CRCGN017_MCF10A.WT.HP_24H:F14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description l-ascorbic acid 33.66 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZW10 zw10 kinetochore protein 10.0
ABHD4 abhydrolase domain containing 4 6.42415
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.34905
PPARG peroxisome proliferator-activated receptor gamma 5.2081
ADGRE5 adhesion G protein-coupled receptor E5 4.95795
TBX2 T-box 2 4.57385
NOSIP nitric oxide synthase interacting protein 3.0723
HBB hemoglobin, beta 2.88898
CNRIP1 cannabinoid receptor interacting protein 1 2.50745
SKIC8 SKI8 subunit of superkiller complex 2.4825
WIF1 WNT inhibitory factor 1 2.3083
RAB31 RAB31, member RAS oncogene family 2.27313
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.26075
CEP76 centrosomal protein 76kDa 2.17105
RBM7 RNA binding motif protein 7 2.07485
CBR1 carbonyl reductase 1 2.0649
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.0476
PDIA5 protein disulfide isomerase family A, member 5 2.0141
HBA1 hemoglobin, alpha 1 2.00297

decreased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 -6.39645
SLC35F2 solute carrier family 35, member F2 -5.0773
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.0061
ACOT9 acyl-CoA thioesterase 9 -4.68675
CHMP4B charged multivesicular body protein 4B -4.5688
KRT14 keratin 14, type I -4.4233
MRPS2 mitochondrial ribosomal protein S2 -4.30185
PFN1 profilin 1 -3.4328
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -3.3889
PAEP progestagen-associated endometrial protein -3.0602
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.78487
ANXA2 annexin A2 -2.74105
NCBP3 nuclear cap binding subunit 3 -2.68865
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.58755
WASHC4 WASH complex subunit 4 -2.50887
REEP5 receptor accessory protein 5 -2.41278
ORAI2 ORAI calcium release-activated calcium modulator 2 -2.37838
PIERCE1 piercer of microtubule wall 1 -2.21525
CDHR2 cadherin-related family member 2 -2.15165
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -2.10915
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 -2.07015
MT2A metallothionein 2A -2.0609
PLEKHS1 pleckstrin homology domain containing, family S member 1 -2.05405
GPR17 G protein-coupled receptor 17 -2.0405
TMEM268 transmembrane protein 268 -2.03365
TIMCC TIM double twin CX3C motif chaperone -2.03165
KRT86 keratin 86, type II -2.0287
ARHGAP9 Rho GTPase activating protein 9 -2.01745
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein -2.0137
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -2.00775
FBXL2 F-box and leucine-rich repeat protein 2 -2.0025