CRCGN017_MCF10A.WT.HP_24H:E12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description endosulfan 11.22 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:E12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AXIN1 axin 1 5.2339
IDE insulin-degrading enzyme 4.26853
WFS1 Wolfram syndrome 1 (wolframin) 3.75275
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.05562
DUSP6 dual specificity phosphatase 6 2.73945
TWNK twinkle mtDNA helicase 2.54225
TPD52L2 tumor protein D52-like 2 2.52535
STK10 serine/threonine kinase 10 2.52428
CHIC2 cysteine-rich hydrophobic domain 2 2.25655
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.22915
SAV1 salvador family WW domain containing protein 1 2.2032
CAB39 calcium binding protein 39 2.0642

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -7.3999
C2CD5 C2 calcium-dependent domain containing 5 -5.6055
TXNDC9 thioredoxin domain containing 9 -5.03553
PCNA proliferating cell nuclear antigen -5.0
S100A8 S100 calcium binding protein A8 -5.0
NUP85 nucleoporin 85kDa -4.86925
HAT1 histone acetyltransferase 1 -4.38575
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.32758
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.68638
LLGL2 lethal giant larvae homolog 2 (Drosophila) -3.02835
CD81 CD81 molecule -2.9745
ZNF248 zinc finger protein 248 -2.9104
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.71685
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.7116
KCTD2 potassium channel tetramerization domain containing 2 -2.6933
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.66465
AOPEP aminopeptidase O (putative) -2.6368
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.5854
INSIG1 insulin induced gene 1 -2.51392
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.3982
DHCR24 24-dehydrocholesterol reductase -2.39195
TMEM94 transmembrane protein 94 -2.3801
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -2.35377
ALDOC aldolase C, fructose-bisphosphate -2.3363
EVPL envoplakin -2.3344
KIF1A kinesin family member 1A -2.33355
ATRN attractin -2.32818
RBM4B RNA binding motif protein 4B -2.2865
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.27795
PANK2 pantothenate kinase 2 -2.2689
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -2.26265
TSPOAP1 TSPO associated protein 1 -2.2317
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase -2.2285
FDXR ferredoxin reductase -2.19735
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.18625
CDR2L cerebellar degeneration-related protein 2-like -2.18515
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) -2.17507
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.1569
BPHL biphenyl hydrolase-like (serine hydrolase) -2.13665
DHCR7 7-dehydrocholesterol reductase -2.12048
SLCO4C1 solute carrier organic anion transporter family, member 4C1 -2.1074
BAD BCL2-associated agonist of cell death -2.09577
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.08925
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) -2.05638
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) -2.0483
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.0476
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 -2.04715
FADS2 fatty acid desaturase 2 -2.044
IRAK4 interleukin-1 receptor-associated kinase 4 -2.03135
DSTN destrin (actin depolymerizing factor) -2.02378