CRCGN017_MCF10A.WT.HP_24H:F10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrimethamine 102.48 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

274 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCDC92 coiled-coil domain containing 92 5.18635
CARMIL1 capping protein regulator and myosin 1 linker 1 5.13135
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 4.0649
HADH hydroxyacyl-CoA dehydrogenase 3.79638
MAST2 microtubule associated serine/threonine kinase 2 3.65378
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 3.413
HBA1 hemoglobin, alpha 1 3.39549
ACAA1 acetyl-CoA acyltransferase 1 3.2422
CNRIP1 cannabinoid receptor interacting protein 1 3.17855
COQ8A coenzyme Q8A 2.9213
PNKP polynucleotide kinase 3'-phosphatase 2.89485
CCL2 chemokine (C-C motif) ligand 2 2.8521
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.84415
GAMT guanidinoacetate N-methyltransferase 2.7742
ACY1 aminoacylase 1 2.6879
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.65735
AMDHD2 amidohydrolase domain containing 2 2.6464
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 2.6368
CDPF1 cysteine-rich, DPF motif domain containing 1 2.6126
HBB hemoglobin, beta 2.61043
OLFML2B olfactomedin-like 2B 2.53485
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 2.53215
BAX BCL2-associated X protein 2.5311
INPP1 inositol polyphosphate-1-phosphatase 2.5156
RGS2 regulator of G-protein signaling 2 2.40625
SKIC2 SKI2 subunit of superkiller complex 2.3692
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.36695
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 2.36235
MCUR1 mitochondrial calcium uniporter regulator 1 2.3559
PICK1 protein interacting with PRKCA 1 2.3349
SFXN1 sideroflexin 1 2.29025
STN1 STN1 subunit of CST complex 2.2898
ATXN2 ataxin 2 2.28445
CARM1 coactivator-associated arginine methyltransferase 1 2.27615
FKBP14 FK506 binding protein 14, 22 kDa 2.2699
MRPS33 mitochondrial ribosomal protein S33 2.26125
PEX12 peroxisomal biogenesis factor 12 2.2329
NUP205 nucleoporin 205kDa 2.2295
CCNG1 cyclin G1 2.22695
QDPR quinoid dihydropteridine reductase 2.2263
B4GAT1 beta-1,4-glucuronyltransferase 1 2.1948
BACE2 beta-site APP-cleaving enzyme 2 2.18235
INF2 inverted formin, FH2 and WH2 domain containing 2.16345
DUX4 double homeobox 4 2.1615
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.15417
TBC1D16 TBC1 domain family, member 16 2.1356
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 2.13025
TNRC6B trinucleotide repeat containing 6B 2.12195
DUSP4 dual specificity phosphatase 4 2.1067
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 2.09745
MYO18A myosin XVIIIA 2.0866
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.0757
SRPX sushi-repeat containing protein, X-linked 2.05935
SNUPN snurportin 1 2.0474
PARP2 poly (ADP-ribose) polymerase 2 2.0333
CERK ceramide kinase 2.02825
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.01435
ITPRID2 ITPR interacting domain containing 2 2.00925
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.005
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 2.00305

decreased expression

Symbol Name Standardized Value
UBE2C ubiquitin-conjugating enzyme E2C -6.004
KRT14 keratin 14, type I -5.0
SGK1 serum/glucocorticoid regulated kinase 1 -5.0
PSRC1 proline/serine-rich coiled-coil 1 -4.8842
ACOT9 acyl-CoA thioesterase 9 -4.759
CHIC2 cysteine-rich hydrophobic domain 2 -4.6089
TOP2A topoisomerase (DNA) II alpha 170kDa -4.22555
CDC20 cell division cycle 20 -4.11845
TRAPPC3 trafficking protein particle complex 3 -4.11168
PMM2 phosphomannomutase 2 -3.81375
BASP1 brain abundant, membrane attached signal protein 1 -3.61155
ANKRD10 ankyrin repeat domain 10 -3.5802
NCAPD2 non-SMC condensin I complex, subunit D2 -3.49255
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -3.27907
CCNB2 cyclin B2 -3.1428
LYPLA1 lysophospholipase I -3.13718
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.1344
CDCA8 cell division cycle associated 8 -3.09525
KIF20A kinesin family member 20A -3.094
PSIP1 PC4 and SFRS1 interacting protein 1 -3.07762
ARID4B AT rich interactive domain 4B (RBP1-like) -2.9419
CHIT1 chitinase 1 (chitotriosidase) -2.93765
KIF4A kinesin family member 4A -2.91825
PLK1 polo-like kinase 1 -2.86625
FLG filaggrin -2.86305
GJD2 gap junction protein, delta 2, 36kDa -2.82645
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 -2.77225
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.69785
PHOX2A paired-like homeobox 2a -2.6551
RFPL2 ret finger protein-like 2 -2.6441
HAPSTR1 HUWE1 associated protein modifying stress responses -2.6436
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.6319
HOXD9 homeobox D9 -2.60365
PLA2G3 phospholipase A2, group III -2.59795
ZNF778 zinc finger protein 778 -2.58595
KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 -2.5829
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.5496
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.54945
LCE2B late cornified envelope 2B -2.54805
FAIM Fas apoptotic inhibitory molecule -2.53215
TMEM165 transmembrane protein 165 -2.5306
GLRA2 glycine receptor, alpha 2 -2.5248
IFT57 intraflagellar transport 57 -2.5198
NAV2 neuron navigator 2 -2.5129
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -2.4975
HOXC8 homeobox C8 -2.4909
TMSB15B thymosin beta 15B -2.48495
SMAD9 SMAD family member 9 -2.48485
NMU neuromedin U -2.48315
RNF39 ring finger protein 39 -2.4752
PRPSAP2 phosphoribosyl pyrophosphate synthetase-associated protein 2 -2.46725
PYGO1 pygopus family PHD finger 1 -2.4645
KIF11 kinesin family member 11 -2.4562
KRT2 keratin 2, type II -2.44805
BTNL2 butyrophilin-like 2 -2.4374
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 -2.4371
TET3 tet methylcytosine dioxygenase 3 -2.4303
GDF5 growth differentiation factor 5 -2.4226
GPR63 G protein-coupled receptor 63 -2.4133
CTNNA3 catenin (cadherin-associated protein), alpha 3 -2.4046
KLK2 kallikrein-related peptidase 2 -2.40422
PILRA paired immunoglobin-like type 2 receptor alpha -2.3935
SLAMF1 signaling lymphocytic activation molecule family member 1 -2.393
MSI1 musashi RNA-binding protein 1 -2.38595
RBM8A RNA binding motif protein 8A -2.38579
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -2.38285
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B -2.38165
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.37915
TLR8 toll-like receptor 8 -2.36825
LGALS14 lectin, galactoside-binding, soluble, 14 -2.3524
GPR52 G protein-coupled receptor 52 -2.35
AOC2 amine oxidase, copper containing 2 (retina-specific) -2.343
GJD3 gap junction protein, delta 3, 31.9kDa -2.33245
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 -2.3304
CLDN16 claudin 16 -2.3171
SLC39A2 solute carrier family 39 (zinc transporter), member 2 -2.3151
LUZP2 leucine zipper protein 2 -2.31175
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.30705
NOL10 nucleolar protein 10 -2.30525
IRX4 iroquois homeobox 4 -2.30225
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 -2.29655
LY6G6C lymphocyte antigen 6 complex, locus G6C -2.29555
TNF tumor necrosis factor -2.29295
HYDIN HYDIN, axonemal central pair apparatus protein -2.28535
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 -2.28175
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -2.2753
SERTAD3 SERTA domain containing 3 -2.2716
SH2D4A SH2 domain containing 4A -2.26945
IL37 interleukin 37 -2.26
BCOR BCL6 corepressor -2.2509
TRDMT1 tRNA aspartic acid methyltransferase 1 -2.247
TFDP3 transcription factor Dp family, member 3 -2.24195
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma -2.23645
AMBN ameloblastin (enamel matrix protein) -2.2338
DOK2 docking protein 2, 56kDa -2.23195
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 -2.22595
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 -2.22455
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta -2.21873
ADGRE3 adhesion G protein-coupled receptor E3 -2.21465
LORICRIN loricrin cornified envelope precursor protein -2.21385
KLHL29 kelch-like family member 29 -2.21255
BARX2 BARX homeobox 2 -2.2034
FAM13B family with sequence similarity 13, member B -2.2022
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -2.20055
CCNB1 cyclin B1 -2.20005
ADAM20 ADAM metallopeptidase domain 20 -2.1978
RFX2 regulatory factor X, 2 (influences HLA class II expression) -2.19745
ATF3 activating transcription factor 3 -2.1966
SLC61A1 solute carrier family 61 member 1 -2.1946
PKD2L1 polycystic kidney disease 2-like 1 -2.1942
WHR1 winged helix repair factor 1 -2.19413
ZNF324B zinc finger protein 324B -2.19325
CAMK1D calcium/calmodulin-dependent protein kinase ID -2.1888
INHBB inhibin, beta B -2.18445
BFSP2 beaded filament structural protein 2, phakinin -2.1839
RANBP17 RAN binding protein 17 -2.18165
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 -2.1793
RIMS1 regulating synaptic membrane exocytosis 1 -2.17775
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 -2.17585
ST7L suppression of tumorigenicity 7 like -2.16465
CRYBB2 crystallin, beta B2 -2.1623
ZC3H12A zinc finger CCCH-type containing 12A -2.16075
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -2.16002
MELTF melanotransferrin -2.15975
FAM32A family with sequence similarity 32, member A -2.15965
STX5 syntaxin 5 -2.15855
TEX11 testis expressed 11 -2.15695
PEA15 phosphoprotein enriched in astrocytes 15 -2.15315
PACC1 proton activated chloride channel 1 -2.152
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -2.1501
SIRPB1 signal-regulatory protein beta 1 -2.14858
SLC14A2 solute carrier family 14 (urea transporter), member 2 -2.1473
RENBP renin binding protein -2.1453
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic -2.1435
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) -2.1412
IL3 interleukin 3 -2.1382
GFI1B growth factor independent 1B transcription repressor -2.13665
GIMAP4 GTPase, IMAP family member 4 -2.13305
C2CD2L C2CD2-like -2.13287
GBP1 guanylate binding protein 1, interferon-inducible -2.13208
NPTX1 neuronal pentraxin I -2.13115
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.1311
LRP6 low density lipoprotein receptor-related protein 6 -2.1302
NSD3 nuclear receptor binding SET domain protein 3 -2.12963
MIMS2 mitochondrial inner membrane scaffold 2 -2.1257
FUBP1 far upstream element (FUSE) binding protein 1 -2.12529
CD83 CD83 molecule -2.1248
PHOX2B paired-like homeobox 2b -2.12305
STEEP1 STING1 ER exit protein 1 -2.1222
RFPL3 ret finger protein-like 3 -2.1197
TBXAS1 thromboxane A synthase 1 (platelet) -2.1187
EXT1 exostosin glycosyltransferase 1 -2.11457
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 -2.1088
FASN fatty acid synthase -2.10878
NOX1 NADPH oxidase 1 -2.10635
KRT37 keratin 37, type I -2.10005
PPP1R13L protein phosphatase 1, regulatory subunit 13 like -2.09995
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 -2.0956
MTNR1A melatonin receptor 1A -2.09445
ACSM1 acyl-CoA synthetase medium-chain family member 1 -2.0898
VAV1 vav 1 guanine nucleotide exchange factor -2.089
ICE1 interactor of little elongation complex ELL subunit 1 -2.0888
CTSS cathepsin S -2.0885
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 -2.0885
CSAD cysteine sulfinic acid decarboxylase -2.0857
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 -2.0815
VASP vasodilator-stimulated phosphoprotein -2.0814
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 -2.08035
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) -2.0797
MAPK10 mitogen-activated protein kinase 10 -2.07815
STRN striatin, calmodulin binding protein -2.07617
ZBTB39 zinc finger and BTB domain containing 39 -2.0747
OR1E2 olfactory receptor, family 1, subfamily E, member 2 -2.0726
COL9A1 collagen, type IX, alpha 1 -2.0674
MAP7D1 MAP7 domain containing 1 -2.06735
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) -2.06735
CDH10 cadherin 10, type 2 (T2-cadherin) -2.0666
TRPC4 transient receptor potential cation channel, subfamily C, member 4 -2.06605
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 -2.06578
RAB9A RAB9A, member RAS oncogene family -2.0646
AGO4 argonaute RISC catalytic component 4 -2.0631
WWC1 WW and C2 domain containing 1 -2.06245
NCAN neurocan -2.0621
ARL2BP ADP-ribosylation factor-like 2 binding protein -2.06175
APOBR apolipoprotein B receptor -2.05805
SYTL3 synaptotagmin-like 3 -2.0576
KRT33B keratin 33B, type I -2.05555
PRR14L proline rich 14-like -2.0511
IFNA13 interferon, alpha 13 -2.05005
FCAR Fc fragment of IgA receptor -2.04844
ETV3 ets variant 3 -2.0475
KIF14 kinesin family member 14 -2.04455
TAS2R4 taste receptor, type 2, member 4 -2.0431
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 -2.031
IFT140 intraflagellar transport 140 -2.0302
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -2.02705
PPP1R15A protein phosphatase 1, regulatory subunit 15A -2.02227
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 -2.0211
CDC25C cell division cycle 25C -2.01945
CBX2 chromobox homolog 2 -2.01685
TENT4A terminal nucleotidyltransferase 4A -2.0156
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 -2.0156
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.0136
CCDC177 coiled-coil domain containing 177 -2.01355
CLTA clathrin, light chain A -2.01285
SRF serum response factor (c-fos serum response element-binding transcription factor) -2.01137
ETF1 eukaryotic translation termination factor 1 -2.01057
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) -2.01047
JPT2 Jupiter microtubule associated homolog 2 -2.00708
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 -2.00585
GEMIN7 gem (nuclear organelle) associated protein 7 -2.0033
PPP4R3B protein phosphatase 4 regulatory subunit 3B -2.0022
HMGN4 high mobility group nucleosomal binding domain 4 -2.00118
GRM6 glutamate receptor, metabotropic 6 -2.00055