CRCGN017_MCF10A.WT.HP_24H:F15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description l-ascorbic acid 11.22 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

120 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LAGE3 L antigen family, member 3 4.96055
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 4.7925
ZNF318 zinc finger protein 318 4.65092
ZW10 zw10 kinetochore protein 4.51835
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.3963
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.12295
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.0146
HBA1 hemoglobin, alpha 1 3.70543
DENND2D DENN/MADD domain containing 2D 3.6797
HBB hemoglobin, beta 3.52183
CGRRF1 cell growth regulator with ring finger domain 1 3.1303
TBX2 T-box 2 3.07465
GPATCH8 G patch domain containing 8 2.93633
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.88625
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 2.6631
CCDC6 coiled-coil domain containing 6 2.636
PALB2 partner and localizer of BRCA2 2.62795
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa 2.5837
KIF3A kinesin family member 3A 2.5052
SAP30BP SAP30 binding protein 2.43935
F3 coagulation factor III (thromboplastin, tissue factor) 2.40385
OTUD3 OTU deubiquitinase 3 2.39945
BMS1 BMS1 ribosome biogenesis factor 2.3526
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 2.298
EXD2 exonuclease 3'-5' domain containing 2 2.25525
NUP155 nucleoporin 155kDa 2.2409
FAF2 Fas associated factor family member 2 2.23315
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.2308
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 2.218
SIPA1 signal-induced proliferation-associated 1 2.20235
SART1 squamous cell carcinoma antigen recognized by T cells 2.1993
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.17985
KDM1A lysine (K)-specific demethylase 1A 2.16595
CAPN7 calpain 7 2.15885
SMAD5 SMAD family member 5 2.1546
CSNK1A1 casein kinase 1, alpha 1 2.14546
NUP205 nucleoporin 205kDa 2.1222
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2.10748
APIP APAF1 interacting protein 2.1047
GRHL2 grainyhead-like 2 (Drosophila) 2.1018
NSD1 nuclear receptor binding SET domain protein 1 2.1017
PDGFC platelet derived growth factor C 2.096
WASF1 WAS protein family, member 1 2.09445
DEPDC1 DEP domain containing 1 2.0599
CEPT1 choline/ethanolamine phosphotransferase 1 2.0511
MCOLN3 mucolipin 3 2.05
TRIP6 thyroid hormone receptor interactor 6 2.04365
HSPA4L heat shock 70kDa protein 4-like 2.03095
FKTN fukutin 2.02675
PBK PDZ binding kinase 2.01625
TENM4 teneurin transmembrane protein 4 2.0073

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -5.8003
CYCS cytochrome c, somatic -5.08155
TSPAN4 tetraspanin 4 -4.83833
PGAM4 phosphoglycerate mutase family member 4 -4.77145
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.71775
ETFB electron-transfer-flavoprotein, beta polypeptide -4.44405
COPS7A COP9 signalosome subunit 7A -4.38895
ITGB1BP1 integrin beta 1 binding protein 1 -3.90172
TRAP1 TNF receptor-associated protein 1 -3.8776
EIF5 eukaryotic translation initiation factor 5 -3.60614
SLC2A14 solute carrier family 2 (facilitated glucose transporter), member 14 -3.47915
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -3.20235
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -3.08898
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -3.0176
CHRDL1 chordin-like 1 -2.9818
MT2A metallothionein 2A -2.9747
KIZ kizuna centrosomal protein -2.9125
ACAA1 acetyl-CoA acyltransferase 1 -2.89935
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha -2.8041
APOA2 apolipoprotein A-II -2.80297
ZC4H2 zinc finger, C4H2 domain containing -2.78765
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.75111
SMC1A structural maintenance of chromosomes 1A -2.7368
SNX7 sorting nexin 7 -2.68565
PRR13 proline rich 13 -2.6341
PRCP prolylcarboxypeptidase (angiotensinase C) -2.6049
REEP5 receptor accessory protein 5 -2.56085
IFNG interferon, gamma -2.4977
CD247 CD247 molecule -2.4798
LOC122539214 Zinc finger protein LOC122539214 -2.45325
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -2.44425
GOLT1A golgi transport 1A -2.4283
POU4F1 POU class 4 homeobox 1 -2.39975
CNMD chondromodulin -2.37035
AHSG alpha-2-HS-glycoprotein -2.36967
MTERF3 mitochondrial transcription termination factor 3 -2.3185
LAPTM4A lysosomal protein transmembrane 4 alpha -2.30085
IRF3 interferon regulatory factor 3 -2.29095
MSMO1 methylsterol monooxygenase 1 -2.27975
TRIM26 tripartite motif containing 26 -2.26185
GZMM granzyme M (lymphocyte met-ase 1) -2.259
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -2.24365
C1RL complement component 1, r subcomponent-like -2.2248
ADSS2 adenylosuccinate synthase 2 -2.22025
ZNF816 zinc finger protein 816 -2.2101
PLPP1 phospholipid phosphatase 1 -2.2005
ASGR2 asialoglycoprotein receptor 2 -2.18635
CST2 cystatin SA -2.14735
NDRG1 N-myc downstream regulated 1 -2.1442
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -2.14375
MAN1A1 mannosidase, alpha, class 1A, member 1 -2.12435
KDM5C lysine (K)-specific demethylase 5C -2.12065
HLF hepatic leukemia factor -2.1195
DUSP9 dual specificity phosphatase 9 -2.11025
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 -2.1064
LARP7 La ribonucleoprotein domain family, member 7 -2.10475
CST4 cystatin S -2.09715
GNPAT glyceronephosphate O-acyltransferase -2.097
SMIM10L1 small integral membrane protein 10 like 1 -2.0946
RBM34 RNA binding motif protein 34 -2.0933
PAGE1 P antigen family, member 1 (prostate associated) -2.08455
ANGPTL4 angiopoietin-like 4 -2.06675
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein -2.0654
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.06211
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.06023
GHITM growth hormone inducible transmembrane protein -2.03578
FBXO2 F-box protein 2 -2.0116
ZMAT4 zinc finger, matrin-type 4 -2.00675
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa -2.0028