CRCGN017_MCF10A.WT.HP_24H:F08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description scopolamine hydrobromide tri-hydrate 33.66 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

90 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.34905
C2CD2 C2 calcium-dependent domain containing 2 5.25295
HBB hemoglobin, beta 4.90295
PPARG peroxisome proliferator-activated receptor gamma 4.8585
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.7637
INTS3 integrator complex subunit 3 4.41195
HBA1 hemoglobin, alpha 1 4.40173
GATA2 GATA binding protein 2 4.00593
AXIN1 axin 1 3.94575
NNT nicotinamide nucleotide transhydrogenase 3.3314
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.95152
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 2.52235
RPL39L ribosomal protein L39-like 2.4698
POLE polymerase (DNA directed), epsilon, catalytic subunit 2.4277
PTPN3 protein tyrosine phosphatase, non-receptor type 3 2.38175
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 2.3309
ERCC3 excision repair cross-complementation group 3 2.32605
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 2.3193
PCDHGA5 protocadherin gamma subfamily A, 5 2.31525
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.307
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B 2.2576
AGPS alkylglycerone phosphate synthase 2.16765
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A 2.15805
EXOSC5 exosome component 5 2.0917
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 2.0593
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 2.0084

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -6.1728
CCNB1 cyclin B1 -5.1607
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.0568
KRT14 keratin 14, type I -5.0
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.81255
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.56693
TRAPPC3 trafficking protein particle complex 3 -4.51215
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.92782
CD81 CD81 molecule -3.91735
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.9023
JMJD6 jumonji domain containing 6 -3.6727
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.5825
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X -3.42
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -3.24755
PI3 peptidase inhibitor 3, skin-derived -3.15025
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -3.0832
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.89775
TMEM267 transmembrane protein 267 -2.74695
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 -2.73675
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.65402
S100A14 S100 calcium binding protein A14 -2.62975
SPATA2L spermatogenesis associated 2-like -2.6085
MVD mevalonate (diphospho) decarboxylase -2.5727
WASHC4 WASH complex subunit 4 -2.51073
LCN2 lipocalin 2 -2.48875
KLF10 Kruppel-like factor 10 -2.4638
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.43935
DROSHA drosha, ribonuclease type III -2.4241
ARID4B AT rich interactive domain 4B (RBP1-like) -2.3878
RFXANK regulatory factor X-associated ankyrin-containing protein -2.3799
SQLE squalene epoxidase -2.37282
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.3296
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.3279
OCEL1 occludin/ELL domain containing 1 -2.3253
CHERP calcium homeostasis endoplasmic reticulum protein -2.31577
TOR1AIP2 torsin A interacting protein 2 -2.3078
KRT33A keratin 33A, type I -2.2854
FUBP3 far upstream element (FUSE) binding protein 3 -2.2834
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -2.27295
IDI1 isopentenyl-diphosphate delta isomerase 1 -2.27065
CAPZB capping protein (actin filament) muscle Z-line, beta -2.25647
TBCA tubulin folding cofactor A -2.2521
CHI3L2 chitinase 3-like 2 -2.2487
LINC02762 long intergenic non-protein coding RNA 2762 -2.2309
H2AZ1 H2A.Z variant histone 1 -2.2246
NAMPT nicotinamide phosphoribosyltransferase -2.2216
SDCBP syndecan binding protein (syntenin) -2.2182
MXRA7 matrix-remodelling associated 7 -2.20565
HAPSTR1 HUWE1 associated protein modifying stress responses -2.19715
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -2.19515
AAMDC adipogenesis associated, Mth938 domain containing -2.17562
ACSS3 acyl-CoA synthetase short-chain family member 3 -2.168
TM4SF20 transmembrane 4 L six family member 20 -2.1677
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -2.1575
ACE2 angiotensin I converting enzyme 2 -2.13608
SAP30BP SAP30 binding protein -2.1258
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -2.10135
CCDC59 coiled-coil domain containing 59 -2.0971
GSK3B glycogen synthase kinase 3 beta -2.0726
DDA1 DET1 and DDB1 associated 1 -2.06855
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -2.06722
SQSTM1 sequestosome 1 -2.05265
SPX spexin hormone -2.04085
CSTA cystatin A (stefin A) -2.01465