CRCGN017_MCF10A.WT.HP_24H:E06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone 11.5 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:E06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 6.88694
PPARG peroxisome proliferator-activated receptor gamma 3.67995
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.49831
E2F2 E2F transcription factor 2 3.44012
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.30282
ANO1 anoctamin 1, calcium activated chloride channel 3.03141
PPP1R13B protein phosphatase 1, regulatory subunit 13B 2.97851
HBB hemoglobin, beta 2.86294
USP6NL USP6 N-terminal like 2.83533
DENND2D DENN/MADD domain containing 2D 2.53601
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.20057
ACAA1 acetyl-CoA acyltransferase 1 2.1609
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.08917
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.08765

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -4.9917
CD81 CD81 molecule -4.44411
TSPAN4 tetraspanin 4 -3.92095
GDF15 growth differentiation factor 15 -3.40576
MRPS16 mitochondrial ribosomal protein S16 -3.37064
NPDC1 neural proliferation, differentiation and control, 1 -3.23906
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.1204
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.01505
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.69501
TUBB6 tubulin, beta 6 class V -2.68774
TXNDC9 thioredoxin domain containing 9 -2.65501
SGK1 serum/glucocorticoid regulated kinase 1 -2.26901
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.26453
FBXO21 F-box protein 21 -2.20578
RALGDS ral guanine nucleotide dissociation stimulator -2.20409
PRR7 proline rich 7 (synaptic) -2.00641