CRCGN017_MCF10A.WT.HP_24H:F03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description beta-carotene 5.67 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

83 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ANO10 anoctamin 10 4.20364
UBQLN2 ubiquilin 2 4.08365
HBB hemoglobin, beta 3.7146
VGLL4 vestigial-like family member 4 3.51487
HLA-DRA major histocompatibility complex, class II, DR alpha 3.03882
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 2.65412
MBOAT2 membrane bound O-acyltransferase domain containing 2 2.52697
NGRN neugrin, neurite outgrowth associated 2.46339
ADAT1 adenosine deaminase, tRNA-specific 1 2.45987
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 2.4352
NIPAL2 NIPA-like domain containing 2 2.40839
PGLYRP4 peptidoglycan recognition protein 4 2.39813
GDF3 growth differentiation factor 3 2.33572
PARP16 poly (ADP-ribose) polymerase family, member 16 2.32495
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.32063
MEF2C myocyte enhancer factor 2C 2.31139
MMP2 matrix metallopeptidase 2 2.30364
MEN1 multiple endocrine neoplasia I 2.25464
CCP110 centriolar coiled coil protein 110kDa 2.24874
GJD2 gap junction protein, delta 2, 36kDa 2.24384
TMEM43 transmembrane protein 43 2.22687
SYT17 synaptotagmin XVII 2.2144
MAP7 microtubule-associated protein 7 2.21178
DUSP8 dual specificity phosphatase 8 2.20893
MMP9 matrix metallopeptidase 9 2.2039
DOCK3 dedicator of cytokinesis 3 2.17138
RFTN1 raftlin, lipid raft linker 1 2.13656
SIRT6 sirtuin 6 2.13408
PCNT pericentrin 2.12762
ITPKA inositol-trisphosphate 3-kinase A 2.1254
ADM adrenomedullin 2.1113
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 2.09757
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.09746
ZNF253 zinc finger protein 253 2.09617
STIMATE STIM activating enhancer 2.0901
TTLL12 tubulin tyrosine ligase-like family member 12 2.08102
CIAO3 cytosolic iron-sulfur assembly component 3 2.07295
OR2C1 olfactory receptor, family 2, subfamily C, member 1 2.06016
CD40 CD40 molecule, TNF receptor superfamily member 5 2.05993
EDN1 endothelin 1 2.04406
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.0439
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.04087
PPOX protoporphyrinogen oxidase 2.03989
DENND4B DENN/MADD domain containing 4B 2.03567
EHMT2 euchromatic histone-lysine N-methyltransferase 2 2.03539
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 2.0323
VIPR1 vasoactive intestinal peptide receptor 1 2.03187
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 2.02882
PRAMEF26 PRAME family member 26 2.02693
CACTIN cactin, spliceosome C complex subunit 2.02344
ZNF33B zinc finger protein 33B 2.01948
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 2.00128

decreased expression

Symbol Name Standardized Value
COPS7A COP9 signalosome subunit 7A -5.14972
TSPAN4 tetraspanin 4 -4.96386
KIF14 kinesin family member 14 -4.80188
SLC25A46 solute carrier family 25, member 46 -4.73477
DYNLT3 dynein, light chain, Tctex-type 3 -4.58026
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -3.93844
ANXA2 annexin A2 -3.78515
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.62371
ACAA1 acetyl-CoA acyltransferase 1 -2.55923
IFITM2 interferon induced transmembrane protein 2 -2.54655
NT5C 5', 3'-nucleotidase, cytosolic -2.53084
BASP1 brain abundant, membrane attached signal protein 1 -2.51155
TOMM34 translocase of outer mitochondrial membrane 34 -2.49867
FBXO7 F-box protein 7 -2.498
IGFBP4 insulin-like growth factor binding protein 4 -2.4337
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.39732
ARID4B AT rich interactive domain 4B (RBP1-like) -2.38618
CBR3 carbonyl reductase 3 -2.36752
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) -2.31451
PFN1 profilin 1 -2.30684
CD81 CD81 molecule -2.26376
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -2.16531
TXLNA taxilin alpha -2.14178
ANXA6 annexin A6 -2.13041
ZCCHC24 zinc finger, CCHC domain containing 24 -2.12956
CRTAP cartilage associated protein -2.08792
IFT20 intraflagellar transport 20 -2.08081
MYG1 MYG1 exonuclease -2.06476
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -2.0551
BRMS1L breast cancer metastasis-suppressor 1-like -2.05244
CD151 CD151 molecule (Raph blood group) -2.01189