CRCGN017_MCF10A.WT.HP_24H:E17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phos-phonium chloride 33.82 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:E17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 7.5411
MAMLD1 mastermind-like domain containing 1 5.33725
MAP7 microtubule-associated protein 7 4.46882
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.19935
EPHB2 EPH receptor B2 4.18674
TXNRD1 thioredoxin reductase 1 3.84635
AGR2 anterior gradient 2 3.7875
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 3.66978
RPP38 ribonuclease P/MRP 38kDa subunit 3.54935
MAST2 microtubule associated serine/threonine kinase 2 3.42435
COMP cartilage oligomeric matrix protein 3.14515
CBR1 carbonyl reductase 1 2.8641
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.54435
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.2936
LRP10 low density lipoprotein receptor-related protein 10 2.28735
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 2.25815
GLRX glutaredoxin (thioltransferase) 2.23673
F3 coagulation factor III (thromboplastin, tissue factor) 2.20885
PLS1 plastin 1 2.18835
SQSTM1 sequestosome 1 2.1261
TSC22D1 TSC22 domain family, member 1 2.0926
SATB1 SATB homeobox 1 2.01775

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -5.82525
PCCB propionyl CoA carboxylase, beta polypeptide -4.8957
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.6301
HMG20B high mobility group 20B -4.4756
NLRP4 NLR family, pyrin domain containing 4 -3.5544
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.3871
GDF15 growth differentiation factor 15 -2.9715
ACAA1 acetyl-CoA acyltransferase 1 -2.8696
NCAPD2 non-SMC condensin I complex, subunit D2 -2.6301
BPHL biphenyl hydrolase-like (serine hydrolase) -2.41345
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 -2.15995
ARMC7 armadillo repeat containing 7 -2.1491
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.14877
PTH1R parathyroid hormone 1 receptor -2.0495
NLRX1 NLR family member X1 -2.0477