CRCGN017_MCF10A.WT.HP_24H:F13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description l-ascorbic acid 100.97 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 5.04358
MNAT1 MNAT CDK-activating kinase assembly factor 1 5.0134
CCP110 centriolar coiled coil protein 110kDa 4.9829
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.85075
EPHB2 EPH receptor B2 4.7857
ABHD4 abhydrolase domain containing 4 4.4102
WIF1 WNT inhibitory factor 1 4.03295
TBX2 T-box 2 4.00663
VGLL4 vestigial-like family member 4 3.30875
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 2.89495
TBXA2R thromboxane A2 receptor 2.65379
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.5677
NSG2 neuronal vesicle trafficking associated 2 2.51635
SATB1 SATB homeobox 1 2.48585
SNAP91 synaptosomal-associated protein, 91kDa 2.3141
CNRIP1 cannabinoid receptor interacting protein 1 2.1342
NCKAP1 NCK-associated protein 1 2.1195
CTNNA2 catenin (cadherin-associated protein), alpha 2 2.0624
CYFIP1 cytoplasmic FMR1 interacting protein 1 2.02305

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -5.0
KRT14 keratin 14, type I -5.0
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.99595
MRPS2 mitochondrial ribosomal protein S2 -4.71755
SGK1 serum/glucocorticoid regulated kinase 1 -4.14405
CHMP4B charged multivesicular body protein 4B -3.92777
ETFB electron-transfer-flavoprotein, beta polypeptide -3.82995
OXA1L oxidase (cytochrome c) assembly 1-like -3.8193
PAEP progestagen-associated endometrial protein -3.09575
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.08285
EIF5 eukaryotic translation initiation factor 5 -3.05555
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.89455
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.75155
SNX7 sorting nexin 7 -2.55945
PDZK1IP1 PDZK1 interacting protein 1 -2.3426
PFN1 profilin 1 -2.3334
WASHC4 WASH complex subunit 4 -2.32942
CYB5R2 cytochrome b5 reductase 2 -2.3173
REC8 REC8 meiotic recombination protein -2.28815
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 -2.25615
MED22 mediator complex subunit 22 -2.21085
PLAAT3 phospholipase A and acyltransferase 3 -2.1827
SIRT1 sirtuin 1 -2.15135
DPP4 dipeptidyl-peptidase 4 -2.08997
VAMP8 vesicle-associated membrane protein 8 -2.06345
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.04845
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.04462
NVL nuclear VCP-like -2.04035
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.03355
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -2.01075