CRCGN017_MCF10A.WT.HP_24H:E22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium (e)-4-hydroxy-3-((4-sulfonatonaphthalen-1-yl)diazenyl)naphthalene-1-sulfonate 105.18 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

27 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:E22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 4.9427
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.85505
ADAM10 ADAM metallopeptidase domain 10 4.70872
PPARG peroxisome proliferator-activated receptor gamma 4.33545
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 3.78505
MTA2 metastasis associated 1 family, member 2 3.45185
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.73255
PLS1 plastin 1 2.3528
MINDY2 MINDY lysine 48 deubiquitinase 2 2.28633
RBBP5 retinoblastoma binding protein 5 2.2745
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 2.1779
BANF1 barrier to autointegration factor 1 2.1503
NUTF2 nuclear transport factor 2 2.14205
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.12205
MDM4 MDM4, p53 regulator 2.1145
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.07708

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -5.079
MT2A metallothionein 2A -4.47845
HMG20B high mobility group 20B -4.36907
MT1X metallothionein 1X -3.00292
ACAA1 acetyl-CoA acyltransferase 1 -2.98618
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.40225
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -2.2777
CREG1 cellular repressor of E1A-stimulated genes 1 -2.21185
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) -2.1436
SEC24C SEC24 family member C -2.10725
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -2.03075