogenase B -3.27631
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.18607
FASTKD5 FAST kinase domains 5 -3.10646
PRPF4 pre-mRNA processing factor 4 -3.08239
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.96945
RESF1 retroelement silencing factor 1 -2.90164
RNF167 ring finger protein 167 -2.89803
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.8806
ETNK1 ethanolamine kinase 1 -2.80045
MSMO1 methylsterol monooxygenase 1 -2.76459
BBC3 BCL2 binding component 3 -2.71669
SINHCAF SIN3-HDAC complex associated factor -2.70502
SGK1 serum/glucocorticoid regulated kinase 1 -2.64476
HMG20B high mobility group 20B -2.60252
BMAL2 basic helix-loop-helix ARNT like 2 -2.59738
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.57188
RALGDS ral guanine nucleotide dissociation stimulator -2.50014
MRPS15 mitochondrial ribosomal protein S15 -2.47693
CD44 CD44 molecule (Indian blood group) -2.46332
STK38L serine/threonine kinase 38 like -2.43768
CCDC91 coiled-coil domain containing 91 -2.41308
SRFBP1 serum response factor binding protein 1 -2.38912
FAM131A family with sequence similarity 131, member A -2.34992
CD9 CD9 molecule -2.33961
GDF15 growth differentiation factor 15 -2.33926
ARID4B AT rich interactive domain 4B (RBP1-like) -2.33172
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.2908
RLF rearranged L-myc fusion -2.27352
LAP3 leucine aminopeptidase 3 -2.2268
CLSTN3 calsyntenin 3 -2.22106
ARPC5L actin related protein 2/3 complex, subunit 5-like -2.20838
KATNA1 katanin p60 (ATPase containing) subunit A 1 -2.1964
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.1854
RHOC ras homolog family member C -2.15442
CAB39 calcium binding protein 39 -2.14212
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -2.13697
DOHH deoxyhypusine hydroxylase/monooxygenase -2.12592
CD58 CD58 molecule -2.12397
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -2.07129
RGS2 regulator of G-protein signaling 2 -2.04162
FPGS folylpolyglutamate synthase -2.04005
TM7SF3 transmembrane 7 superfamily member 3 -2.03001
RECQL RecQ helicase-like -2.01972