CRCGN017_MCF10A.WT.HP_24H:F16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dibromoethane 98.95 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN017_MCF10A.WT.HP_24H:F16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 5.0628
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.0311
SSBP2 single-stranded DNA binding protein 2 4.18087
KCTD5 potassium channel tetramerization domain containing 5 3.4374
GRB10 growth factor receptor-bound protein 10 2.7753
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.64455
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.60085
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 2.5864
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.57197
REPIN1 replication initiator 1 2.5662
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.3791
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 2.2532
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 2.2317
SLC39A7 solute carrier family 39 (zinc transporter), member 7 2.153
GARRE1 granule associated Rac and RHOG effector 1 2.14795
DAZAP1 DAZ associated protein 1 2.1216
APH1A APH1A gamma secretase subunit 2.11275
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 2.05935

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -10.0
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -5.3412
TES testin LIM domain protein -5.2682
COG7 component of oligomeric golgi complex 7 -5.1015
TXNDC9 thioredoxin domain containing 9 -5.0755
HAT1 histone acetyltransferase 1 -4.8535
C2CD5 C2 calcium-dependent domain containing 5 -3.8348
PCNA proliferating cell nuclear antigen -3.81665
SGK1 serum/glucocorticoid regulated kinase 1 -3.60615
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.59068
KRT14 keratin 14, type I -3.40685
RESF1 retroelement silencing factor 1 -3.2346
LYPLA1 lysophospholipase I -3.18138
CRNKL1 crooked neck pre-mRNA splicing factor 1 -2.84795
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -2.84495
CAPRIN2 caprin family member 2 -2.69265
MED21 mediator complex subunit 21 -2.59735
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.45138
GLB1L galactosidase, beta 1-like -2.44905
MKKS McKusick-Kaufman syndrome -2.4464
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 -2.39808
STK38L serine/threonine kinase 38 like -2.38807
ERGIC2 ERGIC and golgi 2 -2.37275
S100A8 S100 calcium binding protein A8 -2.34555
NSFL1C NSFL1 (p97) cofactor (p47) -2.31663
KIF3B kinesin family member 3B -2.31565
PHKG1 phosphorylase kinase, gamma 1 (muscle) -2.30275
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 -2.29795
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -2.2964
INTS13 integrator complex subunit 13 -2.2769
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.24795
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.2316
PPP4C protein phosphatase 4, catalytic subunit -2.19505
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -2.19225
DYSF dysferlin -2.1902
NDOR1 NADPH dependent diflavin oxidoreductase 1 -2.1552
SUMO1 small ubiquitin-like modifier 1 -2.13108
TM7SF3 transmembrane 7 superfamily member 3 -2.1199
KRT33B keratin 33B, type I -2.11515
ZNF268 zinc finger protein 268 -2.11265
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.1086
ZCCHC10 zinc finger, CCHC domain containing 10 -2.08635
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -2.0636
PKP2 plakophilin 2 -2.06277
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein -2.0618
IGFBP7 insulin-like growth factor binding protein 7 -2.04288
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough -2.0337
ZNF133 zinc finger protein 133 -2.0241
ZNF222 zinc finger protein 222 -2.0075
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.0045
MSI1 musashi RNA-binding protein 1 -2.00365