CRCGN017_MCF10A.WT.HP_24H:E11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description endosulfan 33.66 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

266 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:E11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
WIF1 WNT inhibitory factor 1 5.61125
MAP7 microtubule-associated protein 7 5.48417
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.2666
AXIN1 axin 1 4.9368
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.93423
MYLK myosin light chain kinase 4.81625
STX1A syntaxin 1A (brain) 4.7846
STIMATE STIM activating enhancer 4.28145
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.90132
KDM5A lysine (K)-specific demethylase 5A 3.5581
SH2D2A SH2 domain containing 2A 3.5533
FHL2 four and a half LIM domains 2 3.4813
COL4A1 collagen, type IV, alpha 1 3.4446
VAV3 vav 3 guanine nucleotide exchange factor 3.40345
PYGL phosphorylase, glycogen, liver 3.2492
EGR1 early growth response 1 3.19217
EIF4H eukaryotic translation initiation factor 4H 3.1109
KCTD5 potassium channel tetramerization domain containing 5 2.98675
COL4A2 collagen, type IV, alpha 2 2.9845
CENPE centromere protein E, 312kDa 2.97295
HDGFL3 HDGF like 3 2.96237
ANO10 anoctamin 10 2.89175
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.88865
TPD52L2 tumor protein D52-like 2 2.81655
NRIP1 nuclear receptor interacting protein 1 2.8061
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.8042
ACAA1 acetyl-CoA acyltransferase 1 2.7919
MICALL1 MICAL-like 1 2.75397
FOSL1 FOS-like antigen 1 2.7213
PNKP polynucleotide kinase 3'-phosphatase 2.71705
VEGFC vascular endothelial growth factor C 2.706
NUCB2 nucleobindin 2 2.6953
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.6447
KIF1B kinesin family member 1B 2.62765
ASXL1 additional sex combs like transcriptional regulator 1 2.62213
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.60995
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 2.59325
DUSP2 dual specificity phosphatase 2 2.5878
DVL1 dishevelled segment polarity protein 1 2.5758
ATL2 atlastin GTPase 2 2.56085
LIF leukemia inhibitory factor 2.54255
TIAM1 T-cell lymphoma invasion and metastasis 1 2.52073
UNC13D unc-13 homolog D (C. elegans) 2.518
PEAK1 pseudopodium-enriched atypical kinase 1 2.5052
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2.50415
ADRB2 adrenoceptor beta 2, surface 2.489
PLCD1 phospholipase C, delta 1 2.44385
KIF13B kinesin family member 13B 2.4193
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.38118
CYFIP1 cytoplasmic FMR1 interacting protein 1 2.36405
ITGB5 integrin, beta 5 2.36242
LTN1 listerin E3 ubiquitin protein ligase 1 2.3391
UBE3C ubiquitin protein ligase E3C 2.323
FNDC3B fibronectin type III domain containing 3B 2.31765
CRTAM cytotoxic and regulatory T cell molecule 2.31
NUP133 nucleoporin 133kDa 2.3085
HMGA2 high mobility group AT-hook 2 2.29875
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.2966
PPT2 palmitoyl-protein thioesterase 2 2.2857
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.2717
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.27165
MED24 mediator complex subunit 24 2.2628
CASC3 cancer susceptibility candidate 3 2.2622
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 2.2602
ACTG2 actin, gamma 2, smooth muscle, enteric 2.23585
FAF1 Fas (TNFRSF6) associated factor 1 2.2192
NUP205 nucleoporin 205kDa 2.2119
SYNM synemin, intermediate filament protein 2.20265
SIRPG signal-regulatory protein gamma 2.2003
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.19055
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.18045
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 2.177
MSRA methionine sulfoxide reductase A 2.17195
LAMC1 laminin, gamma 1 (formerly LAMB2) 2.17073
PADI1 peptidyl arginine deiminase, type I 2.16985
ALX1 ALX homeobox 1 2.1546
SYNGAP1 synaptic Ras GTPase activating protein 1 2.1476
EGR3 early growth response 3 2.1395
CD34 CD34 molecule 2.1121
RAB27A RAB27A, member RAS oncogene family 2.10956
TICAM1 toll-like receptor adaptor molecule 1 2.10115
IL5 interleukin 5 2.09875
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.09655
GPATCH8 G patch domain containing 8 2.0935
CLTC clathrin, heavy chain (Hc) 2.08765
LMO1 LIM domain only 1 (rhombotin 1) 2.0846
NBAS neuroblastoma amplified sequence 2.08065
UBE2L3 ubiquitin-conjugating enzyme E2L 3 2.0724
CHIC2 cysteine-rich hydrophobic domain 2 2.0665
LTF lactotransferrin 2.0602
PRAME preferentially expressed antigen in melanoma 2.0588
TYR tyrosinase 2.0562
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.04472
HAS2 hyaluronan synthase 2 2.03585
ACOT9 acyl-CoA thioesterase 9 2.03425
BTBD3 BTB (POZ) domain containing 3 2.0308
LAIR2 leukocyte-associated immunoglobulin-like receptor 2 2.03075
IL2RB interleukin 2 receptor, beta 2.02555
PLAGL2 pleiomorphic adenoma gene-like 2 2.02492
EEF2 eukaryotic translation elongation factor 2 2.02465
IER3 immediate early response 3 2.0223
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.0093
TGM5 transglutaminase 5 2.0064

decreased expression

Symbol Name Standardized Value
DCK deoxycytidine kinase -5.4333
GDF15 growth differentiation factor 15 -4.4762
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.24038
TKT transketolase -4.12925
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.0091
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -4.0085
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -3.99965
SGK1 serum/glucocorticoid regulated kinase 1 -3.7812
FAIM Fas apoptotic inhibitory molecule -3.75075
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -3.7109
ADI1 acireductone dioxygenase 1 -3.54665
MRPL49 mitochondrial ribosomal protein L49 -3.46995
MSN moesin -3.38575
TRNAU1AP tRNA selenocysteine 1 associated protein 1 -3.3302
MSMO1 methylsterol monooxygenase 1 -3.30905
HMG20B high mobility group 20B -3.2676
CDPF1 cysteine-rich, DPF motif domain containing 1 -3.2376
BID BH3 interacting domain death agonist -3.15162
CGRRF1 cell growth regulator with ring finger domain 1 -3.1227
EXOSC4 exosome component 4 -3.03115
NKAPD1 NKAP domain containing 1 -2.9901
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 -2.98305
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) -2.93055
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.92527
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.92165
PRR15L proline rich 15-like -2.91395
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.7897
IMPACT impact RWD domain protein -2.7878
CIRBP cold inducible RNA binding protein -2.7359
MRPL11 mitochondrial ribosomal protein L11 -2.7309
NLGN4X neuroligin 4, X-linked -2.72735
ELMO3 engulfment and cell motility 3 -2.7096
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.7095
SMNDC1 survival motor neuron domain containing 1 -2.69055
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.67355
MTFR1 mitochondrial fission regulator 1 -2.6594
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.60455
UNKL unkempt family zinc finger-like -2.59085
ARL2BP ADP-ribosylation factor-like 2 binding protein -2.58725
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.5741
BBS10 Bardet-Biedl syndrome 10 -2.55475
ZNF268 zinc finger protein 268 -2.54495
SYBU syntabulin (syntaxin-interacting) -2.5094
GGPS1 geranylgeranyl diphosphate synthase 1 -2.5041
LYPD1 LY6/PLAUR domain containing 1 -2.4927
MYNN myoneurin -2.48385
RBM34 RNA binding motif protein 34 -2.47268
S100A8 S100 calcium binding protein A8 -2.47165
GP9 glycoprotein IX (platelet) -2.4699
MAP9 microtubule-associated protein 9 -2.4596
NT5DC2 5'-nucleotidase domain containing 2 -2.4465
L1TD1 LINE-1 type transposase domain containing 1 -2.4376
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa -2.4167
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -2.41465
CHMP4B charged multivesicular body protein 4B -2.41325
RNF44 ring finger protein 44 -2.4091
SCGB1D1 secretoglobin, family 1D, member 1 -2.4057
NMRK1 nicotinamide riboside kinase 1 -2.3988
TTC12 tetratricopeptide repeat domain 12 -2.3983
ZNF165 zinc finger protein 165 -2.3936
ELOVL6 ELOVL fatty acid elongase 6 -2.38573
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -2.3833
HIKESHI heat shock protein nuclear import factor hikeshi -2.3808
LY6E lymphocyte antigen 6 complex, locus E -2.37735
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14 -2.37635
TMEM184C transmembrane protein 184C -2.376
MRPL34 mitochondrial ribosomal protein L34 -2.3556
NPTX2 neuronal pentraxin II -2.3488
CD320 CD320 molecule -2.3472
MARCHF2 membrane associated ring-CH-type finger 2 -2.347
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.3448
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.3409
SERINC5 serine incorporator 5 -2.31785
LDHD lactate dehydrogenase D -2.31125
ELAC2 elaC ribonuclease Z 2 -2.3078
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -2.3022
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.3018
FAM13B family with sequence similarity 13, member B -2.29745
ECH1 enoyl CoA hydratase 1, peroxisomal -2.29735
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -2.29655
SERF1A small EDRK-rich factor 1A (telomeric) -2.2913
DCAF11 DDB1 and CUL4 associated factor 11 -2.28837
ZBTB16 zinc finger and BTB domain containing 16 -2.28275
RCOR3 REST corepressor 3 -2.2762
PARD6A par-6 family cell polarity regulator alpha -2.2714
RNASE12 ribonuclease, RNase A family, 12 (non-active) -2.26815
GPR137B G protein-coupled receptor 137B -2.2657
ASS1 argininosuccinate synthase 1 -2.25355
ADIRF adipogenesis regulatory factor -2.25015
BAD BCL2-associated agonist of cell death -2.2493
PF4 platelet factor 4 -2.2479
CAPN1 calpain 1, (mu/I) large subunit -2.2334
DCAF10 DDB1 and CUL4 associated factor 10 -2.2331
TUSC2 tumor suppressor candidate 2 -2.22918
EMC9 ER membrane protein complex subunit 9 -2.2108
RPN1 ribophorin I -2.21075
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.2083
SNCG synuclein, gamma (breast cancer-specific protein 1) -2.2037
ANKRD49 ankyrin repeat domain 49 -2.2013
RAB3A RAB3A, member RAS oncogene family -2.1979
SURF2 surfeit 2 -2.1979
RIPOR2 RHO family interacting cell polarization regulator 2 -2.19758
ABHD4 abhydrolase domain containing 4 -2.1961
SOAT2 sterol O-acyltransferase 2 -2.1924
MAGED2 melanoma antigen family D2 -2.19002
WASHC4 WASH complex subunit 4 -2.18808
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 -2.1875
NAP1L3 nucleosome assembly protein 1-like 3 -2.17185
WDR73 WD repeat domain 73 -2.1604
CYCS cytochrome c, somatic -2.158
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.1572
PPCS phosphopantothenoylcysteine synthetase -2.1558
HADH hydroxyacyl-CoA dehydrogenase -2.14408
PNPLA4 patatin-like phospholipase domain containing 4 -2.14328
RNF25 ring finger protein 25 -2.142
RWDD2A RWD domain containing 2A -2.14095
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -2.13472
AZIN1 antizyme inhibitor 1 -2.13207
RARS1 arginyl-tRNA synthetase 1 -2.12595
LEFTY1 left-right determination factor 1 -2.1233
MSLN mesothelin -2.1185
TSNAX translin-associated factor X -2.1183
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -2.11475
CLDN5 claudin 5 -2.1121
ARL17B ADP-ribosylation factor-like 17B -2.1113
VSIG10 V-set and immunoglobulin domain containing 10 -2.1082
WBP1L WW domain binding protein 1-like -2.10665
INTS8 integrator complex subunit 8 -2.1056
PMM2 phosphomannomutase 2 -2.10355
ZNF14 zinc finger protein 14 -2.10315
METTL18 methyltransferase like 18 -2.10115
SCCPDH saccharopine dehydrogenase (putative) -2.0963
LIAS lipoic acid synthetase -2.09535
ERI2 ERI1 exoribonuclease family member 2 -2.0891
OXLD1 oxidoreductase-like domain containing 1 -2.0844
TRIM68 tripartite motif containing 68 -2.0831
GID8 GID complex subunit 8 -2.08135
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.08055
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 -2.07525
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae) -2.063
CLDN7 claudin 7 -2.0597
SYNJ2BP synaptojanin 2 binding protein -2.05865
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled -2.05715
H2AC6 H2A clustered histone 6 -2.0555
MED7 mediator complex subunit 7 -2.05358
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) -2.0515
RNF170 ring finger protein 170 -2.0473
NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa -2.04365
COPS5 COP9 signalosome subunit 5 -2.0353
CAVIN2 caveolae associated protein 2 -2.0323
SPATA7 spermatogenesis associated 7 -2.0317
POU5F1 POU class 5 homeobox 1 -2.03054
STAB1 stabilin 1 -2.02255
REG1B regenerating islet-derived 1 beta -2.0199
TOB1 transducer of ERBB2, 1 -2.0161
SLC35A5 solute carrier family 35, member A5 -2.0153
INPP5K inositol polyphosphate-5-phosphatase K -2.01055
CCDC51 coiled-coil domain containing 51 -2.005
TSC22D3 TSC22 domain family, member 3 -2.00445
FBXO21 F-box protein 21 -2.00375
GMPR2 guanosine monophosphate reductase 2 -2.0032
FHL5 four and a half LIM domains 5 -2.0031
PRODH proline dehydrogenase (oxidase) 1 -2.00295