CRCGN017_MCF10A.WT.HP_24H:F01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description beta-carotene 50.99 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

610 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 9.02485
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 8.81112
TXNRD1 thioredoxin reductase 1 6.75218
GLRX glutaredoxin (thioltransferase) 6.72737
SQSTM1 sequestosome 1 6.44184
OXSR1 oxidative stress responsive 1 6.392
LRP10 low density lipoprotein receptor-related protein 10 6.38917
ABHD4 abhydrolase domain containing 4 5.84324
MVP major vault protein 5.68086
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 5.62689
RBKS ribokinase 5.05263
DENND2D DENN/MADD domain containing 2D 5.01002
AGR2 anterior gradient 2 4.88827
NUCB2 nucleobindin 2 4.73307
CTSL cathepsin L 4.71026
CLTC clathrin, heavy chain (Hc) 4.64026
CNRIP1 cannabinoid receptor interacting protein 1 4.63533
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 4.48269
DUSP14 dual specificity phosphatase 14 4.21261
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 4.16518
TNIP1 TNFAIP3 interacting protein 1 3.98356
ALAS1 5'-aminolevulinate synthase 1 3.8883
PGRMC1 progesterone receptor membrane component 1 3.84437
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.84188
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 3.80166
STX4 syntaxin 4 3.69788
SQOR sulfide quinone oxidoreductase 3.69475
WASF3 WAS protein family, member 3 3.64459
RAP1GAP RAP1 GTPase activating protein 3.63826
CDPF1 cysteine-rich, DPF motif domain containing 1 3.61917
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 3.585
HBA1 hemoglobin, alpha 1 3.43867
HSPB8 heat shock 22kDa protein 8 3.39057
VAT1 vesicle amine transport 1 3.32245
HBB hemoglobin, beta 3.32055
SCRN1 secernin 1 3.31987
TMEM50A transmembrane protein 50A 3.31262
TXNL4B thioredoxin-like 4B 3.30082
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.27646
IRS1 insulin receptor substrate 1 3.26043
MCUR1 mitochondrial calcium uniporter regulator 1 3.20318
FHL2 four and a half LIM domains 2 3.19036
MINDY1 MINDY lysine 48 deubiquitinase 1 3.12653
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.10797
ABLIM3 actin binding LIM protein family, member 3 3.08956
NIT1 nitrilase 1 3.08026
UBQLN2 ubiquilin 2 3.06951
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.06102
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.05726
DUSP4 dual specificity phosphatase 4 3.0432
WFS1 Wolfram syndrome 1 (wolframin) 3.00178
ZMPSTE24 zinc metallopeptidase STE24 2.99987
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2.95296
FOXO4 forkhead box O4 2.95129
PTPN1 protein tyrosine phosphatase, non-receptor type 1 2.92998
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.92383
F3 coagulation factor III (thromboplastin, tissue factor) 2.92236
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.87324
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.84563
IST1 increased sodium tolerance 1 homolog (yeast) 2.84347
MISP mitotic spindle positioning 2.81758
PLK3 polo-like kinase 3 2.81743
HPSE heparanase 2.80873
TIMP2 TIMP metallopeptidase inhibitor 2 2.80188
MYLK myosin light chain kinase 2.76074
UGDH UDP-glucose 6-dehydrogenase 2.75823
CAB39 calcium binding protein 39 2.75566
GPC1 glypican 1 2.72401
ACAA1 acetyl-CoA acyltransferase 1 2.72216
VLDLR very low density lipoprotein receptor 2.71315
AKR1C1 aldo-keto reductase family 1, member C1 2.70642
CTSA cathepsin A 2.69115
NCOA3 nuclear receptor coactivator 3 2.69094
ARL8B ADP-ribosylation factor-like 8B 2.6866
DYNLT3 dynein, light chain, Tctex-type 3 2.67084
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 2.64908
CEMIP2 cell migration inducing hyaluronidase 2 2.64523
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.64303
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.64209
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.64081
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 2.62936
AOX1 aldehyde oxidase 1 2.61898
GCLM glutamate-cysteine ligase, modifier subunit 2.61877
TSPAN1 tetraspanin 1 2.61858
ISG20 interferon stimulated exonuclease gene 20kDa 2.60272
CXXC1 CXXC finger protein 1 2.59669
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.58905
OSGIN1 oxidative stress induced growth inhibitor 1 2.58281
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.55005
TFE3 transcription factor binding to IGHM enhancer 3 2.5432
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.53636
TM4SF1 transmembrane 4 L six family member 1 2.52348
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.52193
C1S complement component 1, s subcomponent 2.50649
BAG3 BCL2-associated athanogene 3 2.50606
CCDC92 coiled-coil domain containing 92 2.50504
BLVRB biliverdin reductase B 2.5003
DOK7 docking protein 7 2.49157
AKR1C3 aldo-keto reductase family 1, member C3 2.48142
KRT8 keratin 8, type II 2.48059
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.47293
SMIM10L1 small integral membrane protein 10 like 1 2.44902
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 2.44861
TICAM1 toll-like receptor adaptor molecule 1 2.44611
PLS1 plastin 1 2.44521
SLC35G2 solute carrier family 35, member G2 2.44505
STXBP1 syntaxin binding protein 1 2.44142
DES desmin 2.43858
COPB1 coatomer protein complex, subunit beta 1 2.43103
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.42746
IER3 immediate early response 3 2.40333
TM9SF3 transmembrane 9 superfamily member 3 2.39123
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 2.39082
STXBP2 syntaxin binding protein 2 2.38868
RGS2 regulator of G-protein signaling 2 2.37847
RNF114 ring finger protein 114 2.37298
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 2.36646
PRDX1 peroxiredoxin 1 2.34882
SKIC2 SKI2 subunit of superkiller complex 2.34435
MYH9 myosin, heavy chain 9, non-muscle 2.31674
TMBIM1 transmembrane BAX inhibitor motif containing 1 2.31475
CMTR1 cap methyltransferase 1 2.31277
ZCCHC24 zinc finger, CCHC domain containing 24 2.30757
TMEM43 transmembrane protein 43 2.30506
CARS1 cysteinyl-tRNA synthetase 1 2.30227
CCND3 cyclin D3 2.29957
STIM1 stromal interaction molecule 1 2.29717
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.29652
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2.29572
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 2.29124
LARP6 La ribonucleoprotein domain family, member 6 2.28427
PYGB phosphorylase, glycogen; brain 2.28355
NECAP2 NECAP endocytosis associated 2 2.28245
NQO1 NAD(P)H dehydrogenase, quinone 1 2.27418
ARFIP2 ADP-ribosylation factor interacting protein 2 2.27205
KIF3C kinesin family member 3C 2.27118
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.26803
ITPKC inositol-trisphosphate 3-kinase C 2.2652
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 2.25478
MSRA methionine sulfoxide reductase A 2.25379
CASZ1 castor zinc finger 1 2.25066
KEAP1 kelch-like ECH-associated protein 1 2.24753
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2 2.24395
TCEA2 transcription elongation factor A (SII), 2 2.23969
HSPA12A heat shock 70kDa protein 12A 2.23372
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 2.22721
LEP leptin 2.22255
LAMC2 laminin, gamma 2 2.22092
RRAGA Ras-related GTP binding A 2.22084
JMJD1C jumonji domain containing 1C 2.21979
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 2.21011
TRADD TNFRSF1A-associated via death domain 2.20649
ELAC2 elaC ribonuclease Z 2 2.20457
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 2.20033
PALM2AKAP2 PALM2 and AKAP2 fusion 2.19991
CCL5 chemokine (C-C motif) ligand 5 2.19843
ITPRID2 ITPR interacting domain containing 2 2.19437
CBR1 carbonyl reductase 1 2.1938
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.19239
GPX2 glutathione peroxidase 2 2.19074
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.18539
MAN2B1 mannosidase, alpha, class 2B, member 1 2.18038
SAA2 serum amyloid A2 2.17894
EPS15 epidermal growth factor receptor pathway substrate 15 2.17858
TTC4 tetratricopeptide repeat domain 4 2.17594
CLIP1 CAP-GLY domain containing linker protein 1 2.17086
ZNHIT6 zinc finger, HIT-type containing 6 2.16169
CLDN5 claudin 5 2.16082
TGFBR3 transforming growth factor, beta receptor III 2.16071
CAVIN2 caveolae associated protein 2 2.15827
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 2.15148
FURIN furin (paired basic amino acid cleaving enzyme) 2.1509
TALDO1 transaldolase 1 2.14511
CRYGB crystallin, gamma B 2.14142
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 2.13992
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.13789
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.13722
VEGFC vascular endothelial growth factor C 2.13635
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 2.12789
APH1B APH1B gamma secretase subunit 2.12753
EFR3A EFR3 homolog A (S. cerevisiae) 2.12753
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 2.12616
CANT1 calcium activated nucleotidase 1 2.12235
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.12027
GPER1 G protein-coupled estrogen receptor 1 2.11866
MYO5A myosin VA (heavy chain 12, myoxin) 2.11715
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 2.10835
HEBP2 heme binding protein 2 2.10746
ADAM23 ADAM metallopeptidase domain 23 2.10103
RAB11FIP5 RAB11 family interacting protein 5 (class I) 2.08939
PGPEP1 pyroglutamyl-peptidase I 2.08041
LOXL1 lysyl oxidase-like 1 2.0799
VGLL3 vestigial-like family member 3 2.0785
RNLS renalase, FAD-dependent amine oxidase 2.07461
FAM114A1 family with sequence similarity 114, member A1 2.07365
PANX1 pannexin 1 2.07336
PSG2 pregnancy specific beta-1-glycoprotein 2 2.07269
BABAM2 BRISC and BRCA1 A complex member 2 2.06936
LGALS8 lectin, galactoside-binding, soluble, 8 2.06463
SOD2 superoxide dismutase 2, mitochondrial 2.06218
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.0583
EBI3 Epstein-Barr virus induced 3 2.05745
RRAS2 related RAS viral (r-ras) oncogene homolog 2 2.05728
CD79B CD79b molecule, immunoglobulin-associated beta 2.0541
NUPR1 nuclear protein, transcriptional regulator, 1 2.05369
INSL4 insulin-like 4 (placenta) 2.05115
DNM3 dynamin 3 2.0505
TMEM134 transmembrane protein 134 2.04965
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 2.04849
AVPI1 arginine vasopressin-induced 1 2.04711
PRSS8 protease, serine, 8 2.04517
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.04194
LAMB3 laminin, beta 3 2.04139
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 2.04084
RALB v-ral simian leukemia viral oncogene homolog B 2.0377
FYN FYN proto-oncogene, Src family tyrosine kinase 2.03307
FAM222B family with sequence similarity 222, member B 2.03242
FSD1 fibronectin type III and SPRY domain containing 1 2.03147
TBX21 T-box 21 2.03132
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 2.03116
ADAM17 ADAM metallopeptidase domain 17 2.02996
SLC67A1 solute carrier family 67 member 1 2.02829
PLAU plasminogen activator, urokinase 2.02649
PHKB phosphorylase kinase, beta 2.02605
S100P S100 calcium binding protein P 2.02482
DSG2 desmoglein 2 2.01732
EMC3 ER membrane protein complex subunit 3 2.01258
LOC127933115 uncharacterized LOC127933115 2.00656
EHD3 EH-domain containing 3 2.00541
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 2.00456
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 2.00453
SYT17 synaptotagmin XVII 2.00437
AMOTL2 angiomotin like 2 2.00022

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -9.02113
UBE2C ubiquitin-conjugating enzyme E2C -8.88163
KIF20A kinesin family member 20A -8.11712
PLK1 polo-like kinase 1 -8.09312
PSRC1 proline/serine-rich coiled-coil 1 -7.66216
TOP2A topoisomerase (DNA) II alpha 170kDa -6.7932
DCK deoxycytidine kinase -6.59484
CDK1 cyclin-dependent kinase 1 -6.51981
TRAP1 TNF receptor-associated protein 1 -6.05695
AURKB aurora kinase B -6.03135
CCNB2 cyclin B2 -6.00148
CCNA2 cyclin A2 -5.485
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -5.28279
NUP85 nucleoporin 85kDa -5.14586
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.05267
KIF15 kinesin family member 15 -4.96136
BIRC5 baculoviral IAP repeat containing 5 -4.95655
CD320 CD320 molecule -4.93934
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -4.92453
PRPF4 pre-mRNA processing factor 4 -4.91019
KIF11 kinesin family member 11 -4.70997
HMMR hyaluronan-mediated motility receptor (RHAMM) -4.69979
KIF4A kinesin family member 4A -4.6928
HADH hydroxyacyl-CoA dehydrogenase -4.61428
STMN1 stathmin 1 -4.50142
KIF14 kinesin family member 14 -4.49888
DSN1 DSN1, MIS12 kinetochore complex component -4.45278
C2CD5 C2 calcium-dependent domain containing 5 -4.36556
TROAP trophinin associated protein -4.34206
PCNA proliferating cell nuclear antigen -4.32289
NEK2 NIMA-related kinase 2 -4.23151
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.21188
RFC3 replication factor C (activator 1) 3, 38kDa -4.19434
GINS1 GINS complex subunit 1 (Psf1 homolog) -4.18292
AURKA aurora kinase A -4.18153
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -4.1749
NUSAP1 nucleolar and spindle associated protein 1 -4.10038
NCAPD2 non-SMC condensin I complex, subunit D2 -4.09064
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -4.05161
KRT14 keratin 14, type I -4.04892
HOXA5 homeobox A5 -3.98787
OIP5 Opa interacting protein 5 -3.97966
ASF1B anti-silencing function 1B histone chaperone -3.97883
CDCA8 cell division cycle associated 8 -3.94135
EXO1 exonuclease 1 -3.92954
DEPDC1 DEP domain containing 1 -3.91401
NCAPH non-SMC condensin I complex, subunit H -3.88676
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.86917
CENPA centromere protein A -3.85467
CKAP2 cytoskeleton associated protein 2 -3.819
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -3.81809
POLD1 polymerase (DNA directed), delta 1, catalytic subunit -3.80361
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -3.78524
PARPBP PARP1 binding protein -3.77054
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -3.75607
CCNF cyclin F -3.74846
GINS2 GINS complex subunit 2 (Psf2 homolog) -3.71705
TACC3 transforming, acidic coiled-coil containing protein 3 -3.69439
PRCP prolylcarboxypeptidase (angiotensinase C) -3.66614
VRK1 vaccinia related kinase 1 -3.6661
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -3.65899
BORA bora, aurora kinase A activator -3.65619
CETN3 centrin, EF-hand protein, 3 -3.64664
DBF4 DBF4 zinc finger -3.63412
FBXO5 F-box protein 5 -3.60223
TK1 thymidine kinase 1, soluble -3.58356
CYCS cytochrome c, somatic -3.56273
KIF18B kinesin family member 18B -3.54537
HMGB2 high mobility group box 2 -3.53318
FANCI Fanconi anemia, complementation group I -3.53241
HJURP Holliday junction recognition protein -3.5227
TMPO thymopoietin -3.49736
RACGAP1 Rac GTPase activating protein 1 -3.49108
MIS18A MIS18 kinetochore protein A -3.48159
CDCA3 cell division cycle associated 3 -3.45247
CDC45 cell division cycle 45 -3.43956
CDC25C cell division cycle 25C -3.43547
PARP2 poly (ADP-ribose) polymerase 2 -3.42448
SKA1 spindle and kinetochore associated complex subunit 1 -3.38669
CCNB1 cyclin B1 -3.38398
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -3.36826
KIF23 kinesin family member 23 -3.36323
TPX2 TPX2, microtubule-associated -3.33615
C1QBP complement component 1, q subcomponent binding protein -3.33346
NT5DC2 5'-nucleotidase domain containing 2 -3.32981
S100A8 S100 calcium binding protein A8 -3.32827
PIMREG PICALM interacting mitotic regulator -3.32685
FOXM1 forkhead box M1 -3.31651
SPC25 SPC25, NDC80 kinetochore complex component -3.30892
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -3.30812
FIRRM FIGNL1 interacting regulator of recombination and mitosis -3.28343
NCAPG2 non-SMC condensin II complex, subunit G2 -3.26234
DSCC1 DNA replication and sister chromatid cohesion 1 -3.2618
BRCA1 breast cancer 1, early onset -3.24826
MKI67 marker of proliferation Ki-67 -3.23458
NDC80 NDC80 kinetochore complex component -3.19858
EXOSC8 exosome component 8 -3.19407
PBK PDZ binding kinase -3.14768
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -3.14702
DDB2 damage-specific DNA binding protein 2, 48kDa -3.14647
FAM111A family with sequence similarity 111, member A -3.13488
SPAG5 sperm associated antigen 5 -3.11729
VDAC1 voltage-dependent anion channel 1 -3.10708
PRC1 protein regulator of cytokinesis 1 -3.08498
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.08463
ERCC6L excision repair cross-complementation group 6-like -3.07915
MCM6 minichromosome maintenance complex component 6 -3.0777
KIF18A kinesin family member 18A -3.07693
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) -3.07151
CENPE centromere protein E, 312kDa -3.06584
NEIL3 nei endonuclease VIII-like 3 (E. coli) -3.06442
MRPL11 mitochondrial ribosomal protein L11 -3.06352
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.05989
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -3.04619
LBR lamin B receptor -3.04442
SMC4 structural maintenance of chromosomes 4 -3.03515
HMGN1 high mobility group nucleosome binding domain 1 -3.03473
PPIC peptidylprolyl isomerase C (cyclophilin C) -3.03081
NLRP4 NLR family, pyrin domain containing 4 -3.02964
JMJD6 jumonji domain containing 6 -3.02666
FXN frataxin -3.02386
PSIP1 PC4 and SFRS1 interacting protein 1 -3.01177
ADI1 acireductone dioxygenase 1 -3.01166
CDT1 chromatin licensing and DNA replication factor 1 -3.01021
UBAC1 UBA domain containing 1 -3.0012
ATAD2 ATPase family, AAA domain containing 2 -3.00022
CDC6 cell division cycle 6 -2.99179
FANCG Fanconi anemia, complementation group G -2.94306
ZNF200 zinc finger protein 200 -2.929
NCAPD3 non-SMC condensin II complex, subunit D3 -2.92232
PALB2 partner and localizer of BRCA2 -2.91049
GTSE1 G-2 and S-phase expressed 1 -2.90846
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.90444
MPHOSPH9 M-phase phosphoprotein 9 -2.83371
DHFR dihydrofolate reductase -2.83157
ADNP2 ADNP homeobox 2 -2.80145
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -2.79343
RFC2 replication factor C (activator 1) 2, 40kDa -2.79044
MCM10 minichromosome maintenance complex component 10 -2.77753
CRYZ crystallin, zeta (quinone reductase) -2.77311
RFWD3 ring finger and WD repeat domain 3 -2.76544
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.76298
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.75921
TTK TTK protein kinase -2.74293
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.73703
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -2.73157
HMGB1 high mobility group box 1 -2.72202
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.71963
SPDL1 spindle apparatus coiled-coil protein 1 -2.70606
ACYP1 acylphosphatase 1, erythrocyte (common) type -2.69752
HSPD1 heat shock 60kDa protein 1 (chaperonin) -2.6877
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.68348
CKS1B CDC28 protein kinase regulatory subunit 1B -2.68249
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.67975
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.67734
OXCT1 3-oxoacid CoA transferase 1 -2.66676
DONSON downstream neighbor of SON -2.65817
INTS14 integrator complex subunit 14 -2.65039
CHAF1A chromatin assembly factor 1, subunit A (p150) -2.64424
SNRPA small nuclear ribonucleoprotein polypeptide A -2.64209
GGCT gamma-glutamylcyclotransferase -2.63936
CENPI centromere protein I -2.63478
GMNN geminin, DNA replication inhibitor -2.63126
FEN1 flap structure-specific endonuclease 1 -2.63106
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.62528
NDC1 NDC1 transmembrane nucleoporin -2.62518
HSPA8 heat shock 70kDa protein 8 -2.6193
NEMP1 nuclear envelope integral membrane protein 1 -2.61591
KNTC1 kinetochore associated 1 -2.61415
RUVBL1 RuvB-like AAA ATPase 1 -2.60973
USPL1 ubiquitin specific peptidase like 1 -2.58977
USP39 ubiquitin specific peptidase 39 -2.57753
ASPHD1 aspartate beta-hydroxylase domain containing 1 -2.57161
ARHGAP19 Rho GTPase activating protein 19 -2.54
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -2.53605
LIAS lipoic acid synthetase -2.5303
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -2.52408
LAS1L LAS1-like (S. cerevisiae) -2.52259
STOML2 stomatin (EPB72)-like 2 -2.52086
TRIP13 thyroid hormone receptor interactor 13 -2.51971
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.51832
GEMIN2 gem (nuclear organelle) associated protein 2 -2.51463
CKS2 CDC28 protein kinase regulatory subunit 2 -2.50954
IMPACT impact RWD domain protein -2.50052
RPL39L ribosomal protein L39-like -2.49944
RCN3 reticulocalbin 3, EF-hand calcium binding domain -2.49634
HIRIP3 HIRA interacting protein 3 -2.49392
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -2.48482
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -2.48448
ACOD1 aconitate decarboxylase 1 -2.48076
PYCR1 pyrroline-5-carboxylate reductase 1 -2.48011
SNRPE small nuclear ribonucleoprotein polypeptide E -2.46995
CEP55 centrosomal protein 55kDa -2.46981
HSPA1A heat shock 70kDa protein 1A -2.46582
MDC1 mediator of DNA-damage checkpoint 1 -2.46567
ZNF175 zinc finger protein 175 -2.46492
HELLS helicase, lymphoid-specific -2.4628
CENPF centromere protein F, 350/400kDa -2.46151
CPOX coproporphyrinogen oxidase -2.45678
SUMF2 sulfatase modifying factor 2 -2.45658
ERI2 ERI1 exoribonuclease family member 2 -2.44595
UXT ubiquitously-expressed, prefoldin-like chaperone -2.44376
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -2.44062
HMGN2 high mobility group nucleosomal binding domain 2 -2.44011
SESN1 sestrin 1 -2.43541
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) -2.43233
RNF138 ring finger protein 138, E3 ubiquitin protein ligase -2.42804
CDK10 cyclin-dependent kinase 10 -2.42436
FAAP100 FA core complex associated protein 100 -2.42329
ZNF322 zinc finger protein 322 -2.40681
HOXC4 homeobox C4 -2.40594
TRMT5 tRNA methyltransferase 5 -2.40495
GPS1 G protein pathway suppressor 1 -2.40091
KLHDC3 kelch domain containing 3 -2.39949
BZW2 basic leucine zipper and W2 domains 2 -2.39221
RNF38 ring finger protein 38 -2.38591
DUT deoxyuridine triphosphatase -2.3739
E2F8 E2F transcription factor 8 -2.37036
THOP1 thimet oligopeptidase 1 -2.35977
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.35438
USP19 ubiquitin specific peptidase 19 -2.35397
KIF22 kinesin family member 22 -2.35346
GPHN gephyrin -2.3533
LCMT2 leucine carboxyl methyltransferase 2 -2.3511
MED17 mediator complex subunit 17 -2.34967
BARD1 BRCA1 associated RING domain 1 -2.34841
NUP42 nucleoporin 42 -2.34303
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -2.34028
DNA2 DNA replication helicase/nuclease 2 -2.33974
ZWILCH zwilch kinetochore protein -2.33664
CDK4 cyclin-dependent kinase 4 -2.33584
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.33267
PTTG1 pituitary tumor-transforming 1 -2.33162
MSMO1 methylsterol monooxygenase 1 -2.32902
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) -2.32759
PPIH peptidylprolyl isomerase H (cyclophilin H) -2.32537
REEP4 receptor accessory protein 4 -2.32328
FTO fat mass and obesity associated -2.32222
SMC1A structural maintenance of chromosomes 1A -2.32126
PXMP4 peroxisomal membrane protein 4, 24kDa -2.3176
RMI1 RecQ mediated genome instability 1 -2.31681
GTPBP8 GTP-binding protein 8 (putative) -2.30019
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa -2.29723
MRPS7 mitochondrial ribosomal protein S7 -2.29454
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -2.28747
ZFAND1 zinc finger, AN1-type domain 1 -2.28572
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -2.28445
MCM3 minichromosome maintenance complex component 3 -2.27663
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.27527
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.27478
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.26923
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -2.26846
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.2671
MCM5 minichromosome maintenance complex component 5 -2.26211
TEDC2 tubulin epsilon and delta complex 2 -2.2562
MANEA mannosidase, endo-alpha -2.25487
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.253
GFUS GDP-L-fucose synthase -2.25114
RBMX RNA binding motif protein, X-linked -2.25024
ILF2 interleukin enhancer binding factor 2 -2.2494
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 -2.24676
CDK2 cyclin-dependent kinase 2 -2.24654
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.24638
AK8 adenylate kinase 8 -2.24388
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.24271
ZBTB5 zinc finger and BTB domain containing 5 -2.24269
TTF1 transcription termination factor, RNA polymerase I -2.24118
HAUS3 HAUS augmin-like complex, subunit 3 -2.24027
ERAP2 endoplasmic reticulum aminopeptidase 2 -2.23957
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.23865
TDP1 tyrosyl-DNA phosphodiesterase 1 -2.23642
MAT2B methionine adenosyltransferase II, beta -2.2342
EAPP E2F-associated phosphoprotein -2.2338
BRD3 bromodomain containing 3 -2.2315
TUBGCP3 tubulin, gamma complex associated protein 3 -2.23017
DCAF7 DDB1 and CUL4 associated factor 7 -2.227
ZW10 zw10 kinetochore protein -2.22322
RBM39 RNA binding motif protein 39 -2.21761
NCAPG non-SMC condensin I complex, subunit G -2.21381
UBE2S ubiquitin-conjugating enzyme E2S -2.21273
SRSF2 serine/arginine-rich splicing factor 2 -2.20991
NFYB nuclear transcription factor Y, beta -2.20602
NFIL3 nuclear factor, interleukin 3 regulated -2.20433
PLSCR1 phospholipid scramblase 1 -2.20371
ZMYM1 zinc finger, MYM-type 1 -2.20144
SLC25A40 solute carrier family 25, member 40 -2.2003
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) -2.19645
MRS2 MRS2 magnesium transporter -2.19558
POLR1E polymerase (RNA) I polypeptide E, 53kDa -2.19464
RAD54L RAD54-like (S. cerevisiae) -2.18809
PLK4 polo-like kinase 4 -2.18792
SHCBP1 SHC SH2-domain binding protein 1 -2.18627
POLM polymerase (DNA directed), mu -2.18555
TEX30 testis expressed 30 -2.18248
LMNB1 lamin B1 -2.18073
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.17997
RAB33B RAB33B, member RAS oncogene family -2.17616
MKKS McKusick-Kaufman syndrome -2.1755
TP53 tumor protein p53 -2.17498
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.17441
TMX2 thioredoxin-related transmembrane protein 2 -2.16659
MCM7 minichromosome maintenance complex component 7 -2.16617
SIGMAR1 sigma non-opioid intracellular receptor 1 -2.16424
ASCC3 activating signal cointegrator 1 complex subunit 3 -2.164
NRGN neurogranin (protein kinase C substrate, RC3) -2.16394
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) -2.16146
TIMELESS timeless circadian clock -2.15522
NUP37 nucleoporin 37kDa -2.14796
ZMYM3 zinc finger, MYM-type 3 -2.14384
HOXA4 homeobox A4 -2.13947
ZNF783 zinc finger family member 783 -2.13942
GRM2 glutamate receptor, metabotropic 2 -2.1389
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.13735
DHRS11 dehydrogenase/reductase (SDR family) member 11 -2.13509
CNOT3 CCR4-NOT transcription complex, subunit 3 -2.13375
DNAAF2 dynein, axonemal, assembly factor 2 -2.12757
DTYMK deoxythymidylate kinase (thymidylate kinase) -2.12746
TP53RK TP53 regulating kinase -2.12663
CENPX centromere protein X -2.12457
ANAPC15 anaphase promoting complex subunit 15 -2.12346
NSD2 nuclear receptor binding SET domain protein 2 -2.12262
ZDHHC6 zinc finger, DHHC-type containing 6 -2.1212
HROB homologous recombination factor with OB-fold -2.12114
YEATS4 YEATS domain containing 4 -2.12075
CENPU centromere protein U -2.12016
COQ6 coenzyme Q6 monooxygenase -2.11672
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.11654
CCNT1 cyclin T1 -2.11567
TRAPPC10 trafficking protein particle complex 10 -2.11274
MRPL12 mitochondrial ribosomal protein L12 -2.11126
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.10517
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -2.10156
ZNF551 zinc finger protein 551 -2.10096
MORC3 MORC family CW-type zinc finger 3 -2.09864
CAAP1 caspase activity and apoptosis inhibitor 1 -2.09079
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.08959
NUP93 nucleoporin 93kDa -2.08678
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.08329
CENPN centromere protein N -2.07904
COASY CoA synthase -2.07433
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.07401
FBXW2 F-box and WD repeat domain containing 2 -2.07102
ENTR1 endosome associated trafficking regulator 1 -2.07063
MXD3 MAX dimerization protein 3 -2.06866
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -2.06825
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant -2.06652
ZNF189 zinc finger protein 189 -2.06642
FRAT2 frequently rearranged in advanced T-cell lymphomas 2 -2.06614
FANCC Fanconi anemia, complementation group C -2.06543
TTI1 TELO2 interacting protein 1 -2.05965
DCAF15 DDB1 and CUL4 associated factor 15 -2.05747
NUP155 nucleoporin 155kDa -2.05584
FN3KRP fructosamine 3 kinase related protein -2.05366
BACE1 beta-site APP-cleaving enzyme 1 -2.05174
TCOF1 Treacher Collins-Franceschetti syndrome 1 -2.04606
MIS18BP1 MIS18 binding protein 1 -2.04249
PPID peptidylprolyl isomerase D -2.0399
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.03781
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.03691
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.03585
NXT1 nuclear transport factor 2-like export factor 1 -2.03298
CEP76 centrosomal protein 76kDa -2.03115
CASP8AP2 caspase 8 associated protein 2 -2.03103
ARB2A ARB2 cotranscriptional regulator A -2.03031
MED21 mediator complex subunit 21 -2.03004
CDKN3 cyclin-dependent kinase inhibitor 3 -2.02916
PRKDC protein kinase, DNA-activated, catalytic polypeptide -2.02795
ZNF227 zinc finger protein 227 -2.0269
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 -2.02272
CAPN3 calpain 3, (p94) -2.02066
TUBGCP4 tubulin, gamma complex associated protein 4 -2.02062
ZNF124 zinc finger protein 124 -2.01752
RRM1 ribonucleotide reductase M1 -2.01321
PCLAF PCNA clamp associated factor -2.01028
SH3D19 SH3 domain containing 19 -2.00493
RGS4 regulator of G-protein signaling 4 -2.00473
ELP4 elongator acetyltransferase complex subunit 4 -2.00429