CRCGN017_MCF10A.WT.HP_24H:E24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium (e)-4-hydroxy-3-((4-sulfonatonaphthalen-1-yl)diazenyl)naphthalene-1-sulfonate 11.69 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:E24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.45485
PPARG peroxisome proliferator-activated receptor gamma 5.19495
AXIN1 axin 1 5.1394
SPAG4 sperm associated antigen 4 5.13165
STIMATE STIM activating enhancer 5.0201
GSTM2 glutathione S-transferase mu 2 (muscle) 4.87403
CCL2 chemokine (C-C motif) ligand 2 3.56215
HBB hemoglobin, beta 3.45765
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.9644
TRAPPC6A trafficking protein particle complex 6A 2.90785
SLC12A8 solute carrier family 12, member 8 2.70425
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.4738
GPER1 G protein-coupled estrogen receptor 1 2.20905
ZNF787 zinc finger protein 787 2.1497
CTSD cathepsin D 2.144
ARL4C ADP-ribosylation factor-like 4C 2.1025
DNM1 dynamin 1 2.08825
PCDHA10 protocadherin alpha 10 2.04815
METTL2A methyltransferase like 2A 2.04572
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.04285
RBL1 retinoblastoma-like 1 2.0425
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.0403
ERI3 ERI1 exoribonuclease family member 3 2.03945
ATRNL1 attractin-like 1 2.03393
FAAP100 FA core complex associated protein 100 2.02725
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 2.00895
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 2.0055
TEDC2 tubulin epsilon and delta complex 2 2.00355

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -4.94905
TSPAN4 tetraspanin 4 -4.85435
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.07245
MTERF3 mitochondrial transcription termination factor 3 -3.2098
SCYL3 SCY1-like 3 (S. cerevisiae) -3.04185
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.0293
MT2A metallothionein 2A -2.9179
RNF34 ring finger protein 34, E3 ubiquitin protein ligase -2.8321
ERGIC2 ERGIC and golgi 2 -2.81445
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.44037
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -2.29647
SNX7 sorting nexin 7 -2.2342
TLCD3A TLC domain containing 3A -2.20015
LRP10 low density lipoprotein receptor-related protein 10 -2.1535
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.1223
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -2.09585
GSTZ1 glutathione S-transferase zeta 1 -2.07185
KIFAP3 kinesin-associated protein 3 -2.06895
VAT1 vesicle amine transport 1 -2.0414
JARID2 jumonji, AT rich interactive domain 2 -2.01888