| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | pyrimethamine 11.39 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome) |
| Similar Terms | |
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51 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPAG4 | sperm associated antigen 4 | 5.78385 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 5.7009 |
| E2F2 | E2F transcription factor 2 | 5.65975 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 5.14825 |
| AGR2 | anterior gradient 2 | 4.9279 |
| ST3GAL5 | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | 4.52305 |
| GATA3 | GATA binding protein 3 | 4.20973 |
| BID | BH3 interacting domain death agonist | 3.39142 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.27205 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 3.10625 |
| ALDOC | aldolase C, fructose-bisphosphate | 2.98145 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 2.83055 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 2.73298 |
| GNA15 | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | 2.336 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 2.3311 |
| EIF3D | eukaryotic translation initiation factor 3, subunit D | 2.3153 |
| NFIL3 | nuclear factor, interleukin 3 regulated | 2.3101 |
| ECSIT | ECSIT signalling integrator | 2.23215 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 2.19893 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 2.1226 |
| SEPTIN9 | septin 9 | 2.09655 |
| STN1 | STN1 subunit of CST complex | 2.0712 |
| GNPAT | glyceronephosphate O-acyltransferase | 2.0625 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 2.05258 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 2.0454 |
| SPAG7 | sperm associated antigen 7 | 2.0333 |
| DHPS | deoxyhypusine synthase | 2.02973 |
| VTA1 | vesicle (multivesicular body) trafficking 1 | 2.00815 |
| NMD3 | NMD3 ribosome export adaptor | 2.00195 |
| Symbol | Name | Standardized Value |
|---|---|---|
| BAG3 | BCL2-associated athanogene 3 | -5.71385 |
| HAT1 | histone acetyltransferase 1 | -5.27805 |
| TUBB6 | tubulin, beta 6 class V | -4.81685 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -4.49075 |
| DSG2 | desmoglein 2 | -4.4713 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -3.2026 |
| NANOS3 | nanos homolog 3 (Drosophila) | -3.04485 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.69205 |
| ECHDC3 | enoyl CoA hydratase domain containing 3 | -2.53205 |
| IRF1 | interferon regulatory factor 1 | -2.4235 |
| SMNDC1 | survival motor neuron domain containing 1 | -2.3649 |
| CORO1A | coronin, actin binding protein, 1A | -2.2874 |
| ZFTA | zinc finger translocation associated | -2.212 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -2.16525 |
| PLA2G12A | phospholipase A2, group XIIA | -2.1604 |
| CTBP2 | C-terminal binding protein 2 | -2.11685 |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) | -2.09475 |
| RMC1 | regulator of MON1-CCZ1 | -2.08115 |
| PWWP3A | PWWP domain containing 3A, DNA repair factor | -2.07775 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -2.0638 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | -2.0378 |
| DMWD | dystrophia myotonica, WD repeat containing | -2.0151 |
