CRCGN017_MCF10A.WT.HP_24H:E05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone 34.5 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

204 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:E05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.66268
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.65033
TCEA2 transcription elongation factor A (SII), 2 4.02373
MVP major vault protein 3.99674
LRP10 low density lipoprotein receptor-related protein 10 3.91955
C2CD2 C2 calcium-dependent domain containing 2 3.89592
CHMP6 charged multivesicular body protein 6 3.70056
FHL2 four and a half LIM domains 2 3.54164
UBQLN2 ubiquilin 2 3.53056
MYLK myosin light chain kinase 3.47157
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.4679
CNRIP1 cannabinoid receptor interacting protein 1 3.33347
TXNRD1 thioredoxin reductase 1 3.12338
PTPN1 protein tyrosine phosphatase, non-receptor type 1 3.02901
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.01058
MGLL monoglyceride lipase 3.00532
MAP7D1 MAP7 domain containing 1 2.96494
PLK3 polo-like kinase 3 2.88182
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 2.86831
GLRX glutaredoxin (thioltransferase) 2.85002
BAG3 BCL2-associated athanogene 3 2.84796
DES desmin 2.75304
DENND2D DENN/MADD domain containing 2D 2.75208
HBB hemoglobin, beta 2.68843
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.67925
MSRA methionine sulfoxide reductase A 2.63656
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.61454
HBA1 hemoglobin, alpha 1 2.58135
MYH11 myosin, heavy chain 11, smooth muscle 2.57579
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.55679
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.5503
RPP38 ribonuclease P/MRP 38kDa subunit 2.53192
PLA2G15 phospholipase A2, group XV 2.52843
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.52456
RGS2 regulator of G-protein signaling 2 2.511
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.48536
ADGRE5 adhesion G protein-coupled receptor E5 2.47045
CNN1 calponin 1, basic, smooth muscle 2.46959
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.46181
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.42906
SAMD9 sterile alpha motif domain containing 9 2.40714
MICALL1 MICAL-like 1 2.4041
EPHA2 EPH receptor A2 2.3992
RASAL2 RAS protein activator like 2 2.35442
ZYX zyxin 2.34642
BLCAP bladder cancer associated protein 2.34593
DUSP4 dual specificity phosphatase 4 2.34152
HMOX1 heme oxygenase 1 2.33449
RIGI RNA sensor RIG-I 2.33427
LAMC2 laminin, gamma 2 2.33171
NBEAL2 neurobeachin-like 2 2.3254
CTSL cathepsin L 2.29787
ZNF185 zinc finger protein 185 (LIM domain) 2.29513
VAT1 vesicle amine transport 1 2.29342
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 2.286
NAGK N-acetylglucosamine kinase 2.27041
DUSP14 dual specificity phosphatase 14 2.2576
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 2.2555
ARFGAP1 ADP-ribosylation factor GTPase activating protein 1 2.24295
CEMIP2 cell migration inducing hyaluronidase 2 2.24135
ZMPSTE24 zinc metallopeptidase STE24 2.23651
TM4SF1 transmembrane 4 L six family member 1 2.22653
CDA cytidine deaminase 2.22544
LIPG lipase, endothelial 2.21952
DCBLD2 discoidin, CUB and LCCL domain containing 2 2.21951
MISP mitotic spindle positioning 2.18642
STAP2 signal transducing adaptor family member 2 2.17643
NRBF2 nuclear receptor binding factor 2 2.17258
ATP13A1 ATPase type 13A1 2.1589
ACAA1 acetyl-CoA acyltransferase 1 2.14913
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 2.14864
LAD1 ladinin 1 2.13135
CANT1 calcium activated nucleotidase 1 2.11866
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.1133
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.09002
CTPS1 CTP synthase 1 2.0806
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.0782
SMAGP small cell adhesion glycoprotein 2.04114
FGD6 FYVE, RhoGEF and PH domain containing 6 2.0385
GOLPH3 golgi phosphoprotein 3 (coat-protein) 2.03777
F2RL1 coagulation factor II (thrombin) receptor-like 1 2.0356
CRNN cornulin 2.03209
TICAM1 toll-like receptor adaptor molecule 1 2.02158
ULBP2 UL16 binding protein 2 2.01716
CAVIN2 caveolae associated protein 2 2.00294

decreased expression

Symbol Name Standardized Value
PSRC1 proline/serine-rich coiled-coil 1 -7.03428
TOP2A topoisomerase (DNA) II alpha 170kDa -5.78935
UBE2C ubiquitin-conjugating enzyme E2C -4.56748
NLRP4 NLR family, pyrin domain containing 4 -4.5125
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.29567
CDC45 cell division cycle 45 -4.19648
CCNB2 cyclin B2 -3.99513
AURKB aurora kinase B -3.97918
KIF14 kinesin family member 14 -3.97424
C2CD5 C2 calcium-dependent domain containing 5 -3.93699
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.8093
LBR lamin B receptor -3.80202
CETN3 centrin, EF-hand protein, 3 -3.65097
CDK1 cyclin-dependent kinase 1 -3.54059
KIF15 kinesin family member 15 -3.46631
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.43356
NCAPD2 non-SMC condensin I complex, subunit D2 -3.41416
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -3.41286
CCNA2 cyclin A2 -3.3551
NUSAP1 nucleolar and spindle associated protein 1 -3.29484
ENOPH1 enolase-phosphatase 1 -3.28106
OIP5 Opa interacting protein 5 -3.26953
HSPA8 heat shock 70kDa protein 8 -3.26033
HADH hydroxyacyl-CoA dehydrogenase -3.21614
HMGB2 high mobility group box 2 -3.18951
RNPS1 RNA binding protein S1, serine-rich domain -3.18398
PCCB propionyl CoA carboxylase, beta polypeptide -3.15269
KRT14 keratin 14, type I -3.09892
KIF4A kinesin family member 4A -3.08841
RPA3 replication protein A3, 14kDa -3.06345
KIF20A kinesin family member 20A -3.05261
KIF11 kinesin family member 11 -3.03642
CENPA centromere protein A -3.02389
DEPDC1 DEP domain containing 1 -3.02297
CDC20 cell division cycle 20 -3.02278
PLK1 polo-like kinase 1 -3.00035
AURKA aurora kinase A -2.94846
NCAPG2 non-SMC condensin II complex, subunit G2 -2.81363
SPC25 SPC25, NDC80 kinetochore complex component -2.80533
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.79992
EXO1 exonuclease 1 -2.79395
BIRC5 baculoviral IAP repeat containing 5 -2.7871
CENPE centromere protein E, 312kDa -2.78267
HMGN2 high mobility group nucleosomal binding domain 2 -2.77134
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.76616
PIMREG PICALM interacting mitotic regulator -2.74301
SUMO4 small ubiquitin-like modifier 4 -2.71547
NEIL3 nei endonuclease VIII-like 3 (E. coli) -2.71195
STMN1 stathmin 1 -2.70613
ANKRD10 ankyrin repeat domain 10 -2.68727
TK1 thymidine kinase 1, soluble -2.66683
FANCI Fanconi anemia, complementation group I -2.66329
ATF5 activating transcription factor 5 -2.61672
MXD3 MAX dimerization protein 3 -2.60599
DCK deoxycytidine kinase -2.55552
CCP110 centriolar coiled coil protein 110kDa -2.5326
DBF4 DBF4 zinc finger -2.51699
ICE2 interactor of little elongation complex ELL subunit 2 -2.50332
CDC25C cell division cycle 25C -2.49104
NDC80 NDC80 kinetochore complex component -2.48746
ACYP1 acylphosphatase 1, erythrocyte (common) type -2.46049
ATAD2 ATPase family, AAA domain containing 2 -2.45729
CCNF cyclin F -2.45594
ASF1B anti-silencing function 1B histone chaperone -2.45421
KIF18A kinesin family member 18A -2.45124
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.442
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.41376
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.38771
NCAPH non-SMC condensin I complex, subunit H -2.38757
PTTG1 pituitary tumor-transforming 1 -2.37158
YBX2 Y box binding protein 2 -2.36564
CDKN3 cyclin-dependent kinase inhibitor 3 -2.36458
EMC9 ER membrane protein complex subunit 9 -2.35187
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.34308
PARPBP PARP1 binding protein -2.32596
CD320 CD320 molecule -2.32525
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.29779
TRMT5 tRNA methyltransferase 5 -2.26357
DEK DEK proto-oncogene -2.26026
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.25894
PRCP prolylcarboxypeptidase (angiotensinase C) -2.25775
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.20661
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.20057
NEK2 NIMA-related kinase 2 -2.19917
MAT2B methionine adenosyltransferase II, beta -2.18881
DHFR dihydrofolate reductase -2.18364
FBXO5 F-box protein 5 -2.18016
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.17835
TWIST1 twist family bHLH transcription factor 1 -2.17495
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -2.16853
LOC107986346 mitochondrial import receptor subunit TOM7 homolog -2.16825
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -2.16032
RPL39L ribosomal protein L39-like -2.15809
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.15087
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.141
CKAP2 cytoskeleton associated protein 2 -2.13654
HJURP Holliday junction recognition protein -2.135
PBK PDZ binding kinase -2.11982
HAGH hydroxyacylglutathione hydrolase -2.1165
CENPS-CORT CENPS-CORT readthrough -2.09907
ZWILCH zwilch kinetochore protein -2.089
NCAPD3 non-SMC condensin II complex, subunit D3 -2.0871
SMC4 structural maintenance of chromosomes 4 -2.07893
USP1 ubiquitin specific peptidase 1 -2.07456
ERCC6L excision repair cross-complementation group 6-like -2.07117
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.06582
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.05362
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.03852
GTSE1 G-2 and S-phase expressed 1 -2.03798
METTL4 methyltransferase like 4 -2.02989
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.02787
THOC1 THO complex 1 -2.019
RFC3 replication factor C (activator 1) 3, 38kDa -2.01819
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -2.01077
TTK TTK protein kinase -2.00909
EXOSC8 exosome component 8 -2.00908
DNA2 DNA replication helicase/nuclease 2 -2.00868
KIF18B kinesin family member 18B -2.00581
ANAPC15 anaphase promoting complex subunit 15 -2.0045