CRCGN017_MCF10A.WT.HP_24H:F11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrimethamine 34.16 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

236 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HBA1 hemoglobin, alpha 1 6.77082
AGR2 anterior gradient 2 5.91895
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 5.8939
HBB hemoglobin, beta 5.67592
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.5923
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.34555
SESN1 sestrin 1 4.3086
RGS2 regulator of G-protein signaling 2 3.7504
INPP1 inositol polyphosphate-1-phosphatase 3.4285
ACAA1 acetyl-CoA acyltransferase 1 3.28303
DDB2 damage-specific DNA binding protein 2, 48kDa 3.1252
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.9996
CDPF1 cysteine-rich, DPF motif domain containing 1 2.9097
GALE UDP-galactose-4-epimerase 2.87615
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 2.774
PNKP polynucleotide kinase 3'-phosphatase 2.7274
PCNA proliferating cell nuclear antigen 2.7138
ECD ecdysoneless homolog (Drosophila) 2.6635
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.6322
PPARG peroxisome proliferator-activated receptor gamma 2.5815
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.5713
KRT18 keratin 18, type I 2.51445
SKIC2 SKI2 subunit of superkiller complex 2.47205
AMDHD2 amidohydrolase domain containing 2 2.46075
PROCR protein C receptor, endothelial 2.44995
GTF2IRD1 GTF2I repeat domain containing 1 2.43275
CBR1 carbonyl reductase 1 2.3855
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 2.37185
FDXR ferredoxin reductase 2.34655
EIF3D eukaryotic translation initiation factor 3, subunit D 2.3275
THYN1 thymocyte nuclear protein 1 2.32005
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 2.30375
CYBA cytochrome b-245, alpha polypeptide 2.292
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.28215
TBC1D10C TBC1 domain family, member 10C 2.277
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.27225
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.25125
KYAT1 kynurenine aminotransferase 1 2.2418
MRPL16 mitochondrial ribosomal protein L16 2.2189
HDAC3 histone deacetylase 3 2.21775
EPHA2 EPH receptor A2 2.2079
TYK2 tyrosine kinase 2 2.1835
RCC1L RCC1 like 2.18225
SPAG7 sperm associated antigen 7 2.1713
FN3KRP fructosamine 3 kinase related protein 2.1529
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 2.1274
CCNG1 cyclin G1 2.12635
FKBP3 FK506 binding protein 3, 25kDa 2.11915
RABGGTA Rab geranylgeranyltransferase, alpha subunit 2.1137
TRAPPC12 trafficking protein particle complex 12 2.1105
ARAF A-Raf proto-oncogene, serine/threonine kinase 2.1093
MRPS16 mitochondrial ribosomal protein S16 2.1051
RWDD1 RWD domain containing 1 2.10415
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 2.09695
ASL argininosuccinate lyase 2.0955
MPST mercaptopyruvate sulfurtransferase 2.0944
XPC xeroderma pigmentosum, complementation group C 2.0776
ALDOC aldolase C, fructose-bisphosphate 2.0714
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.0706
PARP2 poly (ADP-ribose) polymerase 2 2.06923
CDC45 cell division cycle 45 2.06005
COPS6 COP9 signalosome subunit 6 2.05675
ASCC2 activating signal cointegrator 1 complex subunit 2 2.05525
PRAF2 PRA1 domain family, member 2 2.05355
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 2.05175
TFB1M transcription factor B1, mitochondrial 2.0396
FUCA1 fucosidase, alpha-L- 1, tissue 2.0355
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 2.0348
RFC2 replication factor C (activator 1) 2, 40kDa 2.0322
ECI2 enoyl-CoA delta isomerase 2 2.02205
MAGED1 melanoma antigen family D1 2.0141
HSPA4L heat shock 70kDa protein 4-like 2.01095
TEX264 testis expressed 264 2.0097
HMGN3 high mobility group nucleosomal binding domain 3 2.00725
JMJD7 jumonji domain containing 7 2.00475

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -6.4559
CDC20 cell division cycle 20 -5.5706
PSRC1 proline/serine-rich coiled-coil 1 -5.2795
PGAM4 phosphoglycerate mutase family member 4 -4.9024
CRK v-crk avian sarcoma virus CT10 oncogene homolog -4.8395
UBE2C ubiquitin-conjugating enzyme E2C -4.7347
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.26235
ITFG1 integrin alpha FG-GAP repeat containing 1 -4.244
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.2206
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -4.0257
MSN moesin -4.01775
KIF20A kinesin family member 20A -3.78245
PLK1 polo-like kinase 1 -3.7446
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.6956
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.61698
TOP2A topoisomerase (DNA) II alpha 170kDa -3.60822
AURKA aurora kinase A -3.49458
MSMO1 methylsterol monooxygenase 1 -3.36215
DIPK1A divergent protein kinase domain 1A -3.32812
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -3.17145
CCNB1 cyclin B1 -3.1293
RBM12B RNA binding motif protein 12B -2.94655
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -2.91575
CDCA8 cell division cycle associated 8 -2.8838
CILK1 ciliogenesis associated kinase 1 -2.8513
KIF4A kinesin family member 4A -2.8365
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) -2.77525
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 -2.7439
PTPRG protein tyrosine phosphatase, receptor type, G -2.7123
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.7094
SPRED2 sprouty-related, EVH1 domain containing 2 -2.70692
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.6979
PFN1 profilin 1 -2.6676
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10 -2.63995
MT1X metallothionein 1X -2.62033
KIF14 kinesin family member 14 -2.60615
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 -2.6035
EXT1 exostosin glycosyltransferase 1 -2.60022
VEZT vezatin, adherens junctions transmembrane protein -2.57825
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.54557
CCL23 chemokine (C-C motif) ligand 23 -2.53553
KCNIP2 Kv channel interacting protein 2 -2.5234
KIF11 kinesin family member 11 -2.51785
CER1 cerberus 1, DAN family BMP antagonist -2.5146
CSRNP2 cysteine-serine-rich nuclear protein 2 -2.49775
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.4737
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) -2.46945
MT2A metallothionein 2A -2.4652
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.4467
NRF1 nuclear respiratory factor 1 -2.43773
PRKCG protein kinase C, gamma -2.437
KCNK5 potassium channel, two pore domain subfamily K, member 5 -2.4316
BCORL1 BCL6 corepressor-like 1 -2.41105
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.40935
ZNF518A zinc finger protein 518A -2.40815
ADGRL1 adhesion G protein-coupled receptor L1 -2.40758
NTF3 neurotrophin 3 -2.4027
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1 -2.40255
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 -2.3934
NOX1 NADPH oxidase 1 -2.38601
ATRNL1 attractin-like 1 -2.37932
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) -2.3708
FOXD2 forkhead box D2 -2.36435
LBR lamin B receptor -2.36295
POU3F3 POU class 3 homeobox 3 -2.36205
WASHC4 WASH complex subunit 4 -2.36007
PCDH8 protocadherin 8 -2.35955
USB1 U6 snRNA biogenesis 1 -2.35305
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type -2.35279
RAB33A RAB33A, member RAS oncogene family -2.3485
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) -2.3466
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.34515
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -2.3316
GAP43 growth associated protein 43 -2.322
CDC42 cell division cycle 42 -2.31422
MEGF8 multiple EGF-like-domains 8 -2.2884
GAN gigaxonin -2.28515
QRICH1 glutamine-rich 1 -2.2821
FXYD7 FXYD domain containing ion transport regulator 7 -2.27685
KLHDC8A kelch domain containing 8A -2.274
ZNF778 zinc finger protein 778 -2.27295
FERMT2 fermitin family member 2 -2.27063
NRIP2 nuclear receptor interacting protein 2 -2.26045
CDX2 caudal type homeobox 2 -2.2601
NOPCHAP1 NOP protein chaperone 1 -2.25705
CNN3 calponin 3, acidic -2.25605
CRX cone-rod homeobox -2.2429
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -2.23855
NRDE2 NRDE-2, necessary for RNA interference, domain containing -2.23405
TET3 tet methylcytosine dioxygenase 3 -2.23385
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 -2.23035
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -2.22135
HTD2 hydroxyacyl-thioester dehydratase type 2 -2.20825
PHF24 PHD finger protein 24 -2.20598
BRSK2 BR serine/threonine kinase 2 -2.19975
NCAPD2 non-SMC condensin I complex, subunit D2 -2.19515
CEP55 centrosomal protein 55kDa -2.1913
OGFOD1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 -2.19075
ANKRD10 ankyrin repeat domain 10 -2.18765
ZNF573 zinc finger protein 573 -2.18505
CENPE centromere protein E, 312kDa -2.17325
TRPC4 transient receptor potential cation channel, subfamily C, member 4 -2.16762
BBS10 Bardet-Biedl syndrome 10 -2.166
AZIN1 antizyme inhibitor 1 -2.1657
TMEM127 transmembrane protein 127 -2.16015
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) -2.15815
IL3 interleukin 3 -2.1576
BTBD8 BTB (POZ) domain containing 8 -2.15585
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 -2.1536
SATB2 SATB homeobox 2 -2.14957
DBF4B DBF4 zinc finger B -2.14825
ABHD18 abhydrolase domain containing 18 -2.14805
NUSAP1 nucleolar and spindle associated protein 1 -2.14615
ARID4B AT rich interactive domain 4B (RBP1-like) -2.1428
ARHGAP11A Rho GTPase activating protein 11A -2.14195
MAPK4 mitogen-activated protein kinase 4 -2.13975
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 -2.13048
NHLH1 nescient helix loop helix 1 -2.12905
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion -2.12785
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2 -2.1269
PTCH2 patched 2 -2.1246
LRP6 low density lipoprotein receptor-related protein 6 -2.12393
NOL10 nucleolar protein 10 -2.11925
EXTL1 exostosin-like glycosyltransferase 1 -2.1157
CNKSR3 CNKSR family member 3 -2.1094
BRWD1 bromodomain and WD repeat domain containing 1 -2.10877
CSAD cysteine sulfinic acid decarboxylase -2.1025
METTL4 methyltransferase like 4 -2.09435
PGK1 phosphoglycerate kinase 1 -2.09242
APOA1 apolipoprotein A-I -2.09173
FJX1 four jointed box 1 (Drosophila) -2.0895
FRZB frizzled-related protein -2.08768
ANXA2 annexin A2 -2.0876
NANOS2 nanos homolog 2 (Drosophila) -2.0875
KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 -2.0847
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa -2.07928
UBTD1 ubiquitin domain containing 1 -2.06165
MMP9 matrix metallopeptidase 9 -2.0614
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 -2.0602
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -2.05658
H2BC6 H2B clustered histone 6 -2.0476
E2F5 E2F transcription factor 5, p130-binding -2.04475
THY1 Thy-1 cell surface antigen -2.04437
SRF serum response factor (c-fos serum response element-binding transcription factor) -2.04058
INSIG1 insulin induced gene 1 -2.0396
NLK nemo-like kinase -2.03775
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa -2.0368
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) -2.0365
ANKRD55 ankyrin repeat domain 55 -2.03495
DENND5B DENN/MADD domain containing 5B -2.0321
EGR4 early growth response 4 -2.02872
SPMAP2 sperm microtubule associated protein 2 -2.0285
SHISAL1 shisa like 1 -2.02698
SPATA1 spermatogenesis associated 1 -2.02685
PCDHGA1 protocadherin gamma subfamily A, 1 -2.0238
EXO5 exonuclease 5 -2.01945
EHD4 EH-domain containing 4 -2.0166
GPR25 G protein-coupled receptor 25 -2.01335
STRN3 striatin, calmodulin binding protein 3 -2.01003
FLNA filamin A, alpha -2.0047
CD300C CD300c molecule -2.00135