CRCGN017_MCF10A.WT.HP_24H:F07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description scopolamine hydrobromide tri-hydrate 100.97 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 10.0
PPARG peroxisome proliferator-activated receptor gamma 5.58965
AGR2 anterior gradient 2 5.5795
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.36915
NANOS3 nanos homolog 3 (Drosophila) 5.0846
CXCL2 chemokine (C-X-C motif) ligand 2 4.57915
IGFBP3 insulin-like growth factor binding protein 3 4.45875
TBX2 T-box 2 4.04077
KIF5C kinesin family member 5C 3.7467
VGLL4 vestigial-like family member 4 3.45175
SMIM40 small integral membrane protein 40 2.96315
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.93745
NRBF2 nuclear receptor binding factor 2 2.76335
SEPTIN8 septin 8 2.53603
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.5206
MEX3D mex-3 RNA binding family member D 2.14165
TRPM4 transient receptor potential cation channel, subfamily M, member 4 2.1361
RESF1 retroelement silencing factor 1 2.1105
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.10055
MUS81 MUS81 structure-specific endonuclease subunit 2.055
TSPAN8 tetraspanin 8 2.04475

decreased expression

Symbol Name Standardized Value
MAPK13 mitogen-activated protein kinase 13 -5.22042
YME1L1 YME1-like 1 ATPase -4.78722
SLC35F2 solute carrier family 35, member F2 -4.7176
TEX10 testis expressed 10 -4.60595
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.5546
RPIA ribose 5-phosphate isomerase A -4.5277
PRPF4 pre-mRNA processing factor 4 -3.90177
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.88285
CPNE3 copine III -3.48345
HEATR1 HEAT repeat containing 1 -3.39878
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.34075
SH2B2 SH2B adaptor protein 2 -2.81205
HAUS2 HAUS augmin-like complex, subunit 2 -2.49445
MTPAP mitochondrial poly(A) polymerase -2.4796
TMEM14B transmembrane protein 14B -2.4724
RNF103-CHMP3 RNF103-CHMP3 readthrough -2.4706
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -2.41925
NCAPD2 non-SMC condensin I complex, subunit D2 -2.4142
CXXC4 CXXC finger protein 4 -2.4037
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) -2.39027
NECTIN2 nectin cell adhesion molecule 2 -2.37445
ABI1 abl-interactor 1 -2.35378
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.32245
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.24195
RIPOR2 RHO family interacting cell polarization regulator 2 -2.2099
CCNC cyclin C -2.2034
DND1 DND microRNA-mediated repression inhibitor 1 -2.19475
POLR1E polymerase (RNA) I polypeptide E, 53kDa -2.1926
ZNF611 zinc finger protein 611 -2.18535
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 -2.1384
DNASE2 deoxyribonuclease II, lysosomal -2.1059
SCAI suppressor of cancer cell invasion -2.1003
ORC3 origin recognition complex, subunit 3 -2.05555
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.04465
SGCE sarcoglycan, epsilon -2.04415
PELI1 pellino E3 ubiquitin protein ligase 1 -2.02825